High circulating SDF-1 and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients

Background: The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4(+) T-cell turnover. Methods: We evaluated the circulating baseline and 48-week f...

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Autores: Yeregui, Elena, Vilades, Consuelo, Domingo, Pere, Ceausu, Andra, Maria Pacheco, Yolanda, Veloso, Sergio, Inciarte, Alexy, Vidal-Gonzalez, Judit, Peraire, Maria, Perpinan, Carles, Falco, Vicentc, Masip, Jenifer, Alba, Veronica, Vargas, Montserrat, Marti, Anna, Reverte, Laia, Mallolas, Josep, Vidal, Francesc, Peraire, Joaquim, Rull, Anna
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/17334
Acceso en línea:https://hdl.handle.net/20.500.13003/17334
Access Level:acceso abierto
Palabra clave:Chemokines
Chemokine receptors
HIV
Poor immune recovery
Polymorphisms variants
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spelling High circulating SDF-1 and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patientsYeregui, ElenaVilades, ConsueloDomingo, PereCeausu, AndraMaria Pacheco, YolandaVeloso, SergioInciarte, AlexyVidal-Gonzalez, JuditPeraire, MariaPerpinan, CarlesFalco, VicentcMasip, JeniferAlba, VeronicaVargas, MontserratMarti, AnnaReverte, LaiaMallolas, JosepVidal, FrancescPeraire, JoaquimRull, AnnaChemokinesChemokine receptorsHIVPoor immune recoveryPolymorphisms variantsBackground: The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4(+) T-cell turnover. Methods: We evaluated the circulating baseline and 48-week follow-up concentrations of SDF-1/CXCL12, fractal-kine/CX3CL1, MCP-1/CCL2, MIP-alpha/CCL3, MIP-beta/CCL4 and RANTES/CCL5, and we estimated their association with CXCL12, CX3CR1, CCR2, CCL5 and CCR5 single nucleotide polymorphisms (SNPs) to investigate multiple chemokine-chemokine receptor signatures associated with immune dysregulation preceding poor immune recovery. Findings: The circulating concentrations and gene expression patterns of SDF-1/CXCL12 (CXCL12 rs1801157) and MCP-1/CCL2 (CCR2 rs1799864_814) were associated with immune recovery status. CCR2 rs1799864_814 and CCR5 rs333_814 (032) determine the baseline plasma RANTES and MIP-alpha concentrations, respectively, in participants with poor immune response. Interpretation: SDF-1/CXCL12 and MCP-1/CCL2 could be considered prognostic markers of immune failure despite suppressive antiretroviral therapy. The strong linkage disequilibrium (LD) between CCR2 rs1799864_814 and CCR5 rs1800024 indicated that the alleles of each gene are inherited together more often than would be expected by chance.Elsevier20202020-12-0120202020-12-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/17334reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/173342026-06-22T12:44:07Z
dc.title.none.fl_str_mv High circulating SDF-1 and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients
title High circulating SDF-1 and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients
spellingShingle High circulating SDF-1 and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients
Yeregui, Elena
Chemokines
Chemokine receptors
HIV
Poor immune recovery
Polymorphisms variants
title_short High circulating SDF-1 and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients
title_full High circulating SDF-1 and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients
title_fullStr High circulating SDF-1 and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients
title_full_unstemmed High circulating SDF-1 and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients
title_sort High circulating SDF-1 and MCP-1 levels and genetic variations in CXCL12, CCL2 and CCR5: Prognostic signature of immune recovery status in treated HIV-positive patients
dc.creator.none.fl_str_mv Yeregui, Elena
Vilades, Consuelo
Domingo, Pere
Ceausu, Andra
Maria Pacheco, Yolanda
Veloso, Sergio
Inciarte, Alexy
Vidal-Gonzalez, Judit
Peraire, Maria
Perpinan, Carles
Falco, Vicentc
Masip, Jenifer
Alba, Veronica
Vargas, Montserrat
Marti, Anna
Reverte, Laia
Mallolas, Josep
Vidal, Francesc
Peraire, Joaquim
Rull, Anna
author Yeregui, Elena
author_facet Yeregui, Elena
Vilades, Consuelo
Domingo, Pere
Ceausu, Andra
Maria Pacheco, Yolanda
Veloso, Sergio
Inciarte, Alexy
Vidal-Gonzalez, Judit
Peraire, Maria
Perpinan, Carles
Falco, Vicentc
Masip, Jenifer
Alba, Veronica
Vargas, Montserrat
Marti, Anna
Reverte, Laia
Mallolas, Josep
Vidal, Francesc
Peraire, Joaquim
Rull, Anna
author_role author
author2 Vilades, Consuelo
Domingo, Pere
Ceausu, Andra
Maria Pacheco, Yolanda
Veloso, Sergio
Inciarte, Alexy
Vidal-Gonzalez, Judit
Peraire, Maria
Perpinan, Carles
Falco, Vicentc
Masip, Jenifer
Alba, Veronica
Vargas, Montserrat
Marti, Anna
Reverte, Laia
Mallolas, Josep
Vidal, Francesc
Peraire, Joaquim
Rull, Anna
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Chemokines
Chemokine receptors
HIV
Poor immune recovery
Polymorphisms variants
topic Chemokines
Chemokine receptors
HIV
Poor immune recovery
Polymorphisms variants
description Background: The underlying mechanisms of incomplete immune reconstitution in treated HIV-positive patients are very complex and may be multifactorial, but perturbation of chemokine secretion could play a key role in CD4(+) T-cell turnover. Methods: We evaluated the circulating baseline and 48-week follow-up concentrations of SDF-1/CXCL12, fractal-kine/CX3CL1, MCP-1/CCL2, MIP-alpha/CCL3, MIP-beta/CCL4 and RANTES/CCL5, and we estimated their association with CXCL12, CX3CR1, CCR2, CCL5 and CCR5 single nucleotide polymorphisms (SNPs) to investigate multiple chemokine-chemokine receptor signatures associated with immune dysregulation preceding poor immune recovery. Findings: The circulating concentrations and gene expression patterns of SDF-1/CXCL12 (CXCL12 rs1801157) and MCP-1/CCL2 (CCR2 rs1799864_814) were associated with immune recovery status. CCR2 rs1799864_814 and CCR5 rs333_814 (032) determine the baseline plasma RANTES and MIP-alpha concentrations, respectively, in participants with poor immune response. Interpretation: SDF-1/CXCL12 and MCP-1/CCL2 could be considered prognostic markers of immune failure despite suppressive antiretroviral therapy. The strong linkage disequilibrium (LD) between CCR2 rs1799864_814 and CCR5 rs1800024 indicated that the alleles of each gene are inherited together more often than would be expected by chance.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-12-01
2020
2020-12-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/17334
url https://hdl.handle.net/20.500.13003/17334
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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