PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention
Background: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have represented an important change in the management of hypercholesterolemia, although, until now, they have barely been used. Without PCSK9i, many patients with atherosclerotic cardiovascular disease (CVD) or those at v...
| Autores: | , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/70092 |
| Acceso en línea: | http://hdl.handle.net/10230/70092 http://dx.doi.org/10.1186/s12944-024-02283-x |
| Access Level: | acceso abierto |
| Palabra clave: | Familial hypercholesterolemia LDL-cholesterol PCSK9 inhibitors Primary prevention Secondary prevention |
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oai:recercat.cat:10230/70092 |
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España |
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PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention |
| title |
PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention |
| spellingShingle |
PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention Marco-Benedí, Victoria Familial hypercholesterolemia LDL-cholesterol PCSK9 inhibitors Primary prevention Secondary prevention |
| title_short |
PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention |
| title_full |
PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention |
| title_fullStr |
PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention |
| title_full_unstemmed |
PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention |
| title_sort |
PCSK9 inhibitors on the management of primary and secondary cardiovascular prevention |
| dc.creator.none.fl_str_mv |
Marco-Benedí, Victoria Sánchez-Hernández, Rosa M. Díaz, José Luis Jarauta, Estíbaliz Suárez-Tembra, Manuel Pintó Sala, Xavier Morillas, Carlos Plana, Nuria Pedro-Botet, Juan Carlos Civeira, Fernando |
| author |
Marco-Benedí, Victoria |
| author_facet |
Marco-Benedí, Victoria Sánchez-Hernández, Rosa M. Díaz, José Luis Jarauta, Estíbaliz Suárez-Tembra, Manuel Pintó Sala, Xavier Morillas, Carlos Plana, Nuria Pedro-Botet, Juan Carlos Civeira, Fernando |
| author_role |
author |
| author2 |
Sánchez-Hernández, Rosa M. Díaz, José Luis Jarauta, Estíbaliz Suárez-Tembra, Manuel Pintó Sala, Xavier Morillas, Carlos Plana, Nuria Pedro-Botet, Juan Carlos Civeira, Fernando |
| author2_role |
author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Familial hypercholesterolemia LDL-cholesterol PCSK9 inhibitors Primary prevention Secondary prevention |
| topic |
Familial hypercholesterolemia LDL-cholesterol PCSK9 inhibitors Primary prevention Secondary prevention |
| description |
Background: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have represented an important change in the management of hypercholesterolemia, although, until now, they have barely been used. Without PCSK9i, many patients with atherosclerotic cardiovascular disease (CVD) or those at very high risk do not reach their therapeutic LDLc objectives. Objective: The analysis aimed to examine the clinical and biochemical characteristics of subjects receiving PCSK9i treatment in the Dyslipidemia Registry of the Spanish Atherosclerosis Society. Methods: All consecutive subjects aged ≥ 18 years from different Lipid Units included in the Dyslipidemia Registry of the SEA were analyzed. Inclusion criteria consisted of unrelated patients aged ≥ 18 at the time of inclusion with hypercholesterolemia (LDL-C ≥ 130 mg/dL or non-HDL-C ≥ 160 mg/dL after the exclusion of secondary causes) who were studied for at least two years after inclusion. Participants' baseline and final visit clinical and biochemical characteristics were analyzed based on whether they were on primary or secondary prevention and whether they were taking PCSK9i at the end of follow-up. Results: Eight hundred twenty-nine patients were analyzed, 7014 patients in primary prevention and 1281 in secondary prevention at baseline. 4127 subjects completed the required follow-up for the final analysis. The median follow-up duration was 7 years (IQR 3.0-10.0). Five hundred patients (12.1%) were taking PCSK9i at the end of the follow-up. The percentage of PCSK9i use reached 35.6% (n = 201) and 8.7% (n = 318) in subjects with and without CVD, respectively. Subjects on PCSK9i and oral lipid-lowering agents with and without CVD achieved LDLc reductions of 80.3% and 75.1%, respectively, concerning concentrations without lipid-lowering drugs. Factors associated with PCSK9i use included increasing age, LDLc without lipid-lowering drugs and the Dutch Lipid Clinic Network (DLCN) score. However, hypertension, diabetes, smoking, and LDLc after oral lipid-lowering drugs were not independent factors associated with PCSK9i prescription. In subjects with CVD, the use of PCSK9i was higher in men than in women (an odds ratio of 1.613, P = 0.048). Conclusions: Approximately one-third of CVD patients received PCSK9i at the end of follow-up. The use of PCSK9i was more focused on baseline LDLc concentrations rather than on CVD risk. Women received less PCSK9i in secondary prevention compared to men. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2025 2025 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/70092 http://dx.doi.org/10.1186/s12944-024-02283-x http://hdl.handle.net/10230/70092 |
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http://hdl.handle.net/10230/70092 http://dx.doi.org/10.1186/s12944-024-02283-x |
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Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Lipids Health Dis. 2024 Sep 10;23(1):290 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
BioMed Central |
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BioMed Central |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869407803091714048 |
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PCSK9 inhibitors on the management of primary and secondary cardiovascular preventionMarco-Benedí, VictoriaSánchez-Hernández, Rosa M.Díaz, José LuisJarauta, EstíbalizSuárez-Tembra, ManuelPintó Sala, XavierMorillas, CarlosPlana, NuriaPedro-Botet, Juan CarlosCiveira, FernandoFamilial hypercholesterolemiaLDL-cholesterolPCSK9 inhibitorsPrimary preventionSecondary preventionBackground: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have represented an important change in the management of hypercholesterolemia, although, until now, they have barely been used. Without PCSK9i, many patients with atherosclerotic cardiovascular disease (CVD) or those at very high risk do not reach their therapeutic LDLc objectives. Objective: The analysis aimed to examine the clinical and biochemical characteristics of subjects receiving PCSK9i treatment in the Dyslipidemia Registry of the Spanish Atherosclerosis Society. Methods: All consecutive subjects aged ≥ 18 years from different Lipid Units included in the Dyslipidemia Registry of the SEA were analyzed. Inclusion criteria consisted of unrelated patients aged ≥ 18 at the time of inclusion with hypercholesterolemia (LDL-C ≥ 130 mg/dL or non-HDL-C ≥ 160 mg/dL after the exclusion of secondary causes) who were studied for at least two years after inclusion. Participants' baseline and final visit clinical and biochemical characteristics were analyzed based on whether they were on primary or secondary prevention and whether they were taking PCSK9i at the end of follow-up. Results: Eight hundred twenty-nine patients were analyzed, 7014 patients in primary prevention and 1281 in secondary prevention at baseline. 4127 subjects completed the required follow-up for the final analysis. The median follow-up duration was 7 years (IQR 3.0-10.0). Five hundred patients (12.1%) were taking PCSK9i at the end of the follow-up. The percentage of PCSK9i use reached 35.6% (n = 201) and 8.7% (n = 318) in subjects with and without CVD, respectively. Subjects on PCSK9i and oral lipid-lowering agents with and without CVD achieved LDLc reductions of 80.3% and 75.1%, respectively, concerning concentrations without lipid-lowering drugs. Factors associated with PCSK9i use included increasing age, LDLc without lipid-lowering drugs and the Dutch Lipid Clinic Network (DLCN) score. However, hypertension, diabetes, smoking, and LDLc after oral lipid-lowering drugs were not independent factors associated with PCSK9i prescription. In subjects with CVD, the use of PCSK9i was higher in men than in women (an odds ratio of 1.613, P = 0.048). Conclusions: Approximately one-third of CVD patients received PCSK9i at the end of follow-up. The use of PCSK9i was more focused on baseline LDLc concentrations rather than on CVD risk. Women received less PCSK9i in secondary prevention compared to men.BioMed Central202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/70092http://dx.doi.org/10.1186/s12944-024-02283-xhttp://hdl.handle.net/10230/70092reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésLipids Health Dis. 2024 Sep 10;23(1):290© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/700922026-05-29T05:05:01Z |
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