High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.

We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011–June 2014 that had optimize...

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Autores: San Juan Garrido, Rafael, Viedma, Esther, Chaves Sánchez, Fernando, Lalueza, Antonio, Lalueza Blanco, Antonio, Forrtún, Jesús, Loza, Elena, Pujol, Miquel, Ardanuy, Carmen, Morales, Isabel, de Cueto, Marina, Resino-Foz, Elena, Morales-Cartagena, Alejandra, Rico, Alicia, Romero, María, Orellana Miguel, María Ángeles, López Medrano, Francisco, Fernández Ruiz, Mario, Aguado García, José María
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/117524
Acceso en línea:https://hdl.handle.net/20.500.14352/117524
Access Level:acceso abierto
Palabra clave:Enfermedades infecciosas
Farmacología (Medicina)
3205.05 Enfermedades Infecciosas
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oai_identifier_str oai:docta.ucm.es:20.500.14352/117524
network_acronym_str ES
network_name_str España
repository_id_str
spelling High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.San Juan Garrido, RafaelViedma, EstherChaves Sánchez, FernandoLalueza, AntonioLalueza Blanco, AntonioForrtún, JesúsLoza, ElenaPujol, MiquelArdanuy, CarmenMorales, Isabelde Cueto, MarinaResino-Foz, ElenaMorales-Cartagena, AlejandraRico, AliciaRomero, MaríaOrellana Miguel, María ÁngelesLópez Medrano, FranciscoFernández Ruiz, MarioAguado García, José MaríaEnfermedades infecciosasFarmacología (Medicina)3205.05 Enfermedades InfecciosasWe investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011–June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 μg/mL and 0.5 μg/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2–5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1–5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.Centers for Disease Control and PreventionUniversidad Complutense de Madrid20162016-06-0120162016-06-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/117524reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengEC PS11 01229EC REIPI RD12 0015open accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1175242026-06-02T12:44:21Z
dc.title.none.fl_str_mv High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
title High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
spellingShingle High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
San Juan Garrido, Rafael
Enfermedades infecciosas
Farmacología (Medicina)
3205.05 Enfermedades Infecciosas
title_short High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
title_full High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
title_fullStr High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
title_full_unstemmed High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
title_sort High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
dc.creator.none.fl_str_mv San Juan Garrido, Rafael
Viedma, Esther
Chaves Sánchez, Fernando
Lalueza, Antonio
Lalueza Blanco, Antonio
Forrtún, Jesús
Loza, Elena
Pujol, Miquel
Ardanuy, Carmen
Morales, Isabel
de Cueto, Marina
Resino-Foz, Elena
Morales-Cartagena, Alejandra
Rico, Alicia
Romero, María
Orellana Miguel, María Ángeles
López Medrano, Francisco
Fernández Ruiz, Mario
Aguado García, José María
author San Juan Garrido, Rafael
author_facet San Juan Garrido, Rafael
Viedma, Esther
Chaves Sánchez, Fernando
Lalueza, Antonio
Lalueza Blanco, Antonio
Forrtún, Jesús
Loza, Elena
Pujol, Miquel
Ardanuy, Carmen
Morales, Isabel
de Cueto, Marina
Resino-Foz, Elena
Morales-Cartagena, Alejandra
Rico, Alicia
Romero, María
Orellana Miguel, María Ángeles
López Medrano, Francisco
Fernández Ruiz, Mario
Aguado García, José María
author_role author
author2 Viedma, Esther
Chaves Sánchez, Fernando
Lalueza, Antonio
Lalueza Blanco, Antonio
Forrtún, Jesús
Loza, Elena
Pujol, Miquel
Ardanuy, Carmen
Morales, Isabel
de Cueto, Marina
Resino-Foz, Elena
Morales-Cartagena, Alejandra
Rico, Alicia
Romero, María
Orellana Miguel, María Ángeles
López Medrano, Francisco
Fernández Ruiz, Mario
Aguado García, José María
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Enfermedades infecciosas
Farmacología (Medicina)
3205.05 Enfermedades Infecciosas
topic Enfermedades infecciosas
Farmacología (Medicina)
3205.05 Enfermedades Infecciosas
description We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011–June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 μg/mL and 0.5 μg/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2–5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1–5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-06-01
2016
2016-06-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/117524
url https://hdl.handle.net/20.500.14352/117524
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv EC PS11 01229
EC REIPI RD12 0015
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Centers for Disease Control and Prevention
publisher.none.fl_str_mv Centers for Disease Control and Prevention
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407771878752256
score 15,81155

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