Cohabitation reaction-diffusion model for virus focal infections

The propagation of virus infection fronts has been typically modeled using a set of classical (noncohabitation) reaction-diffusion equations for interacting species. However, for some single-species systems it has been recently shown that noncohabitation reaction-diffusion equations may lead to unre...

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Detalles Bibliográficos
Autores: Amor, Daniel R., Fort, Joaquim
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/14083
Acceso en línea:http://hdl.handle.net/10256/14083
Access Level:acceso embargado
Palabra clave:Virosis -- Models matemàtics
Virus diseases -- Mathematical models
Teories no lineals
Nonlinear theories
Física matemàtica
Mathematical physics
Equacions de reacció-difusió
Reaction-diffusion equations
Descripción
Sumario:The propagation of virus infection fronts has been typically modeled using a set of classical (noncohabitation) reaction-diffusion equations for interacting species. However, for some single-species systems it has been recently shown that noncohabitation reaction-diffusion equations may lead to unrealistic descriptions. We argue that previous virus infection models also have this limitation, because they assume that a virion can simultaneously reproduce inside a cell and diffuse away from it. For this reason, we build a several-species cohabitation model that does not have this limitation. Furthermore, we perform a sensitivity analysis for the most relevant parameters of the model, and we compare the predicted infection speed with observed data for two different strains of the T7 virus