Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring

Backgroud: Prenatal alcohol exposure is a leading cause of neurobehavioral and neurocognitive deficits collectively known as fetal alcohol spectrum disorders (FASD), including eating disorders and increased risk for substance abuse as very common issues. In this context, the present study aimed to a...

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Autores: Duart Castells, Leticia, Cantacorps, Lídia, López-Arnau, Raúl, Montagud-Romero, Sandra, Puster, Brigitte, Mera Nanín, Paula, Serra i Cucurull, Dolors, Camarasa García, Jordi, Pubill Sánchez, David, Valverde, Olga, Escubedo Rafa, Elena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173721
Acceso en línea:https://hdl.handle.net/2445/173721
Access Level:acceso abierto
Palabra clave:Alcohol
Cocaïna
Dieta
Ratolins (Animals de laboratori)
Cocaine
Diet
Mice (Laboratory animals)
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spelling Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice OffspringDuart Castells, LeticiaCantacorps, LídiaLópez-Arnau, RaúlMontagud-Romero, SandraPuster, BrigitteMera Nanín, PaulaSerra i Cucurull, DolorsCamarasa García, JordiPubill Sánchez, DavidValverde, OlgaEscubedo Rafa, ElenaAlcoholCocaïnaDietaRatolins (Animals de laboratori)AlcoholCocaineDietMice (Laboratory animals)Backgroud: Prenatal alcohol exposure is a leading cause of neurobehavioral and neurocognitive deficits collectively known as fetal alcohol spectrum disorders (FASD), including eating disorders and increased risk for substance abuse as very common issues. In this context, the present study aimed to assess the interaction between alcohol exposure during gestation and lactation periods (PLAE) and a high fat diet (HFD) during childhood and adolescence. Methods: Pregnant C57BL/6 mice underwent a procedure for alcohol binge drinking during gestation and lactation periods. Subsequently, PLAE female offspring were fed with a HFD for 8 weeks and thereafter, nutrition-related parameters as well as their response to cocaine were assessed. Results: In our model, feeding young females with a HFD increased their triglyceride blood levels but did not induce an overweight compared to those fed with a standard diet. Moreover, PLAE affected how females responded to the fatty diet as they consumed less amount of food than water-exposed offspring, consistent with a lower gain of body weight. HFD increased the psychostimulant effects of cocaine. Surprisingly, PLAE reduced the locomotor responses to cocaine without modifying cocaine-induced reward. Moreover, PLAE prevented the striatal overexpression of cannabinoid 1 receptors induced by a HFD and induced an alteration of myelin damage biomarker in the prefrontal cortex, an effect that was mitigated by a HFD-based feeding. Conclusion: Therefore, in female offspring, some effects triggered by one of these factors, PLAE or a HFD, were blunted by the other, suggesting a close interaction between the involved mechanisms.Oxford University Press2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/173721Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1093/ijnp/pyaa074International Journal of Neuropsychopharmacology, 2020, vol. 24, num. 1, p. 77-88https://doi.org/10.1093/ijnp/pyaa074cc-by-nc (c) Duart Castells, Leticia et al., 2020http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1737212026-05-29T05:05:01Z
dc.title.none.fl_str_mv Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring
title Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring
spellingShingle Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring
Duart Castells, Leticia
Alcohol
Cocaïna
Dieta
Ratolins (Animals de laboratori)
Alcohol
Cocaine
Diet
Mice (Laboratory animals)
title_short Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring
title_full Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring
title_fullStr Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring
title_full_unstemmed Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring
title_sort Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring
dc.creator.none.fl_str_mv Duart Castells, Leticia
Cantacorps, Lídia
López-Arnau, Raúl
Montagud-Romero, Sandra
Puster, Brigitte
Mera Nanín, Paula
Serra i Cucurull, Dolors
Camarasa García, Jordi
Pubill Sánchez, David
Valverde, Olga
Escubedo Rafa, Elena
author Duart Castells, Leticia
author_facet Duart Castells, Leticia
Cantacorps, Lídia
López-Arnau, Raúl
Montagud-Romero, Sandra
Puster, Brigitte
Mera Nanín, Paula
Serra i Cucurull, Dolors
Camarasa García, Jordi
Pubill Sánchez, David
Valverde, Olga
Escubedo Rafa, Elena
author_role author
author2 Cantacorps, Lídia
López-Arnau, Raúl
Montagud-Romero, Sandra
Puster, Brigitte
Mera Nanín, Paula
Serra i Cucurull, Dolors
Camarasa García, Jordi
Pubill Sánchez, David
Valverde, Olga
Escubedo Rafa, Elena
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alcohol
Cocaïna
Dieta
Ratolins (Animals de laboratori)
Alcohol
Cocaine
Diet
Mice (Laboratory animals)
topic Alcohol
Cocaïna
Dieta
Ratolins (Animals de laboratori)
Alcohol
Cocaine
Diet
Mice (Laboratory animals)
description Backgroud: Prenatal alcohol exposure is a leading cause of neurobehavioral and neurocognitive deficits collectively known as fetal alcohol spectrum disorders (FASD), including eating disorders and increased risk for substance abuse as very common issues. In this context, the present study aimed to assess the interaction between alcohol exposure during gestation and lactation periods (PLAE) and a high fat diet (HFD) during childhood and adolescence. Methods: Pregnant C57BL/6 mice underwent a procedure for alcohol binge drinking during gestation and lactation periods. Subsequently, PLAE female offspring were fed with a HFD for 8 weeks and thereafter, nutrition-related parameters as well as their response to cocaine were assessed. Results: In our model, feeding young females with a HFD increased their triglyceride blood levels but did not induce an overweight compared to those fed with a standard diet. Moreover, PLAE affected how females responded to the fatty diet as they consumed less amount of food than water-exposed offspring, consistent with a lower gain of body weight. HFD increased the psychostimulant effects of cocaine. Surprisingly, PLAE reduced the locomotor responses to cocaine without modifying cocaine-induced reward. Moreover, PLAE prevented the striatal overexpression of cannabinoid 1 receptors induced by a HFD and induced an alteration of myelin damage biomarker in the prefrontal cortex, an effect that was mitigated by a HFD-based feeding. Conclusion: Therefore, in female offspring, some effects triggered by one of these factors, PLAE or a HFD, were blunted by the other, suggesting a close interaction between the involved mechanisms.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173721
url https://hdl.handle.net/2445/173721
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1093/ijnp/pyaa074
International Journal of Neuropsychopharmacology, 2020, vol. 24, num. 1, p. 77-88
https://doi.org/10.1093/ijnp/pyaa074
dc.rights.none.fl_str_mv cc-by-nc (c) Duart Castells, Leticia et al., 2020
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Duart Castells, Leticia et al., 2020
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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