Anti-smoking legislation and its effects on urinary cotinine and cadmium levels

Anti-smoking legislation has been associated with an improvement in health indicators. Since the cadmium (Cd) body burden in the general population is markedly increased by smoke exposure, we analyzed the impact of the more restrictive legislation that came into force in Spain in 2011 by measuring C...

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Detalhes bibliográficos
Autores: Sánchez-Rodríguez, Jinny E, Bartolome, Monica, Cañas Portilla, Ana Isabel, Huetos, Olga, Navarro Rivas, Carmen, Rodríguez, A Carolina, Arribas, Misericordia, Esteban-Lopez, Marta, Lopez-Herranz, Ana, Castaño, Argelia
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/10096
Acesso em linha:http://hdl.handle.net/20.500.12105/10096
Access Level:acceso abierto
Palavra-chave:Cadmium
Cotinine
Female
Humans
Male
Smoking
Spain
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spelling Anti-smoking legislation and its effects on urinary cotinine and cadmium levelsSánchez-Rodríguez, Jinny EBartolome, MonicaCañas Portilla, Ana IsabelHuetos, OlgaNavarro Rivas, CarmenRodríguez, A CarolinaArribas, MisericordiaEsteban-Lopez, MartaLopez-Herranz, AnaCastaño, ArgeliaCadmiumCotinineFemaleHumansMaleSmokingSpainAnti-smoking legislation has been associated with an improvement in health indicators. Since the cadmium (Cd) body burden in the general population is markedly increased by smoke exposure, we analyzed the impact of the more restrictive legislation that came into force in Spain in 2011 by measuring Cd and cotinine in first morning urine samples from 83 adults in Madrid (Spain) before (2010) and after (2011) introduction of this law. Individual pair-wise comparisons showed a reduction of creatinine corrected Cotinine and Cd levels for non-active smokers, i. e. those which urinary cotinine levels are below 50 μg/L. After the application of the stricter law, cotinine levels in urine only decreased in non-active smokers who self-reported not to be exposed to second-hand smoke. The reduction in second hand smoke exposure was significantly higher in weekends (Friday to Sunday) than in working days (Monday to Thursday). The decrease in U-Cd was highly significant in non-active smokers and, in general, correlated with lower creatinine excretion. Therefore correction by creatinine could bias urinary Cd results, at least for cotinine levels higher than 500 μg/L. The biochemical/toxicological benefits detected herein support the stricter application of anti-smoking legislation and emphasize the need to raise the awareness of the population as regards exposure at home.ElsevierMinisterio de Agricultura, Alimentación y Medio Ambiente (España)Ministerio de Economía y Competitividad (España)Instituto de Salud Carlos III20202020-05-1320152015-01-0120152015-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/10096reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/100962026-06-12T12:43:37Z
dc.title.none.fl_str_mv Anti-smoking legislation and its effects on urinary cotinine and cadmium levels
title Anti-smoking legislation and its effects on urinary cotinine and cadmium levels
spellingShingle Anti-smoking legislation and its effects on urinary cotinine and cadmium levels
Sánchez-Rodríguez, Jinny E
Cadmium
Cotinine
Female
Humans
Male
Smoking
Spain
title_short Anti-smoking legislation and its effects on urinary cotinine and cadmium levels
title_full Anti-smoking legislation and its effects on urinary cotinine and cadmium levels
title_fullStr Anti-smoking legislation and its effects on urinary cotinine and cadmium levels
title_full_unstemmed Anti-smoking legislation and its effects on urinary cotinine and cadmium levels
title_sort Anti-smoking legislation and its effects on urinary cotinine and cadmium levels
dc.creator.none.fl_str_mv Sánchez-Rodríguez, Jinny E
Bartolome, Monica
Cañas Portilla, Ana Isabel
Huetos, Olga
Navarro Rivas, Carmen
Rodríguez, A Carolina
Arribas, Misericordia
Esteban-Lopez, Marta
Lopez-Herranz, Ana
Castaño, Argelia
author Sánchez-Rodríguez, Jinny E
author_facet Sánchez-Rodríguez, Jinny E
Bartolome, Monica
Cañas Portilla, Ana Isabel
Huetos, Olga
Navarro Rivas, Carmen
Rodríguez, A Carolina
Arribas, Misericordia
Esteban-Lopez, Marta
Lopez-Herranz, Ana
Castaño, Argelia
author_role author
author2 Bartolome, Monica
Cañas Portilla, Ana Isabel
Huetos, Olga
Navarro Rivas, Carmen
Rodríguez, A Carolina
Arribas, Misericordia
Esteban-Lopez, Marta
Lopez-Herranz, Ana
Castaño, Argelia
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Agricultura, Alimentación y Medio Ambiente (España)
Ministerio de Economía y Competitividad (España)
Instituto de Salud Carlos III
dc.subject.none.fl_str_mv Cadmium
Cotinine
Female
Humans
Male
Smoking
Spain
topic Cadmium
Cotinine
Female
Humans
Male
Smoking
Spain
description Anti-smoking legislation has been associated with an improvement in health indicators. Since the cadmium (Cd) body burden in the general population is markedly increased by smoke exposure, we analyzed the impact of the more restrictive legislation that came into force in Spain in 2011 by measuring Cd and cotinine in first morning urine samples from 83 adults in Madrid (Spain) before (2010) and after (2011) introduction of this law. Individual pair-wise comparisons showed a reduction of creatinine corrected Cotinine and Cd levels for non-active smokers, i. e. those which urinary cotinine levels are below 50 μg/L. After the application of the stricter law, cotinine levels in urine only decreased in non-active smokers who self-reported not to be exposed to second-hand smoke. The reduction in second hand smoke exposure was significantly higher in weekends (Friday to Sunday) than in working days (Monday to Thursday). The decrease in U-Cd was highly significant in non-active smokers and, in general, correlated with lower creatinine excretion. Therefore correction by creatinine could bias urinary Cd results, at least for cotinine levels higher than 500 μg/L. The biochemical/toxicological benefits detected herein support the stricter application of anti-smoking legislation and emphasize the need to raise the awareness of the population as regards exposure at home.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01
2015
2015-01-01
2020
2020-05-13
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/10096
url http://hdl.handle.net/20.500.12105/10096
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407829261025280
score 15,811543

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