Drosophila melanogaster Hedgehog cooperates with Frazzled to guide axons through a noncanonical signalling pathway
© 2015 Elsevier Ireland Ltd. We report that the morphogen Hedgehog (Hh) is an axonal chemoattractant in the midline of Drosophila melanogaster embryos. Hh is present in the ventral nerve cord during axonal guidance and overexpression of hh in the midline causes ectopic midline crossing of FasIIposit...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/124500 |
| Acceso en línea: | http://hdl.handle.net/10261/124500 |
| Access Level: | acceso abierto |
| Palabra clave: | Hedgehog Axons Drosophila Patched Frazzled DCC |
| Sumario: | © 2015 Elsevier Ireland Ltd. We report that the morphogen Hedgehog (Hh) is an axonal chemoattractant in the midline of Drosophila melanogaster embryos. Hh is present in the ventral nerve cord during axonal guidance and overexpression of hh in the midline causes ectopic midline crossing of FasIIpositive axonal tracts. In addition, we show that Hh influences axonal guidance via a noncanonical signalling pathway dependent on Ptc. Our results reveal that the Hh pathway cooperates with the Netrin/Frazzled pathway to guide axons through the midline in invertebrates. |
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