Shaping the transcriptional landscape through MAPK signaling

A change in the transcriptional landscape is an equilibrium-breaking event important for many biological processes. Mitogen-activated protein kinase (MAPK) signaling pathways are dedicated to sensing extracellular cues and are highly conserved across eukaryotes. Modulation of gene expression in resp...

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Detalles Bibliográficos
Autores: Nadal Ribelles, Mariona, 1984-, Solé Serra, Carme, Martínez Cebrián, Gerard, 1992-, Posas Garriga, Francesc, Nadal Clanchet, Eulàlia de
Tipo de recurso: capítulo de libro
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/70487
Acceso en línea:http://hdl.handle.net/10230/70487
http://dx.doi.org/10.5772/intechopen.80634
Access Level:acceso abierto
Palabra clave:MAP kinases
Signal transduction
Transcription
Gene expression
Chromatin
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spelling Shaping the transcriptional landscape through MAPK signalingNadal Ribelles, Mariona, 1984-Solé Serra, CarmeMartínez Cebrián, Gerard, 1992-Posas Garriga, FrancescNadal Clanchet, Eulàlia deMAP kinasesSignal transductionTranscriptionGene expressionChromatinA change in the transcriptional landscape is an equilibrium-breaking event important for many biological processes. Mitogen-activated protein kinase (MAPK) signaling pathways are dedicated to sensing extracellular cues and are highly conserved across eukaryotes. Modulation of gene expression in response to the extracellular environment is one of the main mechanisms by which MAPK regulates proteome homeostasis to orchestrate adaptive responses that determine cell fate. A massive body of knowledge generated from population and single-cell analyses has led to an understanding of how MAPK pathways operate. MAPKs have thus emerged as fundamental transcriptome regulators that function through a multi-layered control of gene expression, a process often deregulated in disease, which therefore provides an attractive target for therapeutic strategies. Here, we summarize the current understanding of the mechanisms underlying MAPK-mediated gene expression in organisms ranging from yeast to mammals.MNR is a recipient of a Maria de Maeztu Postdoctoral Fellowship (Doctores Banco de Santander-María de Maeztu at Universitat Pompeu Fabra). GMC is a recipient of an FPI Predoctoral Fellowship (Spanish Ministry of Economy and Industry and Competitiveness (MINECO). The FP and EdN’s laboratory is supported by grants from the Spanish Ministry of Economy and Competitiveness (BFU2015-64437-P to FP and BFU2017-85152-P and FEDER to EN), the Catalan Government (2017 SGR 799), the Fundación Botín, and the Banco Santander through its Santander Universities Global Division to FP and the Unidad de Excelencia Maria de Maeztu, MDM-2014-0370. FP is a recipient of an ICREA Acadèmia (Generalitat de Catalunya). We gratefully acknowledge funding from the Spanish Ministry of Economy, Industry, and Competitiveness (MINECO) through the Centers of Excellence Severo Ochoa award and from the CERCA Program of the Catalan Government.IntechOpen202520252019info:eu-repo/semantics/bookPartinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/70487http://dx.doi.org/10.5772/intechopen.80634http://hdl.handle.net/10230/70487reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésUchiumi F, editor. Gene expression and control. London, United Kingdom: Intechopen; 2019. p. 1-22info:eu-repo/grantAgreement/ES/1PE/BFU2015-64437-Pinfo:eu-repo/grantAgreement/ES/1PE/BFU2017-85152-P© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/3.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/704872026-05-29T05:05:01Z
dc.title.none.fl_str_mv Shaping the transcriptional landscape through MAPK signaling
title Shaping the transcriptional landscape through MAPK signaling
spellingShingle Shaping the transcriptional landscape through MAPK signaling
Nadal Ribelles, Mariona, 1984-
MAP kinases
Signal transduction
Transcription
Gene expression
Chromatin
title_short Shaping the transcriptional landscape through MAPK signaling
title_full Shaping the transcriptional landscape through MAPK signaling
title_fullStr Shaping the transcriptional landscape through MAPK signaling
title_full_unstemmed Shaping the transcriptional landscape through MAPK signaling
title_sort Shaping the transcriptional landscape through MAPK signaling
dc.creator.none.fl_str_mv Nadal Ribelles, Mariona, 1984-
Solé Serra, Carme
Martínez Cebrián, Gerard, 1992-
Posas Garriga, Francesc
Nadal Clanchet, Eulàlia de
author Nadal Ribelles, Mariona, 1984-
author_facet Nadal Ribelles, Mariona, 1984-
Solé Serra, Carme
Martínez Cebrián, Gerard, 1992-
Posas Garriga, Francesc
Nadal Clanchet, Eulàlia de
author_role author
author2 Solé Serra, Carme
Martínez Cebrián, Gerard, 1992-
Posas Garriga, Francesc
Nadal Clanchet, Eulàlia de
author2_role author
author
author
author
dc.subject.none.fl_str_mv MAP kinases
Signal transduction
Transcription
Gene expression
Chromatin
topic MAP kinases
Signal transduction
Transcription
Gene expression
Chromatin
description A change in the transcriptional landscape is an equilibrium-breaking event important for many biological processes. Mitogen-activated protein kinase (MAPK) signaling pathways are dedicated to sensing extracellular cues and are highly conserved across eukaryotes. Modulation of gene expression in response to the extracellular environment is one of the main mechanisms by which MAPK regulates proteome homeostasis to orchestrate adaptive responses that determine cell fate. A massive body of knowledge generated from population and single-cell analyses has led to an understanding of how MAPK pathways operate. MAPKs have thus emerged as fundamental transcriptome regulators that function through a multi-layered control of gene expression, a process often deregulated in disease, which therefore provides an attractive target for therapeutic strategies. Here, we summarize the current understanding of the mechanisms underlying MAPK-mediated gene expression in organisms ranging from yeast to mammals.
publishDate 2019
dc.date.none.fl_str_mv 2019
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/bookPart
info:eu-repo/semantics/publishedVersion
format bookPart
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/70487
http://dx.doi.org/10.5772/intechopen.80634
http://hdl.handle.net/10230/70487
url http://hdl.handle.net/10230/70487
http://dx.doi.org/10.5772/intechopen.80634
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Uchiumi F, editor. Gene expression and control. London, United Kingdom: Intechopen; 2019. p. 1-22
info:eu-repo/grantAgreement/ES/1PE/BFU2015-64437-P
info:eu-repo/grantAgreement/ES/1PE/BFU2017-85152-P
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/3.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IntechOpen
publisher.none.fl_str_mv IntechOpen
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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