Synthesis of Novel Amphiphilic Fluorinated Polymers for the Dispersion of Hydrophobic Gold Nanoparticles, Quantum Dots, or Highly Fluorinated Molecules in Water

The transfer of inorganic nanoparticles (NPs) into water is usually considered a challenge, as NPs are preferably synthesized in organic solvents and commonly bear hydrophobic ligands. Consequently, various methods have been reported to achieve their transfer to aqueous media. Among these, a polymer...

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Autores: Llorente, Galder, Arango, Juan Manuel, Soto, Noelia, Kyzyma, Olena, Yánez Crespo, Andrés Alejandro, Blanchet, Clement, Garcia-Etxarri, Aitzol, Cárdenas, Marité, Carril, Mónica
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/413109
Acceso en línea:http://hdl.handle.net/10261/413109
https://api.elsevier.com/content/abstract/scopus_id/105025122028
Access Level:acceso abierto
Palabra clave:Fluorinated polymers
19F MRI contrast agents
NP polymer coating
QDs fractals
SAXS
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repository_id_str
dc.title.none.fl_str_mv Synthesis of Novel Amphiphilic Fluorinated Polymers for the Dispersion of Hydrophobic Gold Nanoparticles, Quantum Dots, or Highly Fluorinated Molecules in Water
title Synthesis of Novel Amphiphilic Fluorinated Polymers for the Dispersion of Hydrophobic Gold Nanoparticles, Quantum Dots, or Highly Fluorinated Molecules in Water
spellingShingle Synthesis of Novel Amphiphilic Fluorinated Polymers for the Dispersion of Hydrophobic Gold Nanoparticles, Quantum Dots, or Highly Fluorinated Molecules in Water
Llorente, Galder
Fluorinated polymers
19F MRI contrast agents
NP polymer coating
QDs fractals
SAXS
title_short Synthesis of Novel Amphiphilic Fluorinated Polymers for the Dispersion of Hydrophobic Gold Nanoparticles, Quantum Dots, or Highly Fluorinated Molecules in Water
title_full Synthesis of Novel Amphiphilic Fluorinated Polymers for the Dispersion of Hydrophobic Gold Nanoparticles, Quantum Dots, or Highly Fluorinated Molecules in Water
title_fullStr Synthesis of Novel Amphiphilic Fluorinated Polymers for the Dispersion of Hydrophobic Gold Nanoparticles, Quantum Dots, or Highly Fluorinated Molecules in Water
title_full_unstemmed Synthesis of Novel Amphiphilic Fluorinated Polymers for the Dispersion of Hydrophobic Gold Nanoparticles, Quantum Dots, or Highly Fluorinated Molecules in Water
title_sort Synthesis of Novel Amphiphilic Fluorinated Polymers for the Dispersion of Hydrophobic Gold Nanoparticles, Quantum Dots, or Highly Fluorinated Molecules in Water
dc.creator.none.fl_str_mv Llorente, Galder
Arango, Juan Manuel
Soto, Noelia
Kyzyma, Olena
Yánez Crespo, Andrés Alejandro
Blanchet, Clement
Garcia-Etxarri, Aitzol
Cárdenas, Marité
Carril, Mónica
author Llorente, Galder
author_facet Llorente, Galder
Arango, Juan Manuel
Soto, Noelia
Kyzyma, Olena
Yánez Crespo, Andrés Alejandro
Blanchet, Clement
Garcia-Etxarri, Aitzol
Cárdenas, Marité
Carril, Mónica
author_role author
author2 Arango, Juan Manuel
Soto, Noelia
Kyzyma, Olena
Yánez Crespo, Andrés Alejandro
Blanchet, Clement
Garcia-Etxarri, Aitzol
Cárdenas, Marité
Carril, Mónica
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Eusko Jaurlaritza
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
Fundación Biofísica Bizkaia
Swedish Research Council
Llorente, Galder [0000-0002-3746-4904]
Garcia-Etxarri, Aitzol [0000-0002-5867-2390]
Cárdenas, Marité [0000-0003-0392-3540]
Carril, Mónica [0000-0002-1232-8658]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Fluorinated polymers
19F MRI contrast agents
NP polymer coating
QDs fractals
SAXS
topic Fluorinated polymers
19F MRI contrast agents
NP polymer coating
QDs fractals
SAXS
description The transfer of inorganic nanoparticles (NPs) into water is usually considered a challenge, as NPs are preferably synthesized in organic solvents and commonly bear hydrophobic ligands. Consequently, various methods have been reported to achieve their transfer to aqueous media. Among these, a polymer coating using amphiphilic polymers represents a particularly useful approach. These polymers can interact with the NP surface via their hydrophobic moieties, while their hydrophilic side remains exposed to the aqueous media, thus enabling dispersion in water. In this paper, we present the facile synthesis of several fluorinated, hydrosoluble amphiphilic polymers, and we study the coating of different types of metallic NPs, such as gold nanoparticles and quantum dots (QDs). Gold NPs were transferred via a phase transfer protocol, but for more sensitive QDs, we used the film hydration method. For QDs, the high hydrophobicity of fluorinated moieties on the polymer was particularly advantageous in repelling water and preserving the optical properties of QDs. Fractal arrangements in aqueous solution for polymer-coated QDs were analyzed by small-angle X-ray scattering (SAXS) but also observed by TEM. Additionally, we employed these fluorinated polymers to transfer two highly hydrophobic and fluorinated molecules (PERFECTA and PFCE), commonly used as contrast agents in 19F magnetic resonance imaging (19F MRI), into aqueous media. We evaluated their transverse and longitudinal relaxation times to assess their suitability for use as contrast agents for 19F MRI.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/413109
https://api.elsevier.com/content/abstract/scopus_id/105025122028
url http://hdl.handle.net/10261/413109
https://api.elsevier.com/content/abstract/scopus_id/105025122028
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142008NB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-137440NB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1021/acsnanoscienceau.5c00069
https://doi.org/10.1021/acsnanoscienceau.5c00069
Sí
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv ACS Publications
publisher.none.fl_str_mv ACS Publications
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Synthesis of Novel Amphiphilic Fluorinated Polymers for the Dispersion of Hydrophobic Gold Nanoparticles, Quantum Dots, or Highly Fluorinated Molecules in WaterLlorente, GalderArango, Juan ManuelSoto, NoeliaKyzyma, OlenaYánez Crespo, Andrés AlejandroBlanchet, ClementGarcia-Etxarri, AitzolCárdenas, MaritéCarril, MónicaFluorinated polymers19F MRI contrast agentsNP polymer coatingQDs fractalsSAXSThe transfer of inorganic nanoparticles (NPs) into water is usually considered a challenge, as NPs are preferably synthesized in organic solvents and commonly bear hydrophobic ligands. Consequently, various methods have been reported to achieve their transfer to aqueous media. Among these, a polymer coating using amphiphilic polymers represents a particularly useful approach. These polymers can interact with the NP surface via their hydrophobic moieties, while their hydrophilic side remains exposed to the aqueous media, thus enabling dispersion in water. In this paper, we present the facile synthesis of several fluorinated, hydrosoluble amphiphilic polymers, and we study the coating of different types of metallic NPs, such as gold nanoparticles and quantum dots (QDs). Gold NPs were transferred via a phase transfer protocol, but for more sensitive QDs, we used the film hydration method. For QDs, the high hydrophobicity of fluorinated moieties on the polymer was particularly advantageous in repelling water and preserving the optical properties of QDs. Fractal arrangements in aqueous solution for polymer-coated QDs were analyzed by small-angle X-ray scattering (SAXS) but also observed by TEM. Additionally, we employed these fluorinated polymers to transfer two highly hydrophobic and fluorinated molecules (PERFECTA and PFCE), commonly used as contrast agents in 19F magnetic resonance imaging (19F MRI), into aqueous media. We evaluated their transverse and longitudinal relaxation times to assess their suitability for use as contrast agents for 19F MRI.A.G.-E. and G.L. acknowledge funding from the IKUR Strategy under the collaboration agreement between Ikerbasque Foundation and DIPC on behalf of the Department of Education of the Basque Government, Programa de ayudas de apoyo a los agentes de la Red Vasca de Ciencia, Tecnología e Innovación acreditados en la categoría de Centros de Investigación Básica y de Excelencia (Programa BERC) from the Departamento de Universidades e Investigación del Gobierno Vasco, as well as the Basque Government Elkartek program (KK-2023/00016) and the Spanish Ministerio de Ciencia e Innovación (PID2022-142008NB-I00). M.Carril, M.Cárdenas, and N.S. acknowledge the financial support received from the IKUR Strategy under the collaboration agreement between Ikerbasque Foundation and Fundación Biofísica Bizkaia on behalf of the Department of Education of the Basque Government. This work was supported in part by the Fundación Biofísica Bizkaia and the Basque Excellence Research Centre (BERC) program of the Basque Government. M.Carril and J.M.A. acknowledge funding from the Basque Government (Grupos Consolidados IT1449-22). M.Cárdenas and O.K. acknowledge economic support from the Vetenskapsrådet─Swedish Research Council (grant number 202105963), the Spanish Ministry of Science and Innovation (PID2022-137440NB-I00 funded by MICIU/AEI/10.13039/501100011033 and by FEDER, UE).Peer reviewedACS PublicationsEusko JaurlaritzaMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)Fundación Biofísica BizkaiaSwedish Research CouncilLlorente, Galder [0000-0002-3746-4904]Garcia-Etxarri, Aitzol [0000-0002-5867-2390]Cárdenas, Marité [0000-0003-0392-3540]Carril, Mónica [0000-0002-1232-8658]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/413109https://api.elsevier.com/content/abstract/scopus_id/105025122028reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-142008NB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-137440NB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1021/acsnanoscienceau.5c00069https://doi.org/10.1021/acsnanoscienceau.5c00069Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4131092026-05-22T06:33:51Z
score 15.198674

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