Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder

Although the etiology of obsessive-compulsive disorder (OCD) is largely unknown, it is accepted that OCD is a complex disorder. There is a known bi-directional interaction between the gut microbiome and brain activity. Several authors have reported associations between changes in gut microbiota and...

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Autores: Domènech, Laura, Willis, Jesse, Alemany-Navarro, María, Morey i Ramonell, Marta, Real, Eva, Escaramís Babiano, Geòrgia, Bertolín Triquell, Sara, Sánchez Chinchilla, Daniel, Balcells Comas, Susana, Segalàs Cosi, Cinto, Estivill, Xavier, 1955-, Menchón Magriñá, José Manuel, Gabaldón, Toni, Alonso Ortega, María del Pino, Rabionet Janssen, Raquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183876
Acceso en línea:https://hdl.handle.net/2445/183876
Access Level:acceso abierto
Palabra clave:Neurosi obsessiva
Microbiologia oral
Excrements
Obsessive-compulsive disorder
Oral microbiology
Feces
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spelling Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorderDomènech, LauraWillis, JesseAlemany-Navarro, MaríaMorey i Ramonell, MartaReal, EvaEscaramís Babiano, GeòrgiaBertolín Triquell, SaraSánchez Chinchilla, DanielBalcells Comas, SusanaSegalàs Cosi, CintoEstivill, Xavier, 1955-Menchón Magriñá, José ManuelGabaldón, ToniAlonso Ortega, María del PinoRabionet Janssen, RaquelNeurosi obsessivaMicrobiologia oralExcrementsObsessive-compulsive disorderOral microbiologyFecesAlthough the etiology of obsessive-compulsive disorder (OCD) is largely unknown, it is accepted that OCD is a complex disorder. There is a known bi-directional interaction between the gut microbiome and brain activity. Several authors have reported associations between changes in gut microbiota and neuropsychiatric disorders, including depression or autism. Furthermore, a pediatric-onset neuropsychiatric OCD-related syndrome occurs after streptococcal infection, which might indicate that exposure to certain microbes could be involved in OCD susceptibility. However, only one study has investigated the microbiome of OCD patients to date. We performed 16S ribosomal RNA gene-based metagenomic sequencing to analyze the stool and oropharyngeal microbiome composition of 32 OCD cases and 32 age and gender matched controls. We estimated different α- and β-diversity measures and performed LEfSe and Wilcoxon tests to assess differences in bacterial distribution. OCD stool samples showed a trend towards lower bacterial α-diversity, as well as an increase of the relative abundance of Rikenellaceae, particularly of the genus Alistipes, and lower relative abundance of Prevotellaceae, and two genera within the Lachnospiraceae: Agathobacer and Coprococcus. However, we did not observe a different Bacteroidetes to Firmicutes ratio between OCD cases and controls. Analysis of the oropharyngeal microbiome composition showed a lower Fusobacteria to Actinobacteria ratio in OCD cases. In conclusion, we observed an imbalance in the gut and oropharyngeal microbiomes of OCD cases, including, in stool, an increase of bacteria from the Rikenellaceae family, associated with gut inflammation, and a decrease of bacteria from the Coprococcus genus, associated with DOPAC synthesis.Nature Publishing Group2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183876Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41598-022-05480-9Scientific Reports, 2022https://doi.org/10.1038/s41598-022-05480-9cc-by (c) Domènech, Laura et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1838762026-05-27T06:46:51Z
dc.title.none.fl_str_mv Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
title Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
spellingShingle Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
Domènech, Laura
Neurosi obsessiva
Microbiologia oral
Excrements
Obsessive-compulsive disorder
Oral microbiology
Feces
title_short Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
title_full Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
title_fullStr Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
title_full_unstemmed Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
title_sort Changes in the stool and oropharyngeal microbiome in obsessive-compulsive disorder
dc.creator.none.fl_str_mv Domènech, Laura
Willis, Jesse
Alemany-Navarro, María
Morey i Ramonell, Marta
Real, Eva
Escaramís Babiano, Geòrgia
Bertolín Triquell, Sara
Sánchez Chinchilla, Daniel
Balcells Comas, Susana
Segalàs Cosi, Cinto
Estivill, Xavier, 1955-
Menchón Magriñá, José Manuel
Gabaldón, Toni
Alonso Ortega, María del Pino
Rabionet Janssen, Raquel
author Domènech, Laura
author_facet Domènech, Laura
Willis, Jesse
Alemany-Navarro, María
Morey i Ramonell, Marta
Real, Eva
Escaramís Babiano, Geòrgia
Bertolín Triquell, Sara
Sánchez Chinchilla, Daniel
Balcells Comas, Susana
Segalàs Cosi, Cinto
Estivill, Xavier, 1955-
Menchón Magriñá, José Manuel
Gabaldón, Toni
Alonso Ortega, María del Pino
Rabionet Janssen, Raquel
author_role author
author2 Willis, Jesse
Alemany-Navarro, María
Morey i Ramonell, Marta
Real, Eva
Escaramís Babiano, Geòrgia
Bertolín Triquell, Sara
Sánchez Chinchilla, Daniel
Balcells Comas, Susana
Segalàs Cosi, Cinto
Estivill, Xavier, 1955-
Menchón Magriñá, José Manuel
Gabaldón, Toni
Alonso Ortega, María del Pino
Rabionet Janssen, Raquel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neurosi obsessiva
Microbiologia oral
Excrements
Obsessive-compulsive disorder
Oral microbiology
Feces
topic Neurosi obsessiva
Microbiologia oral
Excrements
Obsessive-compulsive disorder
Oral microbiology
Feces
description Although the etiology of obsessive-compulsive disorder (OCD) is largely unknown, it is accepted that OCD is a complex disorder. There is a known bi-directional interaction between the gut microbiome and brain activity. Several authors have reported associations between changes in gut microbiota and neuropsychiatric disorders, including depression or autism. Furthermore, a pediatric-onset neuropsychiatric OCD-related syndrome occurs after streptococcal infection, which might indicate that exposure to certain microbes could be involved in OCD susceptibility. However, only one study has investigated the microbiome of OCD patients to date. We performed 16S ribosomal RNA gene-based metagenomic sequencing to analyze the stool and oropharyngeal microbiome composition of 32 OCD cases and 32 age and gender matched controls. We estimated different α- and β-diversity measures and performed LEfSe and Wilcoxon tests to assess differences in bacterial distribution. OCD stool samples showed a trend towards lower bacterial α-diversity, as well as an increase of the relative abundance of Rikenellaceae, particularly of the genus Alistipes, and lower relative abundance of Prevotellaceae, and two genera within the Lachnospiraceae: Agathobacer and Coprococcus. However, we did not observe a different Bacteroidetes to Firmicutes ratio between OCD cases and controls. Analysis of the oropharyngeal microbiome composition showed a lower Fusobacteria to Actinobacteria ratio in OCD cases. In conclusion, we observed an imbalance in the gut and oropharyngeal microbiomes of OCD cases, including, in stool, an increase of bacteria from the Rikenellaceae family, associated with gut inflammation, and a decrease of bacteria from the Coprococcus genus, associated with DOPAC synthesis.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183876
url https://hdl.handle.net/2445/183876
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-022-05480-9
Scientific Reports, 2022
https://doi.org/10.1038/s41598-022-05480-9
dc.rights.none.fl_str_mv cc-by (c) Domènech, Laura et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Domènech, Laura et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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