Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review

COVID-19, an acute respiratory disease caused by SARS-CoV-2, has rapidly become a pandemic. On the other hand, obesity is also reaching dramatic dimensions and it is a risk factor for morbidity and premature mortality. Obesity has been linked to a high risk of serious-associated complications to COV...

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Detalhes bibliográficos
Autores: Moreno Fernández, Jorge, Ochoa, Julio, Ojeda Murillo, María Luisa, Nogales Bueno, Fátima, Carreras Sánchez, Olimpia, Díaz Castro, Javier
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/132126
Acesso em linha:https://hdl.handle.net/11441/132126
https://doi.org/10.1007/s13105-022-00887-4
Access Level:acceso abierto
Palavra-chave:Body mass index
COVID-19
Immunity
Inflammation
Nutrition
Obesity
Oxidative stress
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spelling Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative reviewMoreno Fernández, JorgeOchoa, JulioOjeda Murillo, María LuisaNogales Bueno, FátimaCarreras Sánchez, OlimpiaDíaz Castro, JavierBody mass indexCOVID-19ImmunityInflammationNutritionObesityOxidative stressCOVID-19, an acute respiratory disease caused by SARS-CoV-2, has rapidly become a pandemic. On the other hand, obesity is also reaching dramatic dimensions and it is a risk factor for morbidity and premature mortality. Obesity has been linked to a high risk of serious-associated complications to COVID-19, due to the increased risk of concomitant chronic diseases, which highlights the health public relevance of the topic. Obese subjects have a pro-inflammatory environment, which can further exacerbate COVID-19-induced inflammation and oxidative stress, explaining the increased risk of serious complications in these patients. Another factor that favors infection in obese patients is the high expression of ACE2 receptors in the adipose tissue. The negative impact of COVID-19 in obesity is also associated with a decrease in respiratory function, the concurrence of multiple comorbidities, a low-degree chronic inflammatory state, immunocompromised situation, and therefore a higher rate of hospitalization, mechanical ventilation, in-hospital complications such as pneumonia, and death. In this review, the link between obesity and COVID-19 was analyzed, exploring the potential common mechanisms in both diseases, with special attention to oxidative stress and inflammation, due to the crucial role of both pathways in the development of the disease.Springer NatureFisiología2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/132126https://doi.org/10.1007/s13105-022-00887-4reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésJournal of Physiology and Biochemistryhttps://doi.org/10.1007/s13105-022-00887-4info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1321262026-06-17T12:51:07Z
dc.title.none.fl_str_mv Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review
title Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review
spellingShingle Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review
Moreno Fernández, Jorge
Body mass index
COVID-19
Immunity
Inflammation
Nutrition
Obesity
Oxidative stress
title_short Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review
title_full Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review
title_fullStr Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review
title_full_unstemmed Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review
title_sort Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review
dc.creator.none.fl_str_mv Moreno Fernández, Jorge
Ochoa, Julio
Ojeda Murillo, María Luisa
Nogales Bueno, Fátima
Carreras Sánchez, Olimpia
Díaz Castro, Javier
author Moreno Fernández, Jorge
author_facet Moreno Fernández, Jorge
Ochoa, Julio
Ojeda Murillo, María Luisa
Nogales Bueno, Fátima
Carreras Sánchez, Olimpia
Díaz Castro, Javier
author_role author
author2 Ochoa, Julio
Ojeda Murillo, María Luisa
Nogales Bueno, Fátima
Carreras Sánchez, Olimpia
Díaz Castro, Javier
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Fisiología
dc.subject.none.fl_str_mv Body mass index
COVID-19
Immunity
Inflammation
Nutrition
Obesity
Oxidative stress
topic Body mass index
COVID-19
Immunity
Inflammation
Nutrition
Obesity
Oxidative stress
description COVID-19, an acute respiratory disease caused by SARS-CoV-2, has rapidly become a pandemic. On the other hand, obesity is also reaching dramatic dimensions and it is a risk factor for morbidity and premature mortality. Obesity has been linked to a high risk of serious-associated complications to COVID-19, due to the increased risk of concomitant chronic diseases, which highlights the health public relevance of the topic. Obese subjects have a pro-inflammatory environment, which can further exacerbate COVID-19-induced inflammation and oxidative stress, explaining the increased risk of serious complications in these patients. Another factor that favors infection in obese patients is the high expression of ACE2 receptors in the adipose tissue. The negative impact of COVID-19 in obesity is also associated with a decrease in respiratory function, the concurrence of multiple comorbidities, a low-degree chronic inflammatory state, immunocompromised situation, and therefore a higher rate of hospitalization, mechanical ventilation, in-hospital complications such as pneumonia, and death. In this review, the link between obesity and COVID-19 was analyzed, exploring the potential common mechanisms in both diseases, with special attention to oxidative stress and inflammation, due to the crucial role of both pathways in the development of the disease.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/132126
https://doi.org/10.1007/s13105-022-00887-4
url https://hdl.handle.net/11441/132126
https://doi.org/10.1007/s13105-022-00887-4
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Physiology and Biochemistry
https://doi.org/10.1007/s13105-022-00887-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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