Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes

The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without...

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Authors: Castelblanco Echavarría, Esmeralda, Betriu i Bars, M. Àngels, Hernández García, Marta, Granado Casas, Minerva, Ortega, Emilio, Soldevila, Berta, Ramírez-Morros, Anna, Franch-Nadal, Josep, Puig-Domingo, Manuel, Fernández i Giráldez, Elvira, Avogaro, Angelo, Alonso, Núria, Mauricio Puente, Dídac
Format: article
Status:Published version
Publication Date:2019
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/66809
Online Access:https://doi.org/10.3390/jcm8040424
http://hdl.handle.net/10459.1/66809
Access Level:Open access
Keyword:Type 1 diabetes
Plaque characteristics
Carotid plaque
Echogenic plaque
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spelling Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without DiabetesCastelblanco Echavarría, EsmeraldaBetriu i Bars, M. ÀngelsHernández García, MartaGranado Casas, MinervaOrtega, EmilioSoldevila, BertaRamírez-Morros, AnnaFranch-Nadal, JosepPuig-Domingo, ManuelFernández i Giráldez, ElviraAvogaro, AngeloAlonso, NúriaMauricio Puente, DídacType 1 diabetesPlaque characteristicsCarotid plaqueEchogenic plaqueThe aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without cardiovascular disease. One hundred and seven patients with T1D (49.5% women; age 54 ± 9.8 years) and 67 control subjects without diabetes who had at least one carotid plaque were included in the study. The proportion of subjects who had only echolucent plaques was reduced in the group of patients with T1D (48.6% vs. 73.1%). In contrast, the proportion with only echogenic (25.2% vs. 7.5%) and calcified plaques (9.4% vs. 1.5%) was increased compared with subjects without diabetes. Moreover, having at least one echogenic plaque was more frequent in T1D patients compared with subjects without diabetes (49.5% vs. 26.9% p = 0.005). In addition to diabetes (OR 2.28; p = 0.026), age (OR 1.06, p = 0.002) was the other variable associated with echogenic plaque existence in multiple regression analysis. Patients with T1D exhibit a differential pattern of carotid plaque type compared with subjects without diabetes, with an increased frequency of echogenic and extensively calcified plaques.This research was funded by grants from the Carlos III National Institute of Health, ISCIII (PI12/0183 and PI15/0625) with co-funding from the European Regional Development Fund (ERDF). CIBER for Diabetes and Associated Metabolic Diseases (CIBERDEM) is an initiative of ISCIII, Spain. The Health Sciences Research Institute Germans Trias i Pujol is part of the CERCA Programme/Generalitat de Catalunya.MDPI2019201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.3390/jcm8040424http://hdl.handle.net/10459.1/66809http://hdl.handle.net/10459.1/66809reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.3390/jcm8040424Journal of Clinical Medicine, 2019, vol. 8, num. 4cc-by (c) Castelblanco et al., 2019info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/668092026-05-29T05:05:01Z
dc.title.none.fl_str_mv Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
spellingShingle Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
Castelblanco Echavarría, Esmeralda
Type 1 diabetes
Plaque characteristics
Carotid plaque
Echogenic plaque
title_short Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title_full Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title_fullStr Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title_full_unstemmed Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title_sort Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
dc.creator.none.fl_str_mv Castelblanco Echavarría, Esmeralda
Betriu i Bars, M. Àngels
Hernández García, Marta
Granado Casas, Minerva
Ortega, Emilio
Soldevila, Berta
Ramírez-Morros, Anna
Franch-Nadal, Josep
Puig-Domingo, Manuel
Fernández i Giráldez, Elvira
Avogaro, Angelo
Alonso, Núria
Mauricio Puente, Dídac
author Castelblanco Echavarría, Esmeralda
author_facet Castelblanco Echavarría, Esmeralda
Betriu i Bars, M. Àngels
Hernández García, Marta
Granado Casas, Minerva
Ortega, Emilio
Soldevila, Berta
Ramírez-Morros, Anna
Franch-Nadal, Josep
Puig-Domingo, Manuel
Fernández i Giráldez, Elvira
Avogaro, Angelo
Alonso, Núria
Mauricio Puente, Dídac
author_role author
author2 Betriu i Bars, M. Àngels
Hernández García, Marta
Granado Casas, Minerva
Ortega, Emilio
Soldevila, Berta
Ramírez-Morros, Anna
Franch-Nadal, Josep
Puig-Domingo, Manuel
Fernández i Giráldez, Elvira
Avogaro, Angelo
Alonso, Núria
Mauricio Puente, Dídac
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Type 1 diabetes
Plaque characteristics
Carotid plaque
Echogenic plaque
topic Type 1 diabetes
Plaque characteristics
Carotid plaque
Echogenic plaque
description The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without cardiovascular disease. One hundred and seven patients with T1D (49.5% women; age 54 ± 9.8 years) and 67 control subjects without diabetes who had at least one carotid plaque were included in the study. The proportion of subjects who had only echolucent plaques was reduced in the group of patients with T1D (48.6% vs. 73.1%). In contrast, the proportion with only echogenic (25.2% vs. 7.5%) and calcified plaques (9.4% vs. 1.5%) was increased compared with subjects without diabetes. Moreover, having at least one echogenic plaque was more frequent in T1D patients compared with subjects without diabetes (49.5% vs. 26.9% p = 0.005). In addition to diabetes (OR 2.28; p = 0.026), age (OR 1.06, p = 0.002) was the other variable associated with echogenic plaque existence in multiple regression analysis. Patients with T1D exhibit a differential pattern of carotid plaque type compared with subjects without diabetes, with an increased frequency of echogenic and extensively calcified plaques.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm8040424
http://hdl.handle.net/10459.1/66809
http://hdl.handle.net/10459.1/66809
url https://doi.org/10.3390/jcm8040424
http://hdl.handle.net/10459.1/66809
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3390/jcm8040424
Journal of Clinical Medicine, 2019, vol. 8, num. 4
dc.rights.none.fl_str_mv cc-by (c) Castelblanco et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Castelblanco et al., 2019
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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