Epigenetics in Cancer
Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins or cloned animals can have different phenotypes and different susceptibilities to a disease. The concept of epigeneti...
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2008 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/176325 |
| Acceso en línea: | https://hdl.handle.net/2445/176325 |
| Access Level: | acceso abierto |
| Palabra clave: | ADN Epigènesi Expressió gènica Proteïnes supressores de tumors Fisiologia DNA Epigenesis Gene expression Tumor suppressor protein Physiology |
| Sumario: | Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins or cloned animals can have different phenotypes and different susceptibilities to a disease. The concept of epigenetics offers a partial explanation of these phenomena. First introduced by C.H. Waddington in 1939 to name "the causal interactions between genes and their products, which bring the phenotype into being," epigenetics was later defined as heritable changes in gene expression that are not due to any alteration in the DNA sequence. |
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