The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019

Background: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform can...

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Autores: GBD 2019 Cancer Risk Factors Collaborators, Padron-Monedero, Alicia
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/15942
Acceso en línea:http://hdl.handle.net/20.500.12105/15942
Access Level:acceso abierto
Palabra clave:Global Burden of Disease
Neoplasms
Female
Global Health
Humans
Male
Quality-Adjusted Life Years
Risk Assessment
Risk Factors
Smoking
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
title The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
spellingShingle The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
GBD 2019 Cancer Risk Factors Collaborators
Global Burden of Disease
Neoplasms
Female
Global Health
Humans
Male
Quality-Adjusted Life Years
Risk Assessment
Risk Factors
Smoking
title_short The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
title_full The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
title_fullStr The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
title_full_unstemmed The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
title_sort The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019
dc.creator.none.fl_str_mv GBD 2019 Cancer Risk Factors Collaborators
Padron-Monedero, Alicia
author GBD 2019 Cancer Risk Factors Collaborators
author_facet GBD 2019 Cancer Risk Factors Collaborators
Padron-Monedero, Alicia
author_role author
author2 Padron-Monedero, Alicia
author2_role author
dc.contributor.none.fl_str_mv Bill & Melinda Gates Foundation
Ministry of Higher Education (Malasia)
Unión Europea. Comisión Europea. European Research Council (ERC)
Unión Europea. Comisión Europea. H2020
Fundação para a Ciência e Tecnologia (Portugal)
Federal Ministry of Education & Research (Alemania)
Alexander von Humboldt Foundation
Novo Nordisk Foundation
National Institute for Health Research (Reino Unido)
National Health and Medical Research Council (Australia)
Ministry of Education, Science and Technological Development (Serbia)
Sigrid Jusélius Foundation
National Natural Science Foundation of China
Wellcome Trust
National Council for Scientific and Technological Development (Brasil)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)
National Institutes of Health (Estados Unidos)
University of Oxford (Reino Unido)
Ministero della Salute (Italia)
King College London
DBT India Alliance (India)
Kuwait University (Kuwait)
Lega Italiana per la Lotta ai Tumori
Health Effects Institute (Estados Unidos)
African-German Network of Excellence in Science (AGNES)
Romanian National Authority for Scientific Research and Innovation
Romanian Ministry of Research Innovation and Digitalization
Finnish Cancer Foundation
Datta Meghe Institute of Medical Sciences (India)
Xiamen University Malaysia (Malasia)
Manipal Academy of Higher Education (India)
Panjab University (India)
Sistema Nacional de Investigación (Panamá)
Secretaría Nacional de Ciencia, Tecnología e Innovación (Panamá)
Ministry of Science and Technology (Taiwan)
Lung Foundation Australia
UNSW Sydney (Australia)
ICMR - National Institute of Epidemiology (India)
University of Tasmania (Australia)
Institute for Advanced Studies in Basic Sciences (Irán)
Ain Shams University (Egipto)
International Center of Medical Sciences Research (Islamabad)
National Institute of Genetic Engineering and Biotechnology (Irán)
Marga und Walter Boll - Stiftung
IRCCS Materno Infantile Burlo Garofolo (Italia)
dc.subject.none.fl_str_mv Global Burden of Disease
Neoplasms
Female
Global Health
Humans
Male
Quality-Adjusted Life Years
Risk Assessment
Risk Factors
Smoking
topic Global Burden of Disease
Neoplasms
Female
Global Health
Humans
Male
Quality-Adjusted Life Years
Risk Assessment
Risk Factors
Smoking
description Background: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01-4·94) deaths and 105 million (95·0-116) DALYs for both sexes combined, representing 44·4% (41·3-48·4) of all cancer deaths and 42·0% (39·1-45·6) of all DALYs. There were 2·88 million (2·60-3·18) risk-attributable cancer deaths in males (50·6% [47·8-54·1] of all male cancer deaths) and 1·58 million (1·36-1·84) risk-attributable cancer deaths in females (36·3% [32·5-41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6-28·4) and DALYs by 16·8% (8·8-25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9-42·8] and 33·3% [25·8-42·0]). Interpretation: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-08-20
2022
2022-08-20
2023
2023-05-03
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/15942
url http://hdl.handle.net/20.500.12105/15942
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 848325
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407835540946944
spelling The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019GBD 2019 Cancer Risk Factors CollaboratorsPadron-Monedero, AliciaGlobal Burden of DiseaseNeoplasmsFemaleGlobal HealthHumansMaleQuality-Adjusted Life YearsRisk AssessmentRisk FactorsSmokingBackground: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01-4·94) deaths and 105 million (95·0-116) DALYs for both sexes combined, representing 44·4% (41·3-48·4) of all cancer deaths and 42·0% (39·1-45·6) of all DALYs. There were 2·88 million (2·60-3·18) risk-attributable cancer deaths in males (50·6% [47·8-54·1] of all male cancer deaths) and 1·58 million (1·36-1·84) risk-attributable cancer deaths in females (36·3% [32·5-41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6-28·4) and DALYs by 16·8% (8·8-25·0), with the greatest percentage increase in metabolic risks (34·7% [27·9-42·8] and 33·3% [25·8-42·0]). Interpretation: The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden.ElsevierBill & Melinda Gates FoundationMinistry of Higher Education (Malasia)Unión Europea. Comisión Europea. European Research Council (ERC)Unión Europea. Comisión Europea. H2020Fundação para a Ciência e Tecnologia (Portugal)Federal Ministry of Education & Research (Alemania)Alexander von Humboldt FoundationNovo Nordisk FoundationNational Institute for Health Research (Reino Unido)National Health and Medical Research Council (Australia)Ministry of Education, Science and Technological Development (Serbia)Sigrid Jusélius FoundationNational Natural Science Foundation of ChinaWellcome TrustNational Council for Scientific and Technological Development (Brasil)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil)National Institutes of Health (Estados Unidos)University of Oxford (Reino Unido)Ministero della Salute (Italia)King College LondonDBT India Alliance (India)Kuwait University (Kuwait)Lega Italiana per la Lotta ai TumoriHealth Effects Institute (Estados Unidos)African-German Network of Excellence in Science (AGNES)Romanian National Authority for Scientific Research and InnovationRomanian Ministry of Research Innovation and DigitalizationFinnish Cancer FoundationDatta Meghe Institute of Medical Sciences (India)Xiamen University Malaysia (Malasia)Manipal Academy of Higher Education (India)Panjab University (India)Sistema Nacional de Investigación (Panamá)Secretaría Nacional de Ciencia, Tecnología e Innovación (Panamá)Ministry of Science and Technology (Taiwan)Lung Foundation AustraliaUNSW Sydney (Australia)ICMR - National Institute of Epidemiology (India)University of Tasmania (Australia)Institute for Advanced Studies in Basic Sciences (Irán)Ain Shams University (Egipto)International Center of Medical Sciences Research (Islamabad)National Institute of Genetic Engineering and Biotechnology (Irán)Marga und Walter Boll - StiftungIRCCS Materno Infantile Burlo Garofolo (Italia)20232023-05-0320222022-08-2020222022-08-20research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/15942reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 848325open accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/159422026-06-12T12:43:37Z
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