Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New England

Background: Recent data provide support for the concept that potentially modifiable exposures are responsible for sporadic amyotrophic lateral sclerosis (ALS). Objective: To evaluate environmental and occupational exposures as risk factors for sporadic ALS. Methods: We performed a case control study...

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Detalhes bibliográficos
Autores: Andrew, Angeline S., Caller, Tracie A., Tandan, Rup, Duell, Eric J., Henegan, Patricia L., Field, Nicholas, Bradley, Walter G., Stommel, Elijah W.
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/125347
Acesso em linha:https://hdl.handle.net/2445/125347
Access Level:acceso abierto
Palavra-chave:Esclerosi lateral amiotròfica
Factors de risc en les malalties
Amyotrophic lateral sclerosis
Risk factors in diseases
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spelling Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New EnglandAndrew, Angeline S.Caller, Tracie A.Tandan, RupDuell, Eric J.Henegan, Patricia L.Field, NicholasBradley, Walter G.Stommel, Elijah W.Esclerosi lateral amiotròficaFactors de risc en les malaltiesAmyotrophic lateral sclerosisRisk factors in diseasesBackground: Recent data provide support for the concept that potentially modifiable exposures are responsible for sporadic amyotrophic lateral sclerosis (ALS). Objective: To evaluate environmental and occupational exposures as risk factors for sporadic ALS. Methods: We performed a case control study of ALS among residents of New England, USA. The analysis compared questionnaire responses from 295 patients with a confirmed ALS diagnosis to those of 225 controls without neurodegenerative illness. Results: Self-reported job-or hobby-related exposure to one or more chemicals, such as pesticides, solvents, or heavy metals, increased the risk of ALS (adjusted OR 2.51; 95% CI 1.64-3.89). Industries with a higher toxicant exposure potential (construction, manufacturing, mechanical, military, or painting) were associated with an elevated occupational risk (adjusted OR 3.95; 95% CI 2.04-8.30). We also identified increases in the risk of ALS associated with frequent participation in water sports, particularly waterskiing (adjusted OR 3.89; 95% C11.97-8.44). Occupation and waterskiing both retained independent statistical significance in a composite model containing age, gender, and smoking status. Conclusions: Our study contributes to a growing body of literature implicating occupational-and hobby-related toxicant exposures in ALS etiology. These epidemiologic study results also provide motivation for future evaluation of water-body-related risk factors. (C) 2017 S. Karger AG, BaselKarger2018201820172018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion13 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/125347Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1159/000453359Neurodegenerative Diseases, 2017, Vol. 17, Issue 2-3, P. 110-116https://doi.org/10.1159/000453359(c) Karger AG, 2017info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1253472026-05-29T05:05:01Z
dc.title.none.fl_str_mv Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New England
title Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New England
spellingShingle Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New England
Andrew, Angeline S.
Esclerosi lateral amiotròfica
Factors de risc en les malalties
Amyotrophic lateral sclerosis
Risk factors in diseases
title_short Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New England
title_full Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New England
title_fullStr Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New England
title_full_unstemmed Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New England
title_sort Environmental And Occupational Exposures And Amyotrophic Lateral Sclerosis In New England
dc.creator.none.fl_str_mv Andrew, Angeline S.
Caller, Tracie A.
Tandan, Rup
Duell, Eric J.
Henegan, Patricia L.
Field, Nicholas
Bradley, Walter G.
Stommel, Elijah W.
author Andrew, Angeline S.
author_facet Andrew, Angeline S.
Caller, Tracie A.
Tandan, Rup
Duell, Eric J.
Henegan, Patricia L.
Field, Nicholas
Bradley, Walter G.
Stommel, Elijah W.
author_role author
author2 Caller, Tracie A.
Tandan, Rup
Duell, Eric J.
Henegan, Patricia L.
Field, Nicholas
Bradley, Walter G.
Stommel, Elijah W.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Esclerosi lateral amiotròfica
Factors de risc en les malalties
Amyotrophic lateral sclerosis
Risk factors in diseases
topic Esclerosi lateral amiotròfica
Factors de risc en les malalties
Amyotrophic lateral sclerosis
Risk factors in diseases
description Background: Recent data provide support for the concept that potentially modifiable exposures are responsible for sporadic amyotrophic lateral sclerosis (ALS). Objective: To evaluate environmental and occupational exposures as risk factors for sporadic ALS. Methods: We performed a case control study of ALS among residents of New England, USA. The analysis compared questionnaire responses from 295 patients with a confirmed ALS diagnosis to those of 225 controls without neurodegenerative illness. Results: Self-reported job-or hobby-related exposure to one or more chemicals, such as pesticides, solvents, or heavy metals, increased the risk of ALS (adjusted OR 2.51; 95% CI 1.64-3.89). Industries with a higher toxicant exposure potential (construction, manufacturing, mechanical, military, or painting) were associated with an elevated occupational risk (adjusted OR 3.95; 95% CI 2.04-8.30). We also identified increases in the risk of ALS associated with frequent participation in water sports, particularly waterskiing (adjusted OR 3.89; 95% C11.97-8.44). Occupation and waterskiing both retained independent statistical significance in a composite model containing age, gender, and smoking status. Conclusions: Our study contributes to a growing body of literature implicating occupational-and hobby-related toxicant exposures in ALS etiology. These epidemiologic study results also provide motivation for future evaluation of water-body-related risk factors. (C) 2017 S. Karger AG, Basel
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125347
url https://hdl.handle.net/2445/125347
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1159/000453359
Neurodegenerative Diseases, 2017, Vol. 17, Issue 2-3, P. 110-116
https://doi.org/10.1159/000453359
dc.rights.none.fl_str_mv (c) Karger AG, 2017
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Karger AG, 2017
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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