Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome
Background: Excess circulating endocannabinoids (eCBs) and imbalanced N-acylethanolamines (NAEs) related eCBs abundance could influence dietary weight loss success. We aimed to examine sex differences in the impact of a 3-years Mediterranean diet (MedDiet) intervention on circulating eCBs, NAEs and...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dnet:dadun_______::89838f7892d5ac078c3341a0d915febf |
| Acceso en línea: | https://hdl.handle.net/10171/124507 |
| Access Level: | acceso abierto |
| Palabra clave: | 2-arachidonoylglycerol (2-AG) Mediterranean diet Anandamide (AEA) Endocannabinoids Insulin resistance Metabolic syndrome Sex differences Weight loss |
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Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome |
| title |
Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome |
| spellingShingle |
Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome Soldevila-Domenech, N. (Natalia)|||/items/a9a56824-9a47-4934-b654-59e82af8d7d9 2-arachidonoylglycerol (2-AG) Mediterranean diet Anandamide (AEA) Endocannabinoids Insulin resistance Metabolic syndrome Sex differences Weight loss |
| title_short |
Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome |
| title_full |
Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome |
| title_fullStr |
Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome |
| title_full_unstemmed |
Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome |
| title_sort |
Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndrome |
| dc.creator.none.fl_str_mv |
Soldevila-Domenech, N. (Natalia)|||/items/a9a56824-9a47-4934-b654-59e82af8d7d9 Pastor, A. (Antoni)|||/items/801e18d6-516a-4d44-9725-8fdf28c1d869 Sala-Vila, A. (Aleix)|||/items/1ad50907-4d92-418e-87a6-5bddb69c29f0 Lázaro, I. (Iolanda)|||/items/f4655c68-f23b-4ad7-8d7d-5bba6fa8b225 Boronat, A. (Anna)|||/items/2ce0dabe-cf89-4687-a927-2a4f60ebc2bc Muñoz, D. (Daniel)|||/items/d2a2ce0f-ce15-4722-9f26-084329786460 Castañer, O. (Olga)|||/items/177ed76c-c237-4ac1-99b7-445c1b2e49dc Fagundo, B. (Beatriz)|||/items/a8436f19-9fc9-4bae-9831-ff849ffa56b2 Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Fernandez-Aranda, F. (Fernando)|||/items/797e1a75-1ed2-4ee6-9666-f6de61f027b7 Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Torre, R. (Rafael) de la|||/items/8ffc37a7-8bbf-4973-8257-72f8c379cd46 |
| author |
Soldevila-Domenech, N. (Natalia)|||/items/a9a56824-9a47-4934-b654-59e82af8d7d9 |
| author_facet |
Soldevila-Domenech, N. (Natalia)|||/items/a9a56824-9a47-4934-b654-59e82af8d7d9 Pastor, A. (Antoni)|||/items/801e18d6-516a-4d44-9725-8fdf28c1d869 Sala-Vila, A. (Aleix)|||/items/1ad50907-4d92-418e-87a6-5bddb69c29f0 Lázaro, I. (Iolanda)|||/items/f4655c68-f23b-4ad7-8d7d-5bba6fa8b225 Boronat, A. (Anna)|||/items/2ce0dabe-cf89-4687-a927-2a4f60ebc2bc Muñoz, D. (Daniel)|||/items/d2a2ce0f-ce15-4722-9f26-084329786460 Castañer, O. (Olga)|||/items/177ed76c-c237-4ac1-99b7-445c1b2e49dc Fagundo, B. (Beatriz)|||/items/a8436f19-9fc9-4bae-9831-ff849ffa56b2 Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Fernandez-Aranda, F. (Fernando)|||/items/797e1a75-1ed2-4ee6-9666-f6de61f027b7 Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Torre, R. (Rafael) de la|||/items/8ffc37a7-8bbf-4973-8257-72f8c379cd46 |
| author_role |
author |
| author2 |
Pastor, A. (Antoni)|||/items/801e18d6-516a-4d44-9725-8fdf28c1d869 Sala-Vila, A. (Aleix)|||/items/1ad50907-4d92-418e-87a6-5bddb69c29f0 Lázaro, I. (Iolanda)|||/items/f4655c68-f23b-4ad7-8d7d-5bba6fa8b225 Boronat, A. (Anna)|||/items/2ce0dabe-cf89-4687-a927-2a4f60ebc2bc Muñoz, D. (Daniel)|||/items/d2a2ce0f-ce15-4722-9f26-084329786460 Castañer, O. (Olga)|||/items/177ed76c-c237-4ac1-99b7-445c1b2e49dc Fagundo, B. (Beatriz)|||/items/a8436f19-9fc9-4bae-9831-ff849ffa56b2 Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41 Fernandez-Aranda, F. (Fernando)|||/items/797e1a75-1ed2-4ee6-9666-f6de61f027b7 Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7 Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6 Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6b Torre, R. (Rafael) de la|||/items/8ffc37a7-8bbf-4973-8257-72f8c379cd46 |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
2-arachidonoylglycerol (2-AG) Mediterranean diet Anandamide (AEA) Endocannabinoids Insulin resistance Metabolic syndrome Sex differences Weight loss |
| topic |
2-arachidonoylglycerol (2-AG) Mediterranean diet Anandamide (AEA) Endocannabinoids Insulin resistance Metabolic syndrome Sex differences Weight loss |
| description |
Background: Excess circulating endocannabinoids (eCBs) and imbalanced N-acylethanolamines (NAEs) related eCBs abundance could influence dietary weight loss success. We aimed to examine sex differences in the impact of a 3-years Mediterranean diet (MedDiet) intervention on circulating eCBs, NAEs and their precursor fatty acids, and to analyze the interplay between changes in eCBs or NAEs ratios, insulin resistance and the achievement of clinically meaningful weight reductions. Methods: Prospective cohort study in a subsample of N = 105 participants (54.3% women; 65.6 ± 4.6 years) with overweight or obesity and metabolic syndrome that underwent a 3-years MedDiet intervention (PREDIMED-Plus study). Plasma eCBs and NAEs, including 2-arachidonoylglycerol (2-AG), anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), fatty acids, diet, glycemic homeostasis (including the assessment of insulin resistance-HOMA-IR), and cardiovascular risk markers were monitored (at 0-6-12-36 months). Results: Mediterranean diet adherence increased in both sexes and remained high during the 3 years of follow-up. Reductions in body weight, glycemic and cardiovascular parameters were larger in men than in women. Women presented higher concentrations of NAEs than men throughout the study. In both sexes, AEA and other NAEs (including OEA, and PEA) decreased after 6 months (for AEA: -4.9%), whereas the ratio OEA/AEA increased after 1 year (+5.8%). Changes in 2-AG (-3.9%) and the ratio OEA/PEA (+8.2%) persisted over the 3 years of follow-up. In women, 6-months changes in AEA (OR = 0.65) and the ratio OEA/AEA (OR = 3.28) were associated with the achievement of 8% weight reductions and correlated with HOMA-IR changes (r = 0.29 and r = -0.34). In men, OEA/PEA changes were associated with 8% weight reductions (OR = 2.62) and correlated with HOMA-IR changes (r = -0.32). Conclusion: A 3-years MedDiet intervention modulated plasma concentrations of eCBs and NAEs. Changes in AEA and in the relative abundance of NAEs were associated with clinically meaningful weight reductions. However, marked sex differences were identified in eCBs and NAEs, as well as in the efficacy of the intervention in terms of glycemic and cardiovascular parameters, which could be related to post-menopause alterations in glucose metabolism. These findings support a sex-balanced research strategy for a better understanding of the mechanisms underlying the regulation of body weight loss. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-01-01 2022 2022-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/124507 |
| url |
https://hdl.handle.net/10171/124507 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
| publisher.none.fl_str_mv |
Frontiers Media S.A. |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869407790034845696 |
| spelling |
Sex differences in endocannabinoids during 3 years of Mediterranean diet intervention: Association with insulin resistance and weight loss in a population with metabolic syndromeSoldevila-Domenech, N. (Natalia)|||/items/a9a56824-9a47-4934-b654-59e82af8d7d9Pastor, A. (Antoni)|||/items/801e18d6-516a-4d44-9725-8fdf28c1d869Sala-Vila, A. (Aleix)|||/items/1ad50907-4d92-418e-87a6-5bddb69c29f0Lázaro, I. (Iolanda)|||/items/f4655c68-f23b-4ad7-8d7d-5bba6fa8b225Boronat, A. (Anna)|||/items/2ce0dabe-cf89-4687-a927-2a4f60ebc2bcMuñoz, D. (Daniel)|||/items/d2a2ce0f-ce15-4722-9f26-084329786460Castañer, O. (Olga)|||/items/177ed76c-c237-4ac1-99b7-445c1b2e49dcFagundo, B. (Beatriz)|||/items/a8436f19-9fc9-4bae-9831-ff849ffa56b2Corella, D. (Dolores)|||/items/edf5ac4d-018f-446d-aa6e-2448c41a1e41Fernandez-Aranda, F. (Fernando)|||/items/797e1a75-1ed2-4ee6-9666-f6de61f027b7Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Salas-Salvado, J. (Jordi)|||/items/e2fc08dd-d21f-475b-83fa-157f0b0067e6Fito, M. (Montserrat)|||/items/7de631e9-926b-4b1a-9964-0c0ca699df6bTorre, R. (Rafael) de la|||/items/8ffc37a7-8bbf-4973-8257-72f8c379cd462-arachidonoylglycerol (2-AG)Mediterranean dietAnandamide (AEA)EndocannabinoidsInsulin resistanceMetabolic syndromeSex differencesWeight lossBackground: Excess circulating endocannabinoids (eCBs) and imbalanced N-acylethanolamines (NAEs) related eCBs abundance could influence dietary weight loss success. We aimed to examine sex differences in the impact of a 3-years Mediterranean diet (MedDiet) intervention on circulating eCBs, NAEs and their precursor fatty acids, and to analyze the interplay between changes in eCBs or NAEs ratios, insulin resistance and the achievement of clinically meaningful weight reductions. Methods: Prospective cohort study in a subsample of N = 105 participants (54.3% women; 65.6 ± 4.6 years) with overweight or obesity and metabolic syndrome that underwent a 3-years MedDiet intervention (PREDIMED-Plus study). Plasma eCBs and NAEs, including 2-arachidonoylglycerol (2-AG), anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA), fatty acids, diet, glycemic homeostasis (including the assessment of insulin resistance-HOMA-IR), and cardiovascular risk markers were monitored (at 0-6-12-36 months). Results: Mediterranean diet adherence increased in both sexes and remained high during the 3 years of follow-up. Reductions in body weight, glycemic and cardiovascular parameters were larger in men than in women. Women presented higher concentrations of NAEs than men throughout the study. In both sexes, AEA and other NAEs (including OEA, and PEA) decreased after 6 months (for AEA: -4.9%), whereas the ratio OEA/AEA increased after 1 year (+5.8%). Changes in 2-AG (-3.9%) and the ratio OEA/PEA (+8.2%) persisted over the 3 years of follow-up. In women, 6-months changes in AEA (OR = 0.65) and the ratio OEA/AEA (OR = 3.28) were associated with the achievement of 8% weight reductions and correlated with HOMA-IR changes (r = 0.29 and r = -0.34). In men, OEA/PEA changes were associated with 8% weight reductions (OR = 2.62) and correlated with HOMA-IR changes (r = -0.32). Conclusion: A 3-years MedDiet intervention modulated plasma concentrations of eCBs and NAEs. Changes in AEA and in the relative abundance of NAEs were associated with clinically meaningful weight reductions. However, marked sex differences were identified in eCBs and NAEs, as well as in the efficacy of the intervention in terms of glycemic and cardiovascular parameters, which could be related to post-menopause alterations in glucose metabolism. These findings support a sex-balanced research strategy for a better understanding of the mechanisms underlying the regulation of body weight loss.Frontiers Media S.A.Dadun. Depósito Académico Digital Universidad de Navarra20222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/124507reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dnet:dadun_______::89838f7892d5ac078c3341a0d915febf2026-06-21T12:47:57Z |
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15,811543 |