Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes

Purpose: To review the clinical features, risk factors, microbiological profile, and treatment regimens of fungal keratitis in Galicia, a region in Northwestern Spain with temperate humid weather. Patients and methods: A retrospective case series was employed, including patients with fungal keratiti...

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Autores: Lamas-Francis, David, Navarro, Daniel, Mansilla, Raquel, Rojas, Victoria de, Moreno, Claudio, Dios, Enrique, Rigueiro, Jesús, Álvarez, Dolores, Crego, Paloma, Touriño Peralba, Rosario, Rodríguez Ares, María Teresa
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/45066
Acceso en línea:https://hdl.handle.net/10347/45066
Access Level:acceso abierto
Palabra clave:Cornea
Fungi
Keratitis
32 Ciencias médicas
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spelling Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and OutcomesLamas-Francis, DavidNavarro, DanielMansilla, RaquelRojas, Victoria deMoreno, ClaudioDios, EnriqueRigueiro, JesúsÁlvarez, DoloresCrego, PalomaTouriño Peralba, RosarioRodríguez Ares, María TeresaCorneaFungiKeratitis32 Ciencias médicasPurpose: To review the clinical features, risk factors, microbiological profile, and treatment regimens of fungal keratitis in Galicia, a region in Northwestern Spain with temperate humid weather. Patients and methods: A retrospective case series was employed, including patients with fungal keratitis from nine hospitals within the region of Galicia, Spain, between 2010 and 2020. Data obtained from clinical records were analysed. Results: Out of 654 cases of infectious keratitis, 77 cases (9.9%) were identified as fungal keratitis. The median age of affected patients was 68.0 years, with a higher incidence in rural areas (62.3%). Candida spp. infections were the most frequent type (55.8%) and were associated with a higher median age than were the non-dermatophyte mould infections. The primary risk factors included steroid eyedrop use (29.9%), recent keratoplasty (18.2%), ocular trauma (19.5%), and contact with vegetable matter (11.7%). Most ulcers displayed stromal involvement, and 37.7% presented corneal thinning. The median duration of infection was longer in fungal than in bacterial keratitis, and surgical intervention was required in 48.1% of cases. Conclusions: Fungal keratitis, mainly involving Candida spp., accounted for 9.9% of microbial keratitis cases in Galicia, Spain, with significant risk factors being topical steroid use, ocular trauma, and contact with vegetable matter. Delayed diagnosis often resulted in poor outcomes, highlighting the need for early detection through awareness and new technologies to improve prognosis.MDPIUniversidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-CirúrxicasUniversidade de Santiago de Compostela. Facultade de Medicina e Odontoloxía20242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10347/45066reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/450662026-06-15T12:47:27Z
dc.title.none.fl_str_mv Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes
title Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes
spellingShingle Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes
Lamas-Francis, David
Cornea
Fungi
Keratitis
32 Ciencias médicas
title_short Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes
title_full Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes
title_fullStr Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes
title_full_unstemmed Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes
title_sort Fungal Keratitis in Northwestern Spain: Epidemiology, Risk Factors and Outcomes
dc.creator.none.fl_str_mv Lamas-Francis, David
Navarro, Daniel
Mansilla, Raquel
Rojas, Victoria de
Moreno, Claudio
Dios, Enrique
Rigueiro, Jesús
Álvarez, Dolores
Crego, Paloma
Touriño Peralba, Rosario
Rodríguez Ares, María Teresa
author Lamas-Francis, David
author_facet Lamas-Francis, David
Navarro, Daniel
Mansilla, Raquel
Rojas, Victoria de
Moreno, Claudio
Dios, Enrique
Rigueiro, Jesús
Álvarez, Dolores
Crego, Paloma
Touriño Peralba, Rosario
Rodríguez Ares, María Teresa
author_role author
author2 Navarro, Daniel
Mansilla, Raquel
Rojas, Victoria de
Moreno, Claudio
Dios, Enrique
Rigueiro, Jesús
Álvarez, Dolores
Crego, Paloma
Touriño Peralba, Rosario
Rodríguez Ares, María Teresa
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
Universidade de Santiago de Compostela. Facultade de Medicina e Odontoloxía
dc.subject.none.fl_str_mv Cornea
Fungi
Keratitis
32 Ciencias médicas
topic Cornea
Fungi
Keratitis
32 Ciencias médicas
description Purpose: To review the clinical features, risk factors, microbiological profile, and treatment regimens of fungal keratitis in Galicia, a region in Northwestern Spain with temperate humid weather. Patients and methods: A retrospective case series was employed, including patients with fungal keratitis from nine hospitals within the region of Galicia, Spain, between 2010 and 2020. Data obtained from clinical records were analysed. Results: Out of 654 cases of infectious keratitis, 77 cases (9.9%) were identified as fungal keratitis. The median age of affected patients was 68.0 years, with a higher incidence in rural areas (62.3%). Candida spp. infections were the most frequent type (55.8%) and were associated with a higher median age than were the non-dermatophyte mould infections. The primary risk factors included steroid eyedrop use (29.9%), recent keratoplasty (18.2%), ocular trauma (19.5%), and contact with vegetable matter (11.7%). Most ulcers displayed stromal involvement, and 37.7% presented corneal thinning. The median duration of infection was longer in fungal than in bacterial keratitis, and surgical intervention was required in 48.1% of cases. Conclusions: Fungal keratitis, mainly involving Candida spp., accounted for 9.9% of microbial keratitis cases in Galicia, Spain, with significant risk factors being topical steroid use, ocular trauma, and contact with vegetable matter. Delayed diagnosis often resulted in poor outcomes, highlighting the need for early detection through awareness and new technologies to improve prognosis.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10347/45066
url https://hdl.handle.net/10347/45066
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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