Impaired HDL (high-density lipoprotein)-mediated macrophage cholesterol efflux in patients with abdominal aortic aneurysm-brief report

Objective-The ability of HDL (high-density lipoprotein) to promote macrophage cholesterol efflux is considered the main HDL cardioprotective function. Abdominal aortic aneurysm (AAA) is usually characterized by cholesterol accumulation and macrophage infiltration in the aortic wall. Here, we aim to...

Descripción completa

Detalles Bibliográficos
Autores: Martínez-López, Diego, Cedó, Lídia|||0000-0003-4354-3411, Metso, Jari, Burillo, Elena, Garcia León, Annabel|||0000-0003-3007-9306, Canyelles, Marina|||0000-0002-0278-5337, Lindholt, Jes S.|||0000-0001-9536-4488, Torres-Fonseca, Monica, Blanco-Colio, Luis Miguel|||0000-0002-1560-6609, Vázquez, Jesús|||0000-0003-1461-5092, Blanco Vaca, Francisco|||0000-0001-7380-5385, Jauhiainen, Matti|||0000-0002-3836-3785, Martín-Ventura, Jose Luis, Escolà-Gil, Joan Carles|||0000-0001-9021-2485
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:270426
Acceso en línea:https://ddd.uab.cat/record/270426
https://dx.doi.org/urn:doi:10.1161/ATVBAHA.118.311704
Access Level:acceso abierto
Palabra clave:Aneurysm
Apolipoprotein
Cells
Cholesterol
Macrophages
id ES_4fcdf4d38cc1b0ce693ea6935a1d19ed
oai_identifier_str oai:ddd.uab.cat:270426
network_acronym_str ES
network_name_str España
repository_id_str
spelling Impaired HDL (high-density lipoprotein)-mediated macrophage cholesterol efflux in patients with abdominal aortic aneurysm-brief reportMartínez-López, DiegoCedó, Lídia|||0000-0003-4354-3411Metso, JariBurillo, ElenaGarcia León, Annabel|||0000-0003-3007-9306Canyelles, Marina|||0000-0002-0278-5337Lindholt, Jes S.|||0000-0001-9536-4488Torres-Fonseca, MonicaBlanco-Colio, Luis Miguel|||0000-0002-1560-6609Vázquez, Jesús|||0000-0003-1461-5092Blanco Vaca, Francisco|||0000-0001-7380-5385Jauhiainen, Matti|||0000-0002-3836-3785Martín-Ventura, Jose LuisEscolà-Gil, Joan Carles|||0000-0001-9021-2485AneurysmApolipoproteinCellsCholesterolMacrophagesObjective-The ability of HDL (high-density lipoprotein) to promote macrophage cholesterol efflux is considered the main HDL cardioprotective function. Abdominal aortic aneurysm (AAA) is usually characterized by cholesterol accumulation and macrophage infiltration in the aortic wall. Here, we aim to evaluate the composition of circulating HDL particles and their potential for promoting macrophage cholesterol efflux in AAA subjects. Approach and Results-First, we randomly selected AAA and control subjects from Spain. The AAA patients in the Spanish cohort showed lower plasma apoA-I levels concomitantly associated with low levels of plasma HDL cholesterol and the amount of preβ-HDL particles. We determined macrophage cholesterol efflux to apoB-depleted plasma, which contains mature HDL, preβ-HDL particles and HDL regulatory proteins. ApoB-depleted plasma from AAA patients displayed an impaired ability to promote macrophage cholesterol efflux. Next, we replicated the experiments with AAA and control subjects derived from Danish cohort. Danish AAA patients also showed lower apoA-I levels and a defective HDL-mediated macrophage cholesterol efflux. Conclusions-AAA patients show impaired HDL-facilitated cholesterol removal from macrophages, which could be mechanistically linked to AAA. 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/270426https://dx.doi.org/urn:doi:10.1161/ATVBAHA.118.311704reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 16-00139Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2016-80843-Ropen accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2704262026-06-06T12:50:31Z
dc.title.none.fl_str_mv Impaired HDL (high-density lipoprotein)-mediated macrophage cholesterol efflux in patients with abdominal aortic aneurysm-brief report
title Impaired HDL (high-density lipoprotein)-mediated macrophage cholesterol efflux in patients with abdominal aortic aneurysm-brief report
spellingShingle Impaired HDL (high-density lipoprotein)-mediated macrophage cholesterol efflux in patients with abdominal aortic aneurysm-brief report
Martínez-López, Diego
Aneurysm
Apolipoprotein
Cells
Cholesterol
Macrophages
title_short Impaired HDL (high-density lipoprotein)-mediated macrophage cholesterol efflux in patients with abdominal aortic aneurysm-brief report
title_full Impaired HDL (high-density lipoprotein)-mediated macrophage cholesterol efflux in patients with abdominal aortic aneurysm-brief report
title_fullStr Impaired HDL (high-density lipoprotein)-mediated macrophage cholesterol efflux in patients with abdominal aortic aneurysm-brief report
title_full_unstemmed Impaired HDL (high-density lipoprotein)-mediated macrophage cholesterol efflux in patients with abdominal aortic aneurysm-brief report
title_sort Impaired HDL (high-density lipoprotein)-mediated macrophage cholesterol efflux in patients with abdominal aortic aneurysm-brief report
dc.creator.none.fl_str_mv Martínez-López, Diego
Cedó, Lídia|||0000-0003-4354-3411
Metso, Jari
Burillo, Elena
Garcia León, Annabel|||0000-0003-3007-9306
Canyelles, Marina|||0000-0002-0278-5337
Lindholt, Jes S.|||0000-0001-9536-4488
Torres-Fonseca, Monica
Blanco-Colio, Luis Miguel|||0000-0002-1560-6609
Vázquez, Jesús|||0000-0003-1461-5092
Blanco Vaca, Francisco|||0000-0001-7380-5385
Jauhiainen, Matti|||0000-0002-3836-3785
Martín-Ventura, Jose Luis
Escolà-Gil, Joan Carles|||0000-0001-9021-2485
author Martínez-López, Diego
author_facet Martínez-López, Diego
Cedó, Lídia|||0000-0003-4354-3411
Metso, Jari
Burillo, Elena
Garcia León, Annabel|||0000-0003-3007-9306
Canyelles, Marina|||0000-0002-0278-5337
Lindholt, Jes S.|||0000-0001-9536-4488
Torres-Fonseca, Monica
Blanco-Colio, Luis Miguel|||0000-0002-1560-6609
Vázquez, Jesús|||0000-0003-1461-5092
Blanco Vaca, Francisco|||0000-0001-7380-5385
Jauhiainen, Matti|||0000-0002-3836-3785
Martín-Ventura, Jose Luis
Escolà-Gil, Joan Carles|||0000-0001-9021-2485
author_role author
author2 Cedó, Lídia|||0000-0003-4354-3411
Metso, Jari
Burillo, Elena
Garcia León, Annabel|||0000-0003-3007-9306
Canyelles, Marina|||0000-0002-0278-5337
Lindholt, Jes S.|||0000-0001-9536-4488
Torres-Fonseca, Monica
Blanco-Colio, Luis Miguel|||0000-0002-1560-6609
Vázquez, Jesús|||0000-0003-1461-5092
Blanco Vaca, Francisco|||0000-0001-7380-5385
Jauhiainen, Matti|||0000-0002-3836-3785
Martín-Ventura, Jose Luis
Escolà-Gil, Joan Carles|||0000-0001-9021-2485
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Aneurysm
Apolipoprotein
Cells
Cholesterol
Macrophages
topic Aneurysm
Apolipoprotein
Cells
Cholesterol
Macrophages
description Objective-The ability of HDL (high-density lipoprotein) to promote macrophage cholesterol efflux is considered the main HDL cardioprotective function. Abdominal aortic aneurysm (AAA) is usually characterized by cholesterol accumulation and macrophage infiltration in the aortic wall. Here, we aim to evaluate the composition of circulating HDL particles and their potential for promoting macrophage cholesterol efflux in AAA subjects. Approach and Results-First, we randomly selected AAA and control subjects from Spain. The AAA patients in the Spanish cohort showed lower plasma apoA-I levels concomitantly associated with low levels of plasma HDL cholesterol and the amount of preβ-HDL particles. We determined macrophage cholesterol efflux to apoB-depleted plasma, which contains mature HDL, preβ-HDL particles and HDL regulatory proteins. ApoB-depleted plasma from AAA patients displayed an impaired ability to promote macrophage cholesterol efflux. Next, we replicated the experiments with AAA and control subjects derived from Danish cohort. Danish AAA patients also showed lower apoA-I levels and a defective HDL-mediated macrophage cholesterol efflux. Conclusions-AAA patients show impaired HDL-facilitated cholesterol removal from macrophages, which could be mechanistically linked to AAA.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/270426
https://dx.doi.org/urn:doi:10.1161/ATVBAHA.118.311704
url https://ddd.uab.cat/record/270426
https://dx.doi.org/urn:doi:10.1161/ATVBAHA.118.311704
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 16-00139
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2016-80843-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407842391293952
score 15,300719

Similares en LA Referencia