Effect of somatostatin on the mass accumulation of inositol-1,4,5- trisphosphate in rat hypothalamus, striatum, frontoparietal cortex and hippocampus
Somatostatin-14 (SS) significantly increased inositol-1,4,5-triphosphate (IP3) accumulation in rat hypothalamic, striatal, frontoparietal cortical and hippocampal slices. However, this stimulation of IP3accumulation by SS was highest in the frontoparietal cortex and hippocampus. The effect was alrea...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 1995 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/2282 |
| Acceso en línea: | http://hdl.handle.net/10017/2282 https://dx.doi.org/10.1016/0304-3940(95)11896-5 |
| Access Level: | acceso abierto |
| Palabra clave: | Somatostatin Inositol-1-4-5-trisphosphate Brain Rat Bioquímica Ciencia Biochemistry Science |
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Effect of somatostatin on the mass accumulation of inositol-1,4,5- trisphosphate in rat hypothalamus, striatum, frontoparietal cortex and hippocampusMuñoz Acedo, GemaIzquierdo Claros, Rosa MaríaSánchez Alonso, Jesús AdolfoHoyo Medinilla, María Nancy delPérez Albarsanz, Miguel AArilla Ferreiro, EduardoSomatostatinInositol-1-4-5-trisphosphateBrainRatBioquímicaCienciaBiochemistryScienceSomatostatin-14 (SS) significantly increased inositol-1,4,5-triphosphate (IP3) accumulation in rat hypothalamic, striatal, frontoparietal cortical and hippocampal slices. However, this stimulation of IP3accumulation by SS was highest in the frontoparietal cortex and hippocampus. The effect was already significant with 0.01 μM in the frontoparietal cortex (P < 0.05) and hippocampus (P < 0.05) and the maximal accumulation was evident with 0.1 μM SS, in all areas studied. A concentration of 1 μM SS, lacked this effect in hypothalamus and striatum. SS rapidly increased IP3 accumulation in all brain areas studied. This effect was maximal at 15 s of incubation and decreased subsequently. At 60 s incubation, levels were still elevated in frontoparietal cortex and hippocampus but had returned to basal values in hypothalamus and striatum. Somatostatin-28 (SS-28) and the SS analogues, D-Trp8-D-Cys14 and SMS 201–995, also significantly stimulated IP3 accumulation although the effect of SMS 201–995 was greater than that of SS in the striatum in comparison with controls (P < 0.001 and P < 0.01, respectively). These results suggest that SS action at the hypothalamus, striatum, frontoparietal cortex and hippocampus is mediated at least in part by the accumulation of IP3, which may initiate intracellular processes responsible for some biological SS effects.Ministerio de Educación y CienciaElsevier19951995-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/2282https://dx.doi.org/10.1016/0304-3940(95)11896-5reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengMinisterio de Educación y Ciencia Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/22822026-06-18T11:13:07Z |
| dc.title.none.fl_str_mv |
Effect of somatostatin on the mass accumulation of inositol-1,4,5- trisphosphate in rat hypothalamus, striatum, frontoparietal cortex and hippocampus |
| title |
Effect of somatostatin on the mass accumulation of inositol-1,4,5- trisphosphate in rat hypothalamus, striatum, frontoparietal cortex and hippocampus |
| spellingShingle |
Effect of somatostatin on the mass accumulation of inositol-1,4,5- trisphosphate in rat hypothalamus, striatum, frontoparietal cortex and hippocampus Muñoz Acedo, Gema Somatostatin Inositol-1-4-5-trisphosphate Brain Rat Bioquímica Ciencia Biochemistry Science |
| title_short |
Effect of somatostatin on the mass accumulation of inositol-1,4,5- trisphosphate in rat hypothalamus, striatum, frontoparietal cortex and hippocampus |
| title_full |
Effect of somatostatin on the mass accumulation of inositol-1,4,5- trisphosphate in rat hypothalamus, striatum, frontoparietal cortex and hippocampus |
| title_fullStr |
Effect of somatostatin on the mass accumulation of inositol-1,4,5- trisphosphate in rat hypothalamus, striatum, frontoparietal cortex and hippocampus |
| title_full_unstemmed |
Effect of somatostatin on the mass accumulation of inositol-1,4,5- trisphosphate in rat hypothalamus, striatum, frontoparietal cortex and hippocampus |
| title_sort |
Effect of somatostatin on the mass accumulation of inositol-1,4,5- trisphosphate in rat hypothalamus, striatum, frontoparietal cortex and hippocampus |
| dc.creator.none.fl_str_mv |
Muñoz Acedo, Gema Izquierdo Claros, Rosa María Sánchez Alonso, Jesús Adolfo Hoyo Medinilla, María Nancy del Pérez Albarsanz, Miguel A Arilla Ferreiro, Eduardo |
| author |
Muñoz Acedo, Gema |
| author_facet |
Muñoz Acedo, Gema Izquierdo Claros, Rosa María Sánchez Alonso, Jesús Adolfo Hoyo Medinilla, María Nancy del Pérez Albarsanz, Miguel A Arilla Ferreiro, Eduardo |
| author_role |
author |
| author2 |
Izquierdo Claros, Rosa María Sánchez Alonso, Jesús Adolfo Hoyo Medinilla, María Nancy del Pérez Albarsanz, Miguel A Arilla Ferreiro, Eduardo |
| author2_role |
author author author author author |
| dc.subject.none.fl_str_mv |
Somatostatin Inositol-1-4-5-trisphosphate Brain Rat Bioquímica Ciencia Biochemistry Science |
| topic |
Somatostatin Inositol-1-4-5-trisphosphate Brain Rat Bioquímica Ciencia Biochemistry Science |
| description |
Somatostatin-14 (SS) significantly increased inositol-1,4,5-triphosphate (IP3) accumulation in rat hypothalamic, striatal, frontoparietal cortical and hippocampal slices. However, this stimulation of IP3accumulation by SS was highest in the frontoparietal cortex and hippocampus. The effect was already significant with 0.01 μM in the frontoparietal cortex (P < 0.05) and hippocampus (P < 0.05) and the maximal accumulation was evident with 0.1 μM SS, in all areas studied. A concentration of 1 μM SS, lacked this effect in hypothalamus and striatum. SS rapidly increased IP3 accumulation in all brain areas studied. This effect was maximal at 15 s of incubation and decreased subsequently. At 60 s incubation, levels were still elevated in frontoparietal cortex and hippocampus but had returned to basal values in hypothalamus and striatum. Somatostatin-28 (SS-28) and the SS analogues, D-Trp8-D-Cys14 and SMS 201–995, also significantly stimulated IP3 accumulation although the effect of SMS 201–995 was greater than that of SS in the striatum in comparison with controls (P < 0.001 and P < 0.01, respectively). These results suggest that SS action at the hypothalamus, striatum, frontoparietal cortex and hippocampus is mediated at least in part by the accumulation of IP3, which may initiate intracellular processes responsible for some biological SS effects. |
| publishDate |
1995 |
| dc.date.none.fl_str_mv |
1995 1995-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 NA http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10017/2282 https://dx.doi.org/10.1016/0304-3940(95)11896-5 |
| url |
http://hdl.handle.net/10017/2282 https://dx.doi.org/10.1016/0304-3940(95)11896-5 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Educación y Ciencia Not available Not available |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:e_Buah Biblioteca Digital Universidad de Alcalá instname:Universidad de Alcalá (UAH) |
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Universidad de Alcalá (UAH) |
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e_Buah Biblioteca Digital Universidad de Alcalá |
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e_Buah Biblioteca Digital Universidad de Alcalá |
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