Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry

Elderly people represent about the 15% of the total world population and often include a polymedicated age group with an average consumption of 5–10 pills per day. The main pharmaceuticals consumed are antianalgesics, antidiabetics, anti-parkinson compounds, anti-convulsants, drugs to treat constipa...

Descripción completa

Detalles Bibliográficos
Autores: Gómez-Canela, Cristian, Sala-Comorera, Teresa, Pueyo, Víctor, Barata Martí, Carlos, Lacorte Bruguera, Silvia
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/209253
Acceso en línea:http://hdl.handle.net/10261/209253
Access Level:acceso abierto
Palabra clave:Pharmaceuticals
Wastewater
Senior residencies
LC–MS/MS
id ES_4f89dbdfb8b2f141f36d65bc49f20717
oai_identifier_str oai:digital.csic.es:10261/209253
network_acronym_str ES
network_name_str España
repository_id_str
spelling Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometryGómez-Canela, CristianSala-Comorera, TeresaPueyo, VíctorBarata Martí, CarlosLacorte Bruguera, SilviaPharmaceuticalsWastewaterSenior residenciesLC–MS/MSElderly people represent about the 15% of the total world population and often include a polymedicated age group with an average consumption of 5–10 pills per day. The main pharmaceuticals consumed are antianalgesics, antidiabetics, anti-parkinson compounds, anti-convulsants, drugs to treat constipation and drugs to treat cancer. In this study, we have developed a multiresidue method for the analysis of 44 selected pharmaceuticals prioritized according to the foremost consumption by the elderly in effluents from senior residences. Given the complexity of these waters, method optimization included the selection of the extraction cartridge, pH and volume, and the optimization of the liquid chromatography-tandem mass spectrometry conditions to minimize matrix effects and obtain high yields. Good method performance was obtained, with recoveries between 27 and 116% and high sensitivity. The method was tested in a preliminar study to determine pharmaceuticals released in situ from the untreated effluents of the senior residences. High concentrations were detected, with levels between 0.20 and 2891 μg L −1 attributed to the high consumption of drugs in the studied residences, which gather around 100 residents. The most detected pharmaceuticals were aspirin, macrogol, levofloxacin, cyclophosphamide, diclofenac, ibuprofen, paracetamol, carbamazepine, levetiracetam, pregabalin, quetiapine, chlormetiazole, trazodone, caffeine, 2,4-dichlorobenzyl alcohol and amylmetacresol. This study describes the analytical conditions to determine the outmost consumed pharmaceuticals in wastewaters released from senior residences. © 2019This study has been financed by the SUDOE program with the project Innovec’EAU (2016-2019)/Project SOE1/P1/F0173 Interreg Sudoe funded by FEDER (http://innovec-eau.univ-perp.fr). We would like to acknowledge the associated partners of the project: Jordi Cayetano and Marc Antoni Rovira from Sant Joan de Deu (SJD) and Cinta Pascual, Arnald Pannocchia and Nuria Urquiz from Llars d’Avis de Catalunya (L’Onada). We would also like to thank the personnel from the elderly establishments for their assistance and guidance and for providing consumption data of pharmaceuticals.Peer reviewedElsevierBarata Martí, Carlos [0000-0002-3360-0729]Lacorte, Sílvia [0000-0001-7192-4057]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Preprintinfo:eu-repo/semantics/submittedVersionhttp://hdl.handle.net/10261/209253reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.jpba.2019.02.016Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2092532026-05-22T06:33:51Z
dc.title.none.fl_str_mv Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry
title Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry
spellingShingle Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry
Gómez-Canela, Cristian
Pharmaceuticals
Wastewater
Senior residencies
LC–MS/MS
title_short Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry
title_full Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry
title_fullStr Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry
title_full_unstemmed Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry
title_sort Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry
dc.creator.none.fl_str_mv Gómez-Canela, Cristian
Sala-Comorera, Teresa
Pueyo, Víctor
Barata Martí, Carlos
Lacorte Bruguera, Silvia
author Gómez-Canela, Cristian
author_facet Gómez-Canela, Cristian
Sala-Comorera, Teresa
Pueyo, Víctor
Barata Martí, Carlos
Lacorte Bruguera, Silvia
author_role author
author2 Sala-Comorera, Teresa
Pueyo, Víctor
Barata Martí, Carlos
Lacorte Bruguera, Silvia
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Barata Martí, Carlos [0000-0002-3360-0729]
Lacorte, Sílvia [0000-0001-7192-4057]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Pharmaceuticals
Wastewater
Senior residencies
LC–MS/MS
topic Pharmaceuticals
Wastewater
Senior residencies
LC–MS/MS
description Elderly people represent about the 15% of the total world population and often include a polymedicated age group with an average consumption of 5–10 pills per day. The main pharmaceuticals consumed are antianalgesics, antidiabetics, anti-parkinson compounds, anti-convulsants, drugs to treat constipation and drugs to treat cancer. In this study, we have developed a multiresidue method for the analysis of 44 selected pharmaceuticals prioritized according to the foremost consumption by the elderly in effluents from senior residences. Given the complexity of these waters, method optimization included the selection of the extraction cartridge, pH and volume, and the optimization of the liquid chromatography-tandem mass spectrometry conditions to minimize matrix effects and obtain high yields. Good method performance was obtained, with recoveries between 27 and 116% and high sensitivity. The method was tested in a preliminar study to determine pharmaceuticals released in situ from the untreated effluents of the senior residences. High concentrations were detected, with levels between 0.20 and 2891 μg L −1 attributed to the high consumption of drugs in the studied residences, which gather around 100 residents. The most detected pharmaceuticals were aspirin, macrogol, levofloxacin, cyclophosphamide, diclofenac, ibuprofen, paracetamol, carbamazepine, levetiracetam, pregabalin, quetiapine, chlormetiazole, trazodone, caffeine, 2,4-dichlorobenzyl alcohol and amylmetacresol. This study describes the analytical conditions to determine the outmost consumed pharmaceuticals in wastewaters released from senior residences. © 2019
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Preprint
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/209253
url http://hdl.handle.net/10261/209253
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.jpba.2019.02.016
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407826098520064
score 15.811543

Similares en LA Referencia