Frequency, intensity and localization of pain as risk factors for frailty in older adults

Background the association between pain characteristics and frailty risk is uncertain. Objective to investigate the separate impact of the frequency, intensity and location of pain on frailty risk and its possible mechanisms. Methods prospective cohort of 1505 individuals 63 years followed between 2...

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Autores: Rodriguez-Sanchez, I, Garcia-Esquinas, E, Mesas, AE, Martin-Moreno, JM, Rodriguez-Manas, L, Rodriguez-Artalejo, F
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p1807
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/1807
https://roderic.uv.es/handle/10550/70233
Access Level:acceso abierto
Palabra clave:pain
frailty
functional impairment
older people
prospective
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spelling Frequency, intensity and localization of pain as risk factors for frailty in older adultsRodriguez-Sanchez, IGarcia-Esquinas, EMesas, AEMartin-Moreno, JMRodriguez-Manas, LRodriguez-Artalejo, Fpainfrailtyfunctional impairmentolder peopleprospectiveBackground the association between pain characteristics and frailty risk is uncertain. Objective to investigate the separate impact of the frequency, intensity and location of pain on frailty risk and its possible mechanisms. Methods prospective cohort of 1505 individuals 63 years followed between 2012 and 2015 in Spain. In 2012, pain was classified into: lowest pain (Score 0), middle pain (Score 1-4) and highest pain (Score 5-6). Incident frailty was assessed in 2015 as having 3 Fried criteria or a Frailty Index (FI) 0.30. Results in multivariate analyses, the risk of frailty (measured with the Fried criteria or the FI) increased progressively with the frequency of pain, its intensity and the number of pain locations. Compared with those having the lowest pain score, the odds ratio (95% confidence interval) of Fried-based frailty was 1.24 (0.56-2.75) in the middle score and 2.39 (1.34-4.27; P-trend <0.01) in the highest score. Corresponding values for frailty as FI 0.30 were 1.39 (0.80-2.42) and 2.77 (1.81-4.24; P-trend <0.01). Odds ratios did not change after adjustment for alcohol intake, Mediterranean diet adherence or sedentary time, but were reduced with adjustment for pain-associated chronic diseases (cardiovascular disease, diabetes, chronic lung disease, osteomuscular disease and depression). A higher pain score was linked to higher risk of exhaustion and low physical activity (two out of five Fried criteria) and to a worse score in all FI domains. Conclusion frequency, intensity and location of pain were associated with higher risk of frailty. Study associations were partly explained by pain-associated morbidity.OXFORD UNIV PRESS2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/1807https://roderic.uv.es/handle/10550/70233AGE AND AGEINGISSN: 00020729ISSNe: 14682834reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p18072026-06-07T16:35:31Z
dc.title.none.fl_str_mv Frequency, intensity and localization of pain as risk factors for frailty in older adults
title Frequency, intensity and localization of pain as risk factors for frailty in older adults
spellingShingle Frequency, intensity and localization of pain as risk factors for frailty in older adults
Rodriguez-Sanchez, I
pain
frailty
functional impairment
older people
prospective
title_short Frequency, intensity and localization of pain as risk factors for frailty in older adults
title_full Frequency, intensity and localization of pain as risk factors for frailty in older adults
title_fullStr Frequency, intensity and localization of pain as risk factors for frailty in older adults
title_full_unstemmed Frequency, intensity and localization of pain as risk factors for frailty in older adults
title_sort Frequency, intensity and localization of pain as risk factors for frailty in older adults
dc.creator.none.fl_str_mv Rodriguez-Sanchez, I
Garcia-Esquinas, E
Mesas, AE
Martin-Moreno, JM
Rodriguez-Manas, L
Rodriguez-Artalejo, F
author Rodriguez-Sanchez, I
author_facet Rodriguez-Sanchez, I
Garcia-Esquinas, E
Mesas, AE
Martin-Moreno, JM
Rodriguez-Manas, L
Rodriguez-Artalejo, F
author_role author
author2 Garcia-Esquinas, E
Mesas, AE
Martin-Moreno, JM
Rodriguez-Manas, L
Rodriguez-Artalejo, F
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv pain
frailty
functional impairment
older people
prospective
topic pain
frailty
functional impairment
older people
prospective
description Background the association between pain characteristics and frailty risk is uncertain. Objective to investigate the separate impact of the frequency, intensity and location of pain on frailty risk and its possible mechanisms. Methods prospective cohort of 1505 individuals 63 years followed between 2012 and 2015 in Spain. In 2012, pain was classified into: lowest pain (Score 0), middle pain (Score 1-4) and highest pain (Score 5-6). Incident frailty was assessed in 2015 as having 3 Fried criteria or a Frailty Index (FI) 0.30. Results in multivariate analyses, the risk of frailty (measured with the Fried criteria or the FI) increased progressively with the frequency of pain, its intensity and the number of pain locations. Compared with those having the lowest pain score, the odds ratio (95% confidence interval) of Fried-based frailty was 1.24 (0.56-2.75) in the middle score and 2.39 (1.34-4.27; P-trend <0.01) in the highest score. Corresponding values for frailty as FI 0.30 were 1.39 (0.80-2.42) and 2.77 (1.81-4.24; P-trend <0.01). Odds ratios did not change after adjustment for alcohol intake, Mediterranean diet adherence or sedentary time, but were reduced with adjustment for pain-associated chronic diseases (cardiovascular disease, diabetes, chronic lung disease, osteomuscular disease and depression). A higher pain score was linked to higher risk of exhaustion and low physical activity (two out of five Fried criteria) and to a worse score in all FI domains. Conclusion frequency, intensity and location of pain were associated with higher risk of frailty. Study associations were partly explained by pain-associated morbidity.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/1807
https://roderic.uv.es/handle/10550/70233
url https://incliva.portalinvestigacion.com/publicaciones/1807
https://roderic.uv.es/handle/10550/70233
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS
publisher.none.fl_str_mv OXFORD UNIV PRESS
dc.source.none.fl_str_mv AGE AND AGEING
ISSN: 00020729
ISSNe: 14682834
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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