Antioxidant Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Films Loaded with Resveratrol Solubilized in Deep Eutectic Solvents

The present study explores the remarkable capabilities of deep eutectic solvents (DES) for enhancing the antioxidant properties of films containing the natural antioxidant resveratrol (Res). A key achievement of this work is the unprecedented solubility of resveratrol400 mg/mLin a highly effective...

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Detalles Bibliográficos
Autores: Basar, Ahmet O, Prieto López, Cristina, Bardakou, Evangelia, Cabedo, Luis, Lagarón Cabello, José M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/401409
Acceso en línea:http://hdl.handle.net/10261/401409
Access Level:acceso abierto
Palabra clave:DES
PHBV
Active packaging
Antioxidants
Electrospinning
Resveratrol
resveratrol
antioxidants
active packaging
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repository_id_str
spelling Antioxidant Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Films Loaded with Resveratrol Solubilized in Deep Eutectic SolventsBasar, Ahmet OPrieto López, CristinaBardakou, EvangeliaCabedo, LuisLagarón Cabello, José M.DESPHBVActive packagingAntioxidantsElectrospinningResveratrolresveratrolantioxidantsactive packagingThe present study explores the remarkable capabilities of deep eutectic solvents (DES) for enhancing the antioxidant properties of films containing the natural antioxidant resveratrol (Res). A key achievement of this work is the unprecedented solubility of resveratrol400 mg/mLin a highly effective DES composed of choline chloride (ChCl) and ethylene glycol (EG), representing a significant enhancement over previously reported values. For the active and sustainable packaging development purposes, this was coupled with the creation of continuous and nonporous electrospun poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) biopaper material through electrospinning and subsequent thermal annealing processes, featuring enhanced antioxidant properties. Remarkably, a second achievement of this paper is that electrospun biopapers containing DES-solubilized Res exhibited a 30% improvement in antioxidant activity and material efficiency compared to those containing the same amount of nonsolubilized resveratrol within the polymer. Additionally, characterization was made via wide-angle X-ray diffraction, optical properties, mechanical and barrier testing, demonstrating that the studied DES not only optimized the functional attributes of PHBV biopapers but also maintained their structural integrity and mechanical and barrier performance. Therefore, this study highlights the potential of DES as a potent tool for improving the effectiveness of poorly soluble natural antioxidants, paving the way for the development of innovative solutions in active and sustainable packaging.A.O. Basar wants to thank the Generalitat Valencia (GVA) for his Grisolía Fellowship (GRISOLIA/2020/19). The authors would like to acknowledge the Polymer Technology joint unit UJI-IATA-CSIC, the CSIC-PTI SusPlast, and the Spanish government MCIN/AEI to the Center of Excellence Accreditation Severo Ochoa (CEX2021-001189-S/MCIN/AEI/10.13039/501100011033).With funding from the Spanish government through the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2021-001189-S)Peer reviewedACS PublicationsGeneralitat ValencianaMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)CSIC - Plataforma Temática Interdisciplinar del CSIC plásticos Sostenibles (PTI SusPlast)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/401409reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001189-SACS applied polymer materialsThe underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1021/acsapm.5c01101https://doi.org/10.1021/acsapm.5c01101Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4014092026-05-22T06:33:51Z
dc.title.none.fl_str_mv Antioxidant Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Films Loaded with Resveratrol Solubilized in Deep Eutectic Solvents
title Antioxidant Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Films Loaded with Resveratrol Solubilized in Deep Eutectic Solvents
spellingShingle Antioxidant Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Films Loaded with Resveratrol Solubilized in Deep Eutectic Solvents
Basar, Ahmet O
DES
PHBV
Active packaging
Antioxidants
Electrospinning
Resveratrol
resveratrol
antioxidants
active packaging
title_short Antioxidant Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Films Loaded with Resveratrol Solubilized in Deep Eutectic Solvents
title_full Antioxidant Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Films Loaded with Resveratrol Solubilized in Deep Eutectic Solvents
title_fullStr Antioxidant Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Films Loaded with Resveratrol Solubilized in Deep Eutectic Solvents
title_full_unstemmed Antioxidant Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Films Loaded with Resveratrol Solubilized in Deep Eutectic Solvents
title_sort Antioxidant Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) Films Loaded with Resveratrol Solubilized in Deep Eutectic Solvents
dc.creator.none.fl_str_mv Basar, Ahmet O
Prieto López, Cristina
Bardakou, Evangelia
Cabedo, Luis
Lagarón Cabello, José M.
author Basar, Ahmet O
author_facet Basar, Ahmet O
Prieto López, Cristina
Bardakou, Evangelia
Cabedo, Luis
Lagarón Cabello, José M.
author_role author
author2 Prieto López, Cristina
Bardakou, Evangelia
Cabedo, Luis
Lagarón Cabello, José M.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Generalitat Valenciana
Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
CSIC - Plataforma Temática Interdisciplinar del CSIC plásticos Sostenibles (PTI SusPlast)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv DES
PHBV
Active packaging
Antioxidants
Electrospinning
Resveratrol
resveratrol
antioxidants
active packaging
topic DES
PHBV
Active packaging
Antioxidants
Electrospinning
Resveratrol
resveratrol
antioxidants
active packaging
description The present study explores the remarkable capabilities of deep eutectic solvents (DES) for enhancing the antioxidant properties of films containing the natural antioxidant resveratrol (Res). A key achievement of this work is the unprecedented solubility of resveratrol400 mg/mLin a highly effective DES composed of choline chloride (ChCl) and ethylene glycol (EG), representing a significant enhancement over previously reported values. For the active and sustainable packaging development purposes, this was coupled with the creation of continuous and nonporous electrospun poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) biopaper material through electrospinning and subsequent thermal annealing processes, featuring enhanced antioxidant properties. Remarkably, a second achievement of this paper is that electrospun biopapers containing DES-solubilized Res exhibited a 30% improvement in antioxidant activity and material efficiency compared to those containing the same amount of nonsolubilized resveratrol within the polymer. Additionally, characterization was made via wide-angle X-ray diffraction, optical properties, mechanical and barrier testing, demonstrating that the studied DES not only optimized the functional attributes of PHBV biopapers but also maintained their structural integrity and mechanical and barrier performance. Therefore, this study highlights the potential of DES as a potent tool for improving the effectiveness of poorly soluble natural antioxidants, paving the way for the development of innovative solutions in active and sustainable packaging.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/401409
url http://hdl.handle.net/10261/401409
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/CEX2021-001189-S
ACS applied polymer materials
The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.1021/acsapm.5c01101
https://doi.org/10.1021/acsapm.5c01101
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ACS Publications
publisher.none.fl_str_mv ACS Publications
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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