The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice

Sanz Lamora, Héctor; Nicola Llorente, Mariano; Torres-Oteros, Daniel; Pérez-Martí, A.; Aghziel, Inass; Lozano Castellón, Julián; Vallverdú i Queralt, Anna; Canudas Puig, Sílvia; Marrero González, Pedro F.; Haro, D.; Relat Pardo, Joana

The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice

Scope: The rosehip (Rosa canina) is a perennial shrub with a reddish pseudofruit that has demonstrated antidiabetic, antiatherosclerotic, and antiobesogenic effects in rodent models but there is low information about the molecular mechanisms underlying these effects on the onset and progression of d...

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Autores:	Sanz Lamora, Héctor, Nicola Llorente, Mariano, Torres-Oteros, Daniel, Pérez-Martí, A., Aghziel, Inass, Lozano Castellón, Julián, Vallverdú i Queralt, Anna, Canudas Puig, Sílvia, Marrero González, Pedro F., Haro, D., Relat Pardo, Joana
Tipo de documento:	artigo
Estado:	Versão publicada
Data de publicação:	2024
País:	España
Recursos:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:dnet:recercat____::cc422c0d6dcc30ae7b519d1b304bcf5d
Acesso em linha:	https://hdl.handle.net/2445/229695
Access Level:	Acceso aberto
Palavra-chave:	Resistència a la insulina Obesitat Metabolisme dels lípids Insulin resistance Obesity Lipid metabolism

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spelling	The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed MiceSanz Lamora, HéctorNicola Llorente, MarianoTorres-Oteros, DanielPérez-Martí, A.Aghziel, InassLozano Castellón, JuliánVallverdú i Queralt, AnnaCanudas Puig, SílviaMarrero González, Pedro F.Haro, D.Relat Pardo, JoanaResistència a la insulinaObesitatMetabolisme dels lípidsInsulin resistanceObesityLipid metabolismScope: The rosehip (Rosa canina) is a perennial shrub with a reddish pseudofruit that has demonstrated antidiabetic, antiatherosclerotic, and antiobesogenic effects in rodent models but there is low information about the molecular mechanisms underlying these effects on the onset and progression of diet-induced obesity. Methods and results: Four-week-old C57BL/6J male mice are subjected to a high-fat diet (HFD)-supplemented or not with R. canina flesh for 18 weeks. The results indicated that the R. canina flesh exerts a preventive effect on HFD-induced obesity with a significant reduction in body-weight gain and an improvement of hyperglycemia and insulin resistance caused by a HFD. At the tissue level, subcutaneous white adipose tissue exhibits a higher number of smaller adipocytes, with decreased lipogenesis. On its side, the liver shows a significant decrease in lipid droplet content and in the expression of genes related to lipogenesis, fatty acid oxidation, and glucose metabolism. Finally, the data suggest that most of these effects agree with the presence of a putative Perosxisome proliferator-activated receptor gamma (PPAR ) antagonist in the R. canina flesh. Conclusions: R. canina flesh dietary supplementation slows down the steatotic effect of a HFD at least in part through the regulation of the transcriptional activity of PPAR .Wiley-VCH2026202620242026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/229695Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1002/mnfr.202300539Molecular Nutrition & Food Research, 2024, vol. 68, num.5, p. 2300539https://doi.org/10.1002/mnfr.202300539cc-by (c) Sanz Lamora, Héctor et al., 2024https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::cc422c0d6dcc30ae7b519d1b304bcf5d2026-05-29T05:05:01Z
dc.title.none.fl_str_mv	The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice
title	The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice
spellingShingle	The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice Sanz Lamora, Héctor Resistència a la insulina Obesitat Metabolisme dels lípids Insulin resistance Obesity Lipid metabolism
title_short	The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice
title_full	The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice
title_fullStr	The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice
title_full_unstemmed	The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice
title_sort	The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice
dc.creator.none.fl_str_mv	Sanz Lamora, Héctor Nicola Llorente, Mariano Torres-Oteros, Daniel Pérez-Martí, A. Aghziel, Inass Lozano Castellón, Julián Vallverdú i Queralt, Anna Canudas Puig, Sílvia Marrero González, Pedro F. Haro, D. Relat Pardo, Joana
author	Sanz Lamora, Héctor
author_facet	Sanz Lamora, Héctor Nicola Llorente, Mariano Torres-Oteros, Daniel Pérez-Martí, A. Aghziel, Inass Lozano Castellón, Julián Vallverdú i Queralt, Anna Canudas Puig, Sílvia Marrero González, Pedro F. Haro, D. Relat Pardo, Joana
author_role	author
author2	Nicola Llorente, Mariano Torres-Oteros, Daniel Pérez-Martí, A. Aghziel, Inass Lozano Castellón, Julián Vallverdú i Queralt, Anna Canudas Puig, Sílvia Marrero González, Pedro F. Haro, D. Relat Pardo, Joana
author2_role	author author author author author author author author author author
dc.subject.none.fl_str_mv	Resistència a la insulina Obesitat Metabolisme dels lípids Insulin resistance Obesity Lipid metabolism
topic	Resistència a la insulina Obesitat Metabolisme dels lípids Insulin resistance Obesity Lipid metabolism
description	Scope: The rosehip (Rosa canina) is a perennial shrub with a reddish pseudofruit that has demonstrated antidiabetic, antiatherosclerotic, and antiobesogenic effects in rodent models but there is low information about the molecular mechanisms underlying these effects on the onset and progression of diet-induced obesity. Methods and results: Four-week-old C57BL/6J male mice are subjected to a high-fat diet (HFD)-supplemented or not with R. canina flesh for 18 weeks. The results indicated that the R. canina flesh exerts a preventive effect on HFD-induced obesity with a significant reduction in body-weight gain and an improvement of hyperglycemia and insulin resistance caused by a HFD. At the tissue level, subcutaneous white adipose tissue exhibits a higher number of smaller adipocytes, with decreased lipogenesis. On its side, the liver shows a significant decrease in lipid droplet content and in the expression of genes related to lipogenesis, fatty acid oxidation, and glucose metabolism. Finally, the data suggest that most of these effects agree with the presence of a putative Perosxisome proliferator-activated receptor gamma (PPAR ) antagonist in the R. canina flesh. Conclusions: R. canina flesh dietary supplementation slows down the steatotic effect of a HFD at least in part through the regulation of the transcriptional activity of PPAR .
publishDate	2024
dc.date.none.fl_str_mv	2024 2026 2026 2026
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/229695
url	https://hdl.handle.net/2445/229695
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1002/mnfr.202300539 Molecular Nutrition & Food Research, 2024, vol. 68, num.5, p. 2300539 https://doi.org/10.1002/mnfr.202300539
dc.rights.none.fl_str_mv	cc-by (c) Sanz Lamora, Héctor et al., 2024 https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Sanz Lamora, Héctor et al., 2024 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	11 p. application/pdf
dc.publisher.none.fl_str_mv	Wiley-VCH
publisher.none.fl_str_mv	Wiley-VCH
dc.source.none.fl_str_mv	Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.812429

The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice

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