La vía de las lectinas en lupus y tuberculosis: polimorfismos de la MBL2 y MASP2, beneficiosos o perjudiciales/ The lectin pathway in lupus and tuberculosis: MBL2 and MASP2 polymorphisms, beneficial or harmful
[eng] MBL2 exon 1, promoter genotyping and serum MBL concentrations were determined in TB patients (79) and HHC (120) and in SLE cases (39) and controls (59). MASP-2 serum levels and 5 polymorphisms in MASP2 gene were also analyzed in 49 TB patients and 50 HHC and in the same SLE c...
| Autores: | , |
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | España |
| Institución: | Universidad de las Islas Baleares |
| Repositorio: | Biblioteca Digital de les Illes Balears |
| OAI Identifier: | tesisUIB:Losada_Lopez_Ines |
| Acceso en línea: | http://ibdigital.uib.es/greenstone/sites/oai-site/collect/tesisUIB/index/assoc/Losada_L.dir/Losada_Lopez_Ines.pdf http://ibdigital.uib.es/greenstone/library/collection/tesisUIB/document/Losada_Lopez_Ines |
| Access Level: | acceso abierto |
| Palabra clave: | Biomedical Sciences |
| Sumario: | [eng] MBL2 exon 1, promoter genotyping and serum MBL concentrations were determined in TB patients (79) and HHC (120) and in SLE cases (39) and controls (59). MASP-2 serum levels and 5 polymorphisms in MASP2 gene were also analyzed in 49 TB patients and 50 HHC and in the same SLE cases and controls as before. LXPA/HYPA, high MBL producer diplotype was significantly more frequent in HHC than in patients (16.8% vs 6.4%, p=0.03). Higher MBL levels were found in active TB than in HHC (median MBL 3420ng/mL [10-28415] and 2600 ng/mL [5-20000] respectively, p=0.02). In the SLE study LYQC/HYPD, LXPA/LYQC and LYPB/HYPD were only found in SLE patients, related to severe MBL deficiency (<100ng/mL). There was a strong correlation between MBL2 Exon 1 and promoter genotype and MBL levels. Asp105Gly MASP2 variant was the only detected among; no relationship was found between the variant and TB or SLE. |
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