Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016

Background: Streptococcus pneumoniae is an important pathogen in chronic obstructive pulmonary disease (COPD). We aimed at showing the recent changes in the epidemiology of pneumococcal diseases in patients with COPD, especially after the introduction of the 13-valent pneumococcal conjugate vaccine...

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Autores: Shoji, Hisashi, Vázquez Sánchez, Daniel Antonio, González Díaz, Aida, Cubero, Meritxell, Tubau, Fe, Santos Pérez, Salud, García Somoza, Dolors, Liñares Louzao, Josefina, Yuste, José Enrique, Martí Martí, Sara, Ardanuy Tisaire, María Carmen
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172759
Acesso em linha:https://hdl.handle.net/2445/172759
Access Level:acceso abierto
Palavra-chave:Malalties pulmonars obstructives cròniques
Pneumococs
Vacunes
Hospitals
Chronic obstructive pulmonary diseases
Streptococcus pneumonia
Vaccines
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spelling Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016Shoji, HisashiVázquez Sánchez, Daniel AntonioGonzález Díaz, AidaCubero, MeritxellTubau, FeSantos Pérez, SaludGarcía Somoza, DolorsLiñares Louzao, JosefinaYuste, José EnriqueMartí Martí, SaraArdanuy Tisaire, María CarmenMalalties pulmonars obstructives cròniquesPneumococsVacunesHospitalsChronic obstructive pulmonary diseasesStreptococcus pneumoniaVaccinesHospitalsBackground: Streptococcus pneumoniae is an important pathogen in chronic obstructive pulmonary disease (COPD). We aimed at showing the recent changes in the epidemiology of pneumococcal diseases in patients with COPD, especially after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Methods: From 2013 to 2016, strains causing invasive pneumococcal disease (IPD), non-bacteremic pneumococcal pneumonia (non-BPP), and acute exacerbation of COPD (AE-COPD) were prospectively included. Antimicrobial susceptibility testing, serotyping, and genotyping were analyzed. Results: We collected 345 pneumococci from 286 COPD patients (57 IPD, 78 non-BPP, and 210 AE-COPD). The most frequent serotypes were serotypes 3 (14.0%), 8 (14.0%), and 12F (8.8%) in IPD; serotypes 3 (16.7%), 11A (9%), 9L/N (7.7%), and 23A (7.7%) in non-BPP; and serotypes 11A (11%), nontypeable (11%), and 6C (10%) in AE-COPD. Resistance rates were highest among AE-COPD strains. Penicillin resistance was associated with serotypes 11A (CC156) and 19A (CC320 and CC230). Compared with previous studies, fluoroquinolone resistance in AE-COPD increased (9.5%), PCV13 serotypes decreased (31.6%, 26.9%, and 16.7% for IPD, non-BPP, and AE-COPD, respectively), and serotype 11A-CC156 in AE-COPD and serotype 8 in IPD increased. Conclusion: The epidemiology of pneumococcal disease in COPD changed after the introduction of PCV13 in children. Increases in the highly invasive serotype 8 among patients with IPD and in serotype 11A-CC156 among patients with AE-COPD could compromise the ability of current PCVs to prevent diseases. Vaccines with a greater coverage could improve the benefits of adult vaccination.Dove Medical Press2020202020182020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/172759Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.2147/IDR.S165093Infection and Drug Resistance, 2018, vol. 11, p. 1387-1400https://doi.org/10.2147/IDR.S165093cc-by-nc (c) Shoji, Hisashi et al., 2018http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1727592026-05-29T05:05:01Z
dc.title.none.fl_str_mv Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016
title Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016
spellingShingle Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016
Shoji, Hisashi
Malalties pulmonars obstructives cròniques
Pneumococs
Vacunes
Hospitals
Chronic obstructive pulmonary diseases
Streptococcus pneumonia
Vaccines
Hospitals
title_short Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016
title_full Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016
title_fullStr Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016
title_full_unstemmed Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016
title_sort Overview of pneumococcal serotypes and genotypes causing diseases in patients with chronic obstructive pulmonary disease in a Spanish hospital between 2013 and 2016
dc.creator.none.fl_str_mv Shoji, Hisashi
Vázquez Sánchez, Daniel Antonio
González Díaz, Aida
Cubero, Meritxell
Tubau, Fe
Santos Pérez, Salud
García Somoza, Dolors
Liñares Louzao, Josefina
Yuste, José Enrique
Martí Martí, Sara
Ardanuy Tisaire, María Carmen
author Shoji, Hisashi
author_facet Shoji, Hisashi
Vázquez Sánchez, Daniel Antonio
González Díaz, Aida
Cubero, Meritxell
Tubau, Fe
Santos Pérez, Salud
García Somoza, Dolors
Liñares Louzao, Josefina
Yuste, José Enrique
Martí Martí, Sara
Ardanuy Tisaire, María Carmen
author_role author
author2 Vázquez Sánchez, Daniel Antonio
González Díaz, Aida
Cubero, Meritxell
Tubau, Fe
Santos Pérez, Salud
García Somoza, Dolors
Liñares Louzao, Josefina
Yuste, José Enrique
Martí Martí, Sara
Ardanuy Tisaire, María Carmen
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties pulmonars obstructives cròniques
Pneumococs
Vacunes
Hospitals
Chronic obstructive pulmonary diseases
Streptococcus pneumonia
Vaccines
Hospitals
topic Malalties pulmonars obstructives cròniques
Pneumococs
Vacunes
Hospitals
Chronic obstructive pulmonary diseases
Streptococcus pneumonia
Vaccines
Hospitals
description Background: Streptococcus pneumoniae is an important pathogen in chronic obstructive pulmonary disease (COPD). We aimed at showing the recent changes in the epidemiology of pneumococcal diseases in patients with COPD, especially after the introduction of the 13-valent pneumococcal conjugate vaccine (PCV13). Methods: From 2013 to 2016, strains causing invasive pneumococcal disease (IPD), non-bacteremic pneumococcal pneumonia (non-BPP), and acute exacerbation of COPD (AE-COPD) were prospectively included. Antimicrobial susceptibility testing, serotyping, and genotyping were analyzed. Results: We collected 345 pneumococci from 286 COPD patients (57 IPD, 78 non-BPP, and 210 AE-COPD). The most frequent serotypes were serotypes 3 (14.0%), 8 (14.0%), and 12F (8.8%) in IPD; serotypes 3 (16.7%), 11A (9%), 9L/N (7.7%), and 23A (7.7%) in non-BPP; and serotypes 11A (11%), nontypeable (11%), and 6C (10%) in AE-COPD. Resistance rates were highest among AE-COPD strains. Penicillin resistance was associated with serotypes 11A (CC156) and 19A (CC320 and CC230). Compared with previous studies, fluoroquinolone resistance in AE-COPD increased (9.5%), PCV13 serotypes decreased (31.6%, 26.9%, and 16.7% for IPD, non-BPP, and AE-COPD, respectively), and serotype 11A-CC156 in AE-COPD and serotype 8 in IPD increased. Conclusion: The epidemiology of pneumococcal disease in COPD changed after the introduction of PCV13 in children. Increases in the highly invasive serotype 8 among patients with IPD and in serotype 11A-CC156 among patients with AE-COPD could compromise the ability of current PCVs to prevent diseases. Vaccines with a greater coverage could improve the benefits of adult vaccination.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172759
url https://hdl.handle.net/2445/172759
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2147/IDR.S165093
Infection and Drug Resistance, 2018, vol. 11, p. 1387-1400
https://doi.org/10.2147/IDR.S165093
dc.rights.none.fl_str_mv cc-by-nc (c) Shoji, Hisashi et al., 2018
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Shoji, Hisashi et al., 2018
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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