Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model

15 Pág. Departamento de Reproducción animal

Detalhes bibliográficos
Autores: Yeste, Natalia, Gómez, Néstor, Vázquez-Gómez, M., Garcia-Contreras, Consolacion, Pumarola, Martí, González De Bulnes, Antonio, Bassols, Anna
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/286694
Acesso em linha:http://hdl.handle.net/10261/286694
https://api.elsevier.com/content/abstract/scopus_id/85115409783
Access Level:acceso abierto
Palavra-chave:Brain
Hippocampus
Hydroxytyrosol
Intrauterine growth restriction
Neurotransmitters
Pig
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spelling Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig ModelYeste, NataliaGómez, NéstorVázquez-Gómez, M.Garcia-Contreras, ConsolacionPumarola, MartíGonzález De Bulnes, AntonioBassols, AnnaBrainHippocampusHydroxytyrosolIntrauterine growth restrictionNeurotransmittersPig15 Pág. Departamento de Reproducción animalIntrauterine growth restriction (IUGR) refers to poor growth of a fetus during pregnancy due to deficient maternal nutrition or oxygen supply. Supplementation of a mother's diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of IUGR. In the present study, sows were treated daily with or without 1.5 mg of HTX per kilogram of feed from day 35 of pregnancy (at 30% of the total gestational period), and fetuses were sampled at day 100 of gestation. Fetuses were classified as normal body weight (NBW) or low body weight (LBW) as a consequence of IUGR, constituting four groups: NBW-Control, NBW-HTX, LBW-Control, and LBW-HTX. The brain was removed, and the hippocampus, amygdala, and prefrontal cortex were rapidly dissected. Neuronal markers were studied by immunohistochemistry, and a decrease in the number of mature neurons in the hippocampal Cornu Ammonis subfield 1 (CA1) and the Dentate Gyrus (DG) regions was observed in LBW fetuses together with a higher number of immature neurons and other alterations in neuronal morphology. Furthermore, IUGR conditions altered the neurotransmitter (NT) profile, since an increase in the serotonin (5-HT) pathway was observed in LBW fetuses. Supplementation with HTX was able to reverse the morphological and neurochemical changes, leading both characteristics to values similar to those of NBW fetuses.This research was funded by the Spanish Ministry of Economy and Competitivity (AGL2015-68463-C2-2-P to AB and projects AGL2013-48121-C3-R and AGL2016-79321-C2–1-R to AGB), co-funded by FEDER. NY and MVG are recipients of a graduate student fellowship from the Spanish FPU National Program Grant (Ministry of Science, Innovation and Universities; number FPU17/01881 and FPU14/01285) and CGC is recipient of a FPI National Program Grant (number BES-2014-070464).Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Economía y Competitividad (España)European CommissionMinisterio de Ciencia, Innovación y Universidades (España)Yeste, Natalia (0000-0003-2471-2064)Vázquez-Gómez, Marta (0000-0002-8916-2086)García-Contreras, Consolación [0000-0003-4624-2585]Pumarola, Martí (0000-0002-0935-7941)González-Bulnes, Antonio (0000-0002-0917-4475)Bassols, Anna (0000-0003-4213-2274)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/286694https://api.elsevier.com/content/abstract/scopus_id/85115409783reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/AGL2015-68463-C2-2/info:eu-repo/grantAgreement/MINECO//AGL2013-48121-C3-1-Rinfo:eu-repo/grantAgreement/MINECO//AGL2016-79321-C2–1-Rinfo:eu-repo/grantAgreement/MINECO//BES-2014-070464info:eu-repo/grantAgreement/MICIU//FPU17info:eu-repo/grantAgreement/MECD//FPU14%2F01285Antioxidants (Basel, Switzerland)https://doi.org/10.3390/antiox10101505Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2866942026-05-22T06:33:51Z
dc.title.none.fl_str_mv Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
spellingShingle Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
Yeste, Natalia
Brain
Hippocampus
Hydroxytyrosol
Intrauterine growth restriction
Neurotransmitters
Pig
title_short Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_full Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_fullStr Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_full_unstemmed Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
title_sort Polyphenols and IUGR Pregnancies: Intrauterine Growth Restriction and Hydroxytyrosol Affect the Development and Neurotransmitter Profile of the Hippocampus in a Pig Model
dc.creator.none.fl_str_mv Yeste, Natalia
Gómez, Néstor
Vázquez-Gómez, M.
Garcia-Contreras, Consolacion
Pumarola, Martí
González De Bulnes, Antonio
Bassols, Anna
author Yeste, Natalia
author_facet Yeste, Natalia
Gómez, Néstor
Vázquez-Gómez, M.
Garcia-Contreras, Consolacion
Pumarola, Martí
González De Bulnes, Antonio
Bassols, Anna
author_role author
author2 Gómez, Néstor
Vázquez-Gómez, M.
Garcia-Contreras, Consolacion
Pumarola, Martí
González De Bulnes, Antonio
Bassols, Anna
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Yeste, Natalia (0000-0003-2471-2064)
Vázquez-Gómez, Marta (0000-0002-8916-2086)
García-Contreras, Consolación [0000-0003-4624-2585]
Pumarola, Martí (0000-0002-0935-7941)
González-Bulnes, Antonio (0000-0002-0917-4475)
Bassols, Anna (0000-0003-4213-2274)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Brain
Hippocampus
Hydroxytyrosol
Intrauterine growth restriction
Neurotransmitters
Pig
topic Brain
Hippocampus
Hydroxytyrosol
Intrauterine growth restriction
Neurotransmitters
Pig
description 15 Pág. Departamento de Reproducción animal
publishDate 2021
dc.date.none.fl_str_mv 2021
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/286694
https://api.elsevier.com/content/abstract/scopus_id/85115409783
url http://hdl.handle.net/10261/286694
https://api.elsevier.com/content/abstract/scopus_id/85115409783
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/AGL2015-68463-C2-2/
info:eu-repo/grantAgreement/MINECO//AGL2013-48121-C3-1-R
info:eu-repo/grantAgreement/MINECO//AGL2016-79321-C2–1-R
info:eu-repo/grantAgreement/MINECO//BES-2014-070464
info:eu-repo/grantAgreement/MICIU//FPU17
info:eu-repo/grantAgreement/MECD//FPU14%2F01285
Antioxidants (Basel, Switzerland)
https://doi.org/10.3390/antiox10101505
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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