CpG methylation frequency of TET2, GRIA2, and CDKN2A genes in the North Atlantic fin whale varies with age and between populations.

Recovery rates for baleen whales that were decimated by exploitation vary between species and populations. Age determination is critical for the understanding of recovery trends and population structure, but determining age in free-ranging individuals remains challenging. Recent research has suggest...

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Autores: García-Vernet, Raquel, Martín, Berta, Peinado Morales, Miguel Á. (Miguel Ángel), Víkingsson, Gísli, Riutort León, Marta, Aguilar, Àlex
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/194219
Acceso en línea:https://hdl.handle.net/2445/194219
Access Level:acceso abierto
Palabra clave:Metilació
Gens
Balenes
Atlàntic, Oceà
Methylation
Genes
Whales
Atlantic Ocean
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spelling CpG methylation frequency of TET2, GRIA2, and CDKN2A genes in the North Atlantic fin whale varies with age and between populations.García-Vernet, RaquelMartín, BertaPeinado Morales, Miguel Á. (Miguel Ángel)Víkingsson, GísliRiutort León, MartaAguilar, ÀlexMetilacióGensBalenesAtlàntic, OceàMethylationGenesWhalesAtlantic OceanRecovery rates for baleen whales that were decimated by exploitation vary between species and populations. Age determination is critical for the understanding of recovery trends and population structure, but determining age in free-ranging individuals remains challenging. Recent research has suggested that the methylation level of some genes in skin samples may provide age determinations with accuracy. We selected nine CpG sites from three genes (TET2, CDKN2A, and GRIA2) and analyzed them in 40 skin samples from known-age individuals pertaining to two different populations of fin whales from the North Atlantic. We observed significant correlations with age in five CpG sites. We used three of these CpG sites to perform an epigenetic age estimation. Predictions had a standard deviation of 2.94, but regression between observed and predicted ages showed a clear underestimation for older fin whales. For further development, we suggest: (1) screening for new CpG sites associated with age that exhibit higher variability between individuals, and (2) including older animals whenever the sampling allows it. We also observed subtle, but significant differences between the two populations studied in one of the CpG sites (TET2_CpG + 21). We attributed these differences to genetic differences or to the dissimilar environments that affect both populations.Wiley2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/194219Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1111/mms.12808Marine Mammal Science, 2021, vol. 37, num. 4, p. 1230-1244https://doi.org/10.1111/mms.12808(c) Society for Marine Mammalogy, 2021info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1942192026-05-27T06:46:51Z
dc.title.none.fl_str_mv CpG methylation frequency of TET2, GRIA2, and CDKN2A genes in the North Atlantic fin whale varies with age and between populations.
title CpG methylation frequency of TET2, GRIA2, and CDKN2A genes in the North Atlantic fin whale varies with age and between populations.
spellingShingle CpG methylation frequency of TET2, GRIA2, and CDKN2A genes in the North Atlantic fin whale varies with age and between populations.
García-Vernet, Raquel
Metilació
Gens
Balenes
Atlàntic, Oceà
Methylation
Genes
Whales
Atlantic Ocean
title_short CpG methylation frequency of TET2, GRIA2, and CDKN2A genes in the North Atlantic fin whale varies with age and between populations.
title_full CpG methylation frequency of TET2, GRIA2, and CDKN2A genes in the North Atlantic fin whale varies with age and between populations.
title_fullStr CpG methylation frequency of TET2, GRIA2, and CDKN2A genes in the North Atlantic fin whale varies with age and between populations.
title_full_unstemmed CpG methylation frequency of TET2, GRIA2, and CDKN2A genes in the North Atlantic fin whale varies with age and between populations.
title_sort CpG methylation frequency of TET2, GRIA2, and CDKN2A genes in the North Atlantic fin whale varies with age and between populations.
dc.creator.none.fl_str_mv García-Vernet, Raquel
Martín, Berta
Peinado Morales, Miguel Á. (Miguel Ángel)
Víkingsson, Gísli
Riutort León, Marta
Aguilar, Àlex
author García-Vernet, Raquel
author_facet García-Vernet, Raquel
Martín, Berta
Peinado Morales, Miguel Á. (Miguel Ángel)
Víkingsson, Gísli
Riutort León, Marta
Aguilar, Àlex
author_role author
author2 Martín, Berta
Peinado Morales, Miguel Á. (Miguel Ángel)
Víkingsson, Gísli
Riutort León, Marta
Aguilar, Àlex
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Metilació
Gens
Balenes
Atlàntic, Oceà
Methylation
Genes
Whales
Atlantic Ocean
topic Metilació
Gens
Balenes
Atlàntic, Oceà
Methylation
Genes
Whales
Atlantic Ocean
description Recovery rates for baleen whales that were decimated by exploitation vary between species and populations. Age determination is critical for the understanding of recovery trends and population structure, but determining age in free-ranging individuals remains challenging. Recent research has suggested that the methylation level of some genes in skin samples may provide age determinations with accuracy. We selected nine CpG sites from three genes (TET2, CDKN2A, and GRIA2) and analyzed them in 40 skin samples from known-age individuals pertaining to two different populations of fin whales from the North Atlantic. We observed significant correlations with age in five CpG sites. We used three of these CpG sites to perform an epigenetic age estimation. Predictions had a standard deviation of 2.94, but regression between observed and predicted ages showed a clear underestimation for older fin whales. For further development, we suggest: (1) screening for new CpG sites associated with age that exhibit higher variability between individuals, and (2) including older animals whenever the sampling allows it. We also observed subtle, but significant differences between the two populations studied in one of the CpG sites (TET2_CpG + 21). We attributed these differences to genetic differences or to the dissimilar environments that affect both populations.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/194219
url https://hdl.handle.net/2445/194219
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1111/mms.12808
Marine Mammal Science, 2021, vol. 37, num. 4, p. 1230-1244
https://doi.org/10.1111/mms.12808
dc.rights.none.fl_str_mv (c) Society for Marine Mammalogy, 2021
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Society for Marine Mammalogy, 2021
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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