Functional neural changes associated with acquired amusia across different stages of recovery after stroke

Brain damage causing acquired amusia disrupts the functional music processing system, creating a unique opportunity to investigate the critical neural architectures of musical processing in the brain. In this longitudinal fMRI study of stroke patients (N = 41) with a 6-month follow-up, we used natur...

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Autores: Sihvonen, Aleksi J., Sarkamo, Teppo, Ripollés, Pablo, Leo, Vera, Saunavaara, Jani, Parkkola, Riitta, Rodríguez Fornells, Antoni, Soinila, Seppo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/124265
Acceso en línea:https://hdl.handle.net/2445/124265
Access Level:acceso abierto
Palabra clave:Malalties cerebrals
Trastorns de la percepció
Música
Brain diseases
Perceptual disorders
Music
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spelling Functional neural changes associated with acquired amusia across different stages of recovery after strokeSihvonen, Aleksi J.Sarkamo, TeppoRipollés, PabloLeo, VeraSaunavaara, JaniParkkola, RiittaRodríguez Fornells, AntoniSoinila, SeppoMalalties cerebralsTrastorns de la percepcióMúsicaBrain diseasesPerceptual disordersMusicBrain damage causing acquired amusia disrupts the functional music processing system, creating a unique opportunity to investigate the critical neural architectures of musical processing in the brain. In this longitudinal fMRI study of stroke patients (N = 41) with a 6-month follow-up, we used natural vocal music (sung with lyrics) and instrumental music stimuli to uncover brain activation and functional network connectivity changes associated with acquired amusia and its recovery. In the acute stage, amusic patients exhibited decreased activation in right superior temporal areas compared to non-amusic patients during instrumental music listening. During the follow-up, the activation deficits expanded to comprise a wide-spread bilateral frontal, temporal, and parietal network. The amusics showed less activation deficits to vocal music, suggesting preserved processing of singing in the amusic brain. Compared to non-recovered amusics, recovered amusics showed increased activation to instrumental music in bilateral frontoparietal areas at 3 months and in right middle and inferior frontal areas at 6 months. Amusia recovery was also associated with increased functional connectivity in right and left frontoparietal attention networks to instrumental music. Overall, our findings reveal the dynamic nature of deficient activation and connectivity patterns in acquired amusia and highlight the role of dorsal networks in amusia recovery.Nature Publishing2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/124265Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41598-017-11841-6Scientific Reports, 2017, vol. 7https://doi.org/10.1038/s41598-017-11841-6cc by (c) Sihvonen et al., 2017http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1242652026-05-27T06:46:51Z
dc.title.none.fl_str_mv Functional neural changes associated with acquired amusia across different stages of recovery after stroke
title Functional neural changes associated with acquired amusia across different stages of recovery after stroke
spellingShingle Functional neural changes associated with acquired amusia across different stages of recovery after stroke
Sihvonen, Aleksi J.
Malalties cerebrals
Trastorns de la percepció
Música
Brain diseases
Perceptual disorders
Music
title_short Functional neural changes associated with acquired amusia across different stages of recovery after stroke
title_full Functional neural changes associated with acquired amusia across different stages of recovery after stroke
title_fullStr Functional neural changes associated with acquired amusia across different stages of recovery after stroke
title_full_unstemmed Functional neural changes associated with acquired amusia across different stages of recovery after stroke
title_sort Functional neural changes associated with acquired amusia across different stages of recovery after stroke
dc.creator.none.fl_str_mv Sihvonen, Aleksi J.
Sarkamo, Teppo
Ripollés, Pablo
Leo, Vera
Saunavaara, Jani
Parkkola, Riitta
Rodríguez Fornells, Antoni
Soinila, Seppo
author Sihvonen, Aleksi J.
author_facet Sihvonen, Aleksi J.
Sarkamo, Teppo
Ripollés, Pablo
Leo, Vera
Saunavaara, Jani
Parkkola, Riitta
Rodríguez Fornells, Antoni
Soinila, Seppo
author_role author
author2 Sarkamo, Teppo
Ripollés, Pablo
Leo, Vera
Saunavaara, Jani
Parkkola, Riitta
Rodríguez Fornells, Antoni
Soinila, Seppo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties cerebrals
Trastorns de la percepció
Música
Brain diseases
Perceptual disorders
Music
topic Malalties cerebrals
Trastorns de la percepció
Música
Brain diseases
Perceptual disorders
Music
description Brain damage causing acquired amusia disrupts the functional music processing system, creating a unique opportunity to investigate the critical neural architectures of musical processing in the brain. In this longitudinal fMRI study of stroke patients (N = 41) with a 6-month follow-up, we used natural vocal music (sung with lyrics) and instrumental music stimuli to uncover brain activation and functional network connectivity changes associated with acquired amusia and its recovery. In the acute stage, amusic patients exhibited decreased activation in right superior temporal areas compared to non-amusic patients during instrumental music listening. During the follow-up, the activation deficits expanded to comprise a wide-spread bilateral frontal, temporal, and parietal network. The amusics showed less activation deficits to vocal music, suggesting preserved processing of singing in the amusic brain. Compared to non-recovered amusics, recovered amusics showed increased activation to instrumental music in bilateral frontoparietal areas at 3 months and in right middle and inferior frontal areas at 6 months. Amusia recovery was also associated with increased functional connectivity in right and left frontoparietal attention networks to instrumental music. Overall, our findings reveal the dynamic nature of deficient activation and connectivity patterns in acquired amusia and highlight the role of dorsal networks in amusia recovery.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124265
url https://hdl.handle.net/2445/124265
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-11841-6
Scientific Reports, 2017, vol. 7
https://doi.org/10.1038/s41598-017-11841-6
dc.rights.none.fl_str_mv cc by (c) Sihvonen et al., 2017
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Sihvonen et al., 2017
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing
publisher.none.fl_str_mv Nature Publishing
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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