A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.

Escala-Garcia, Maria; Abraham, Jean; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Ashworth, Alan; Auer, Paul L; Auvinen, Päivi; Beckmann, Matthias W; Beesley, Jonathan; Behrens, Sabine; Benitez, Javier; Bermisheva, Marina; Blomqvist, Carl; Blot, William; Bogdanova, Natalia V; Bojesen, Stig E; Bolla, Manjeet K; Børresen-Dale, Anne-Lise; Brauch, Hiltrud; Brenner, Hermann; Brucker, Sara Y; Burwinkel, Barbara; Caldas, Carlos; Canzian, Federico; Chang-Claude, Jenny; Chanock, Stephen J; Chin, Suet-Feung; Clarke, Christine L; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Daly, Mary B; Dennis, Joe; Devilee, Peter; Dunn, Janet A; Dunning, Alison M; Dwek, Miriam; Earl, Helena M; Eccles, Diana M; Eliassen, A Heather; Ellberg, Carolina; Evans, D Gareth; Fasching, Peter A; Figueroa, Jonine; Flyger, Henrik; Gago-Dominguez, Manuela; Gapstur, Susan M; García-Closas, Montserrat; García-Sáenz, José A; Gaudet, Mia M; George, Angela; Giles, Graham G; Goldgar, David E; González-Neira, Anna; Grip, Mervi; Guénel, Pascal; Guo, Qi; Haiman, Christopher A; Håkansson, Niclas; Hamann, Ute; Harrington, Patricia A; Hiller, Louise; Hooning, Maartje J; Hopper, John L; Howell, Anthony; Huang, Chiun-Sheng; Huang, Guanmengqian; Hunter, David J; Jakubowska, Anna; John, Esther M; Kaaks, Rudolf; Kapoor, Pooja Middha; Keeman, Renske; Kitahara, Cari M; Kraft, Peter; Lambrechts, Diether; Le Marchand, Loic; Lejbkowicz, Flavio; Lindblom, Annika; Lubiński, Jan; Mannermaa, Arto; Manoochehri, Mehdi; Manoukian, Siranoush; Margolin, Sara; Martinez, Maria Elena; Maurer, Tabea; Mavroudis, Dimitrios; Meindl, Alfons; Milne, Roger L; Mulligan, Anna Marie; Neuhausen, Susan L; Nevanlinna, Heli; Newman, William G; Olshan, Andrew F; Olson, Janet E; Olsson, Håkan; Orr, Nick; Peterlongo, Paolo; Petridis, Christos; Prentice, Ross L; Presneau, Nadege; Punie, Kevin; Ramachandran, Dhanya; Rennert, Gad; Romero, Atocha; Sachchithananthan, Mythily; Saloustros, Emmanouil; Sawyer, Elinor J; Schmutzler, Rita K; Schwentner, Lukas; Scott, Christopher; Simard, Jacques; Sohn, Christof; Southey, Melissa C; Swerdlow, Anthony J; Tamimi, Rulla M; Tapper, William J; Teixeira, Manuel R; Terry, Mary Beth; Thorne, Heather; Tollenaar, Rob A E M; Tomlinson, Ian; Troester, Melissa A; Truong, Thérèse; Turnbull, Clare; Vachon, Celine M; van der Kolk, Lizet E; Wang, Qin; Winqvist, Robert; Wolk, Alicja; Yang, Xiaohong R; Ziogas, Argyrios; Pharoah, Paul D P; Hall, Per; Wessels, Lodewyk F A; Chenevix-Trench, Georgia; Bader, Gary D; Dörk, Thilo; Easton, Douglas F; Canisius, Sander; Schmidt, Marjanka K; Gonzalez Neira, Anna; Andrulis, Irene L.; Auer, Paul L.; Beckmann, Matthias W.; Bogdanova, Natalia V.; Bojesen, Stig E.; Bolla, Manjeet K.; Brucker, Sara Y.; Chanock, Stephen J.; Clarke, Christine L.; Couch, Fergus J.; Cross, Simon S.; Daly, Mary B.; Dunn, Janet A.; Dunning, Alison M.; Earl, Helena M.; Eccles, Diana M.; Eliassen, A. Heather; Evans, D. Gareth; Fasching, Peter A.; Gapstur, Susan M.; García-Sáenz, José A.; Gaudet, Mia M.; Giles, Graham G.; Goldgar, David E.; Haiman, Christopher A.; Harrington, Patricia A.; Hooning, Maartje J.; Hopper, John L.; Hunter, David J.; John, Esther M.; Kitahara, Cari M.; Koppert, Linetta B; Kristensen, Vessela N; Milne, Roger L.; Neuhausen, Susan L.; Newman, William G.; Olshan, Andrew F.; Olson, Janet E.; Prentice, Ross L.; Sawyer, Elinor J.; Schmutzler, Rita K.; Southey, Melissa C.; Swerdlow, Anthony J.; Tamimi, Rulla M.; Tapper, William J.; Tollenaar, Rob A. E. M.; Troester, Melissa A.; Vachon, Celine M.; van der Kolk, Lizet E.; Yang, Xiaohong R.; Pharoah, Paul D. P.; Wessels, Lodewyk F. A.; Bader, Gary D.; Easton, Douglas F.; Schmidt, Marjanka K.

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.

Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based...

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Detalhes bibliográficos
Autores:	Escala-Garcia, Maria, Abraham, Jean, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Ashworth, Alan, Auer, Paul L, Auvinen, Päivi, Beckmann, Matthias W, Beesley, Jonathan, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Blot, William, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Børresen-Dale, Anne-Lise, Brauch, Hiltrud, Brenner, Hermann, Brucker, Sara Y, Burwinkel, Barbara, Caldas, Carlos, Canzian, Federico, Chang-Claude, Jenny, Chanock, Stephen J, Chin, Suet-Feung, Clarke, Christine L, Couch, Fergus J, Cox, Angela, Cross, Simon S, Czene, Kamila, Daly, Mary B, Dennis, Joe, Devilee, Peter, Dunn, Janet A, Dunning, Alison M, Dwek, Miriam, Earl, Helena M, Eccles, Diana M, Eliassen, A Heather, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Figueroa, Jonine, Flyger, Henrik, Gago-Dominguez, Manuela, Gapstur, Susan M, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, George, Angela, Giles, Graham G, Goldgar, David E, González-Neira, Anna, Grip, Mervi, Guénel, Pascal, Guo, Qi, Haiman, Christopher A, Håkansson, Niclas, Hamann, Ute, Harrington, Patricia A, Hiller, Louise, Hooning, Maartje J, Hopper, John L, Howell, Anthony, Huang, Chiun-Sheng, Huang, Guanmengqian, Hunter, David J, Jakubowska, Anna, John, Esther M, Kaaks, Rudolf, Kapoor, Pooja Middha, Keeman, Renske, Kitahara, Cari M, Kraft, Peter, Lambrechts, Diether, Le Marchand, Loic, Lejbkowicz, Flavio, Lindblom, Annika, Lubiński, Jan, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Martinez, Maria Elena, Maurer, Tabea, Mavroudis, Dimitrios, Meindl, Alfons, Milne, Roger L, Mulligan, Anna Marie, Neuhausen, Susan L, Nevanlinna, Heli, Newman, William G, Olshan, Andrew F, Olson, Janet E, Olsson, Håkan, Orr, Nick, Peterlongo, Paolo, Petridis, Christos, Prentice, Ross L, Presneau, Nadege, Punie, Kevin, Ramachandran, Dhanya, Rennert, Gad, Romero, Atocha, Sachchithananthan, Mythily, Saloustros, Emmanouil, Sawyer, Elinor J, Schmutzler, Rita K, Schwentner, Lukas, Scott, Christopher, Simard, Jacques, Sohn, Christof, Southey, Melissa C, Swerdlow, Anthony J, Tamimi, Rulla M, Tapper, William J, Teixeira, Manuel R, Terry, Mary Beth, Thorne, Heather, Tollenaar, Rob A E M, Tomlinson, Ian, Troester, Melissa A, Truong, Thérèse, Turnbull, Clare, Vachon, Celine M, van der Kolk, Lizet E, Wang, Qin, Winqvist, Robert, Wolk, Alicja, Yang, Xiaohong R, Ziogas, Argyrios, Pharoah, Paul D P, Hall, Per, Wessels, Lodewyk F A, Chenevix-Trench, Georgia, Bader, Gary D, Dörk, Thilo, Easton, Douglas F, Canisius, Sander, Schmidt, Marjanka K, Gonzalez Neira, Anna, Andrulis, Irene L., Auer, Paul L., Beckmann, Matthias W., Bogdanova, Natalia V., Bojesen, Stig E., Bolla, Manjeet K., Brucker, Sara Y., Chanock, Stephen J., Clarke, Christine L., Couch, Fergus J., Cross, Simon S., Daly, Mary B., Dunn, Janet A., Dunning, Alison M., Earl, Helena M., Eccles, Diana M., Eliassen, A. Heather, Evans, D. Gareth, Fasching, Peter A., Gapstur, Susan M., García-Sáenz, José A., Gaudet, Mia M., Giles, Graham G., Goldgar, David E., Haiman, Christopher A., Harrington, Patricia A., Hooning, Maartje J., Hopper, John L., Hunter, David J., John, Esther M., Kitahara, Cari M., Koppert, Linetta B, Kristensen, Vessela N, Milne, Roger L., Neuhausen, Susan L., Newman, William G., Olshan, Andrew F., Olson, Janet E., Prentice, Ross L., Sawyer, Elinor J., Schmutzler, Rita K., Southey, Melissa C., Swerdlow, Anthony J., Tamimi, Rulla M., Tapper, William J., Tollenaar, Rob A. E. M., Troester, Melissa A., Vachon, Celine M., van der Kolk, Lizet E., Yang, Xiaohong R., Pharoah, Paul D. P., Wessels, Lodewyk F. A., Bader, Gary D., Easton, Douglas F., Schmidt, Marjanka K.
Formato:	artículo
Fecha de publicación:	2020
País:	España
Recursos:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/12181
Acesso em linha:	http://hdl.handle.net/20.500.12105/12181
Access Level:	acceso abierto
Palavra-chave:	Genetic Variation Genome-Wide Association Study Germ Cells Apoptosis Breast Neoplasms Circadian Clocks Computational Biology Female GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits, Gq-G11 Gene Regulatory Networks Genotype Humans Prognosis Receptors, Estrogen Signal Transduction

id	ES_4e90fa852f8244b157b13a8ffbbcf0ae
oai_identifier_str	oai:repisalud.isciii.es:20.500.12105/12181
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
title	A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
spellingShingle	A network analysis to identify mediators of germline-driven differences in breast cancer prognosis. Escala-Garcia, Maria Genetic Variation Genome-Wide Association Study Germ Cells Apoptosis Breast Neoplasms Circadian Clocks Computational Biology Female GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits, Gq-G11 Gene Regulatory Networks Genotype Humans Prognosis Receptors, Estrogen Signal Transduction
title_short	A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
title_full	A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
title_fullStr	A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
title_full_unstemmed	A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
title_sort	A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
dc.creator.none.fl_str_mv	Escala-Garcia, Maria Abraham, Jean Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Ashworth, Alan Auer, Paul L Auvinen, Päivi Beckmann, Matthias W Beesley, Jonathan Behrens, Sabine Benitez, Javier Bermisheva, Marina Blomqvist, Carl Blot, William Bogdanova, Natalia V Bojesen, Stig E Bolla, Manjeet K Børresen-Dale, Anne-Lise Brauch, Hiltrud Brenner, Hermann Brucker, Sara Y Burwinkel, Barbara Caldas, Carlos Canzian, Federico Chang-Claude, Jenny Chanock, Stephen J Chin, Suet-Feung Clarke, Christine L Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Daly, Mary B Dennis, Joe Devilee, Peter Dunn, Janet A Dunning, Alison M Dwek, Miriam Earl, Helena M Eccles, Diana M Eliassen, A Heather Ellberg, Carolina Evans, D Gareth Fasching, Peter A Figueroa, Jonine Flyger, Henrik Gago-Dominguez, Manuela Gapstur, Susan M García-Closas, Montserrat García-Sáenz, José A Gaudet, Mia M George, Angela Giles, Graham G Goldgar, David E González-Neira, Anna Grip, Mervi Guénel, Pascal Guo, Qi Haiman, Christopher A Håkansson, Niclas Hamann, Ute Harrington, Patricia A Hiller, Louise Hooning, Maartje J Hopper, John L Howell, Anthony Huang, Chiun-Sheng Huang, Guanmengqian Hunter, David J Jakubowska, Anna John, Esther M Kaaks, Rudolf Kapoor, Pooja Middha Keeman, Renske Kitahara, Cari M Kraft, Peter Lambrechts, Diether Le Marchand, Loic Lejbkowicz, Flavio Lindblom, Annika Lubiński, Jan Mannermaa, Arto Manoochehri, Mehdi Manoukian, Siranoush Margolin, Sara Martinez, Maria Elena Maurer, Tabea Mavroudis, Dimitrios Meindl, Alfons Milne, Roger L Mulligan, Anna Marie Neuhausen, Susan L Nevanlinna, Heli Newman, William G Olshan, Andrew F Olson, Janet E Olsson, Håkan Orr, Nick Peterlongo, Paolo Petridis, Christos Prentice, Ross L Presneau, Nadege Punie, Kevin Ramachandran, Dhanya Rennert, Gad Romero, Atocha Sachchithananthan, Mythily Saloustros, Emmanouil Sawyer, Elinor J Schmutzler, Rita K Schwentner, Lukas Scott, Christopher Simard, Jacques Sohn, Christof Southey, Melissa C Swerdlow, Anthony J Tamimi, Rulla M Tapper, William J Teixeira, Manuel R Terry, Mary Beth Thorne, Heather Tollenaar, Rob A E M Tomlinson, Ian Troester, Melissa A Truong, Thérèse Turnbull, Clare Vachon, Celine M van der Kolk, Lizet E Wang, Qin Winqvist, Robert Wolk, Alicja Yang, Xiaohong R Ziogas, Argyrios Pharoah, Paul D P Hall, Per Wessels, Lodewyk F A Chenevix-Trench, Georgia Bader, Gary D Dörk, Thilo Easton, Douglas F Canisius, Sander Schmidt, Marjanka K Gonzalez Neira, Anna Andrulis, Irene L. Auer, Paul L. Beckmann, Matthias W. Bogdanova, Natalia V. Bojesen, Stig E. Bolla, Manjeet K. Brucker, Sara Y. Chanock, Stephen J. Clarke, Christine L. Couch, Fergus J. Cross, Simon S. Daly, Mary B. Dunn, Janet A. Dunning, Alison M. Earl, Helena M. Eccles, Diana M. Eliassen, A. Heather Evans, D. Gareth Fasching, Peter A. Gapstur, Susan M. García-Sáenz, José A. Gaudet, Mia M. Giles, Graham G. Goldgar, David E. Haiman, Christopher A. Harrington, Patricia A. Hooning, Maartje J. Hopper, John L. Hunter, David J. John, Esther M. Kitahara, Cari M. Koppert, Linetta B Kristensen, Vessela N Milne, Roger L. Neuhausen, Susan L. Newman, William G. Olshan, Andrew F. Olson, Janet E. Prentice, Ross L. Sawyer, Elinor J. Schmutzler, Rita K. Southey, Melissa C. Swerdlow, Anthony J. Tamimi, Rulla M. Tapper, William J. Tollenaar, Rob A. E. M. Troester, Melissa A. Vachon, Celine M. van der Kolk, Lizet E. Yang, Xiaohong R. Pharoah, Paul D. P. Wessels, Lodewyk F. A. Bader, Gary D. Easton, Douglas F. Schmidt, Marjanka K.
author	Escala-Garcia, Maria
author_facet	Escala-Garcia, Maria Abraham, Jean Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Ashworth, Alan Auer, Paul L Auvinen, Päivi Beckmann, Matthias W Beesley, Jonathan Behrens, Sabine Benitez, Javier Bermisheva, Marina Blomqvist, Carl Blot, William Bogdanova, Natalia V Bojesen, Stig E Bolla, Manjeet K Børresen-Dale, Anne-Lise Brauch, Hiltrud Brenner, Hermann Brucker, Sara Y Burwinkel, Barbara Caldas, Carlos Canzian, Federico Chang-Claude, Jenny Chanock, Stephen J Chin, Suet-Feung Clarke, Christine L Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Daly, Mary B Dennis, Joe Devilee, Peter Dunn, Janet A Dunning, Alison M Dwek, Miriam Earl, Helena M Eccles, Diana M Eliassen, A Heather Ellberg, Carolina Evans, D Gareth Fasching, Peter A Figueroa, Jonine Flyger, Henrik Gago-Dominguez, Manuela Gapstur, Susan M García-Closas, Montserrat García-Sáenz, José A Gaudet, Mia M George, Angela Giles, Graham G Goldgar, David E González-Neira, Anna Grip, Mervi Guénel, Pascal Guo, Qi Haiman, Christopher A Håkansson, Niclas Hamann, Ute Harrington, Patricia A Hiller, Louise Hooning, Maartje J Hopper, John L Howell, Anthony Huang, Chiun-Sheng Huang, Guanmengqian Hunter, David J Jakubowska, Anna John, Esther M Kaaks, Rudolf Kapoor, Pooja Middha Keeman, Renske Kitahara, Cari M Kraft, Peter Lambrechts, Diether Le Marchand, Loic Lejbkowicz, Flavio Lindblom, Annika Lubiński, Jan Mannermaa, Arto Manoochehri, Mehdi Manoukian, Siranoush Margolin, Sara Martinez, Maria Elena Maurer, Tabea Mavroudis, Dimitrios Meindl, Alfons Milne, Roger L Mulligan, Anna Marie Neuhausen, Susan L Nevanlinna, Heli Newman, William G Olshan, Andrew F Olson, Janet E Olsson, Håkan Orr, Nick Peterlongo, Paolo Petridis, Christos Prentice, Ross L Presneau, Nadege Punie, Kevin Ramachandran, Dhanya Rennert, Gad Romero, Atocha Sachchithananthan, Mythily Saloustros, Emmanouil Sawyer, Elinor J Schmutzler, Rita K Schwentner, Lukas Scott, Christopher Simard, Jacques Sohn, Christof Southey, Melissa C Swerdlow, Anthony J Tamimi, Rulla M Tapper, William J Teixeira, Manuel R Terry, Mary Beth Thorne, Heather Tollenaar, Rob A E M Tomlinson, Ian Troester, Melissa A Truong, Thérèse Turnbull, Clare Vachon, Celine M van der Kolk, Lizet E Wang, Qin Winqvist, Robert Wolk, Alicja Yang, Xiaohong R Ziogas, Argyrios Pharoah, Paul D P Hall, Per Wessels, Lodewyk F A Chenevix-Trench, Georgia Bader, Gary D Dörk, Thilo Easton, Douglas F Canisius, Sander Schmidt, Marjanka K Gonzalez Neira, Anna Andrulis, Irene L. Auer, Paul L. Beckmann, Matthias W. Bogdanova, Natalia V. Bojesen, Stig E. Bolla, Manjeet K. Brucker, Sara Y. Chanock, Stephen J. Clarke, Christine L. Couch, Fergus J. Cross, Simon S. Daly, Mary B. Dunn, Janet A. Dunning, Alison M. Earl, Helena M. Eccles, Diana M. Eliassen, A. Heather Evans, D. Gareth Fasching, Peter A. Gapstur, Susan M. García-Sáenz, José A. Gaudet, Mia M. Giles, Graham G. Goldgar, David E. Haiman, Christopher A. Harrington, Patricia A. Hooning, Maartje J. Hopper, John L. Hunter, David J. John, Esther M. Kitahara, Cari M. Koppert, Linetta B Kristensen, Vessela N Milne, Roger L. Neuhausen, Susan L. Newman, William G. Olshan, Andrew F. Olson, Janet E. Prentice, Ross L. Sawyer, Elinor J. Schmutzler, Rita K. Southey, Melissa C. Swerdlow, Anthony J. Tamimi, Rulla M. Tapper, William J. Tollenaar, Rob A. E. M. Troester, Melissa A. Vachon, Celine M. van der Kolk, Lizet E. Yang, Xiaohong R. Pharoah, Paul D. P. Wessels, Lodewyk F. A. Bader, Gary D. Easton, Douglas F. Schmidt, Marjanka K.
author_role	author
author2	Abraham, Jean Andrulis, Irene L Anton-Culver, Hoda Arndt, Volker Ashworth, Alan Auer, Paul L Auvinen, Päivi Beckmann, Matthias W Beesley, Jonathan Behrens, Sabine Benitez, Javier Bermisheva, Marina Blomqvist, Carl Blot, William Bogdanova, Natalia V Bojesen, Stig E Bolla, Manjeet K Børresen-Dale, Anne-Lise Brauch, Hiltrud Brenner, Hermann Brucker, Sara Y Burwinkel, Barbara Caldas, Carlos Canzian, Federico Chang-Claude, Jenny Chanock, Stephen J Chin, Suet-Feung Clarke, Christine L Couch, Fergus J Cox, Angela Cross, Simon S Czene, Kamila Daly, Mary B Dennis, Joe Devilee, Peter Dunn, Janet A Dunning, Alison M Dwek, Miriam Earl, Helena M Eccles, Diana M Eliassen, A Heather Ellberg, Carolina Evans, D Gareth Fasching, Peter A Figueroa, Jonine Flyger, Henrik Gago-Dominguez, Manuela Gapstur, Susan M García-Closas, Montserrat García-Sáenz, José A Gaudet, Mia M George, Angela Giles, Graham G Goldgar, David E González-Neira, Anna Grip, Mervi Guénel, Pascal Guo, Qi Haiman, Christopher A Håkansson, Niclas Hamann, Ute Harrington, Patricia A Hiller, Louise Hooning, Maartje J Hopper, John L Howell, Anthony Huang, Chiun-Sheng Huang, Guanmengqian Hunter, David J Jakubowska, Anna John, Esther M Kaaks, Rudolf Kapoor, Pooja Middha Keeman, Renske Kitahara, Cari M Kraft, Peter Lambrechts, Diether Le Marchand, Loic Lejbkowicz, Flavio Lindblom, Annika Lubiński, Jan Mannermaa, Arto Manoochehri, Mehdi Manoukian, Siranoush Margolin, Sara Martinez, Maria Elena Maurer, Tabea Mavroudis, Dimitrios Meindl, Alfons Milne, Roger L Mulligan, Anna Marie Neuhausen, Susan L Nevanlinna, Heli Newman, William G Olshan, Andrew F Olson, Janet E Olsson, Håkan Orr, Nick Peterlongo, Paolo Petridis, Christos Prentice, Ross L Presneau, Nadege Punie, Kevin Ramachandran, Dhanya Rennert, Gad Romero, Atocha Sachchithananthan, Mythily Saloustros, Emmanouil Sawyer, Elinor J Schmutzler, Rita K Schwentner, Lukas Scott, Christopher Simard, Jacques Sohn, Christof Southey, Melissa C Swerdlow, Anthony J Tamimi, Rulla M Tapper, William J Teixeira, Manuel R Terry, Mary Beth Thorne, Heather Tollenaar, Rob A E M Tomlinson, Ian Troester, Melissa A Truong, Thérèse Turnbull, Clare Vachon, Celine M van der Kolk, Lizet E Wang, Qin Winqvist, Robert Wolk, Alicja Yang, Xiaohong R Ziogas, Argyrios Pharoah, Paul D P Hall, Per Wessels, Lodewyk F A Chenevix-Trench, Georgia Bader, Gary D Dörk, Thilo Easton, Douglas F Canisius, Sander Schmidt, Marjanka K Gonzalez Neira, Anna Andrulis, Irene L. Auer, Paul L. Beckmann, Matthias W. Bogdanova, Natalia V. Bojesen, Stig E. Bolla, Manjeet K. Brucker, Sara Y. Chanock, Stephen J. Clarke, Christine L. Couch, Fergus J. Cross, Simon S. Daly, Mary B. Dunn, Janet A. Dunning, Alison M. Earl, Helena M. Eccles, Diana M. Eliassen, A. Heather Evans, D. Gareth Fasching, Peter A. Gapstur, Susan M. García-Sáenz, José A. Gaudet, Mia M. Giles, Graham G. Goldgar, David E. Haiman, Christopher A. Harrington, Patricia A. Hooning, Maartje J. Hopper, John L. Hunter, David J. John, Esther M. Kitahara, Cari M. Koppert, Linetta B Kristensen, Vessela N Milne, Roger L. Neuhausen, Susan L. Newman, William G. Olshan, Andrew F. Olson, Janet E. Prentice, Ross L. Sawyer, Elinor J. Schmutzler, Rita K. Southey, Melissa C. Swerdlow, Anthony J. Tamimi, Rulla M. Tapper, William J. Tollenaar, Rob A. E. M. Troester, Melissa A. Vachon, Celine M. van der Kolk, Lizet E. Yang, Xiaohong R. Pharoah, Paul D. P. Wessels, Lodewyk F. A. Bader, Gary D. Easton, Douglas F. Schmidt, Marjanka K.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	National Institute for Health Research (Reino Unido) German Cancer Research Center United States Department of Health and Human Services Cancer Research UK (Reino Unido) Unión Europea. Comisión Europea Canadian Institutes of Health Research Ministere de l'Economie, Science et Innovation du Quebec (Canadá) Dutch Cancer Society (Holanda) Instituto de Salud Carlos III Asociación Española Contra el Cáncer Deutsche Krebshilfe Russian Foundation for Basic Research Swedish Research Council Breast Cancer Now (Reino Unido)
dc.subject.none.fl_str_mv	Genetic Variation Genome-Wide Association Study Germ Cells Apoptosis Breast Neoplasms Circadian Clocks Computational Biology Female GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits, Gq-G11 Gene Regulatory Networks Genotype Humans Prognosis Receptors, Estrogen Signal Transduction
topic	Genetic Variation Genome-Wide Association Study Germ Cells Apoptosis Breast Neoplasms Circadian Clocks Computational Biology Female GTP-Binding Protein alpha Subunits GTP-Binding Protein alpha Subunits, Gq-G11 Gene Regulatory Networks Genotype Humans Prognosis Receptors, Estrogen Signal Transduction
description	Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.
publishDate	2020
dc.date.none.fl_str_mv	2020 2020-11-01 2020 2020-11-01 2021 2021-03-10
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/12181
url	http://hdl.handle.net/20.500.12105/12181
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	ES PI11 00923 ES PI12 00070 ES RD06 0020 ES PI13 00061 ES PI13 01162 ES PI13 01136 ES FIS PI17 00918 ES FIS PI12 02125
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución-NoComercial-CompartirIgual 4.0 Internacional http://creativecommons.org/licenses/by-nc-sa/4.0/
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dc.publisher.none.fl_str_mv	Nature Publishing Group
publisher.none.fl_str_mv	Nature Publishing Group
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
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spelling	A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.Escala-Garcia, MariaAbraham, JeanAndrulis, Irene LAnton-Culver, HodaArndt, VolkerAshworth, AlanAuer, Paul LAuvinen, PäiviBeckmann, Matthias WBeesley, JonathanBehrens, SabineBenitez, JavierBermisheva, MarinaBlomqvist, CarlBlot, WilliamBogdanova, Natalia VBojesen, Stig EBolla, Manjeet KBørresen-Dale, Anne-LiseBrauch, HiltrudBrenner, HermannBrucker, Sara YBurwinkel, BarbaraCaldas, CarlosCanzian, FedericoChang-Claude, JennyChanock, Stephen JChin, Suet-FeungClarke, Christine LCouch, Fergus JCox, AngelaCross, Simon SCzene, KamilaDaly, Mary BDennis, JoeDevilee, PeterDunn, Janet ADunning, Alison MDwek, MiriamEarl, Helena MEccles, Diana MEliassen, A HeatherEllberg, CarolinaEvans, D GarethFasching, Peter AFigueroa, JonineFlyger, HenrikGago-Dominguez, ManuelaGapstur, Susan MGarcía-Closas, MontserratGarcía-Sáenz, José AGaudet, Mia MGeorge, AngelaGiles, Graham GGoldgar, David EGonzález-Neira, AnnaGrip, MerviGuénel, PascalGuo, QiHaiman, Christopher AHåkansson, NiclasHamann, UteHarrington, Patricia AHiller, LouiseHooning, Maartje JHopper, John LHowell, AnthonyHuang, Chiun-ShengHuang, GuanmengqianHunter, David JJakubowska, AnnaJohn, Esther MKaaks, RudolfKapoor, Pooja MiddhaKeeman, RenskeKitahara, Cari MKraft, PeterLambrechts, DietherLe Marchand, LoicLejbkowicz, FlavioLindblom, AnnikaLubiński, JanMannermaa, ArtoManoochehri, MehdiManoukian, SiranoushMargolin, SaraMartinez, Maria ElenaMaurer, TabeaMavroudis, DimitriosMeindl, AlfonsMilne, Roger LMulligan, Anna MarieNeuhausen, Susan LNevanlinna, HeliNewman, William GOlshan, Andrew FOlson, Janet EOlsson, HåkanOrr, NickPeterlongo, PaoloPetridis, ChristosPrentice, Ross LPresneau, NadegePunie, KevinRamachandran, DhanyaRennert, GadRomero, AtochaSachchithananthan, MythilySaloustros, EmmanouilSawyer, Elinor JSchmutzler, Rita KSchwentner, LukasScott, ChristopherSimard, JacquesSohn, ChristofSouthey, Melissa CSwerdlow, Anthony JTamimi, Rulla MTapper, William JTeixeira, Manuel RTerry, Mary BethThorne, HeatherTollenaar, Rob A E MTomlinson, IanTroester, Melissa ATruong, ThérèseTurnbull, ClareVachon, Celine Mvan der Kolk, Lizet EWang, QinWinqvist, RobertWolk, AlicjaYang, Xiaohong RZiogas, ArgyriosPharoah, Paul D PHall, PerWessels, Lodewyk F AChenevix-Trench, GeorgiaBader, Gary DDörk, ThiloEaston, Douglas FCanisius, SanderSchmidt, Marjanka KGonzalez Neira, AnnaAndrulis, Irene L.Auer, Paul L.Beckmann, Matthias W.Bogdanova, Natalia V.Bojesen, Stig E.Bolla, Manjeet K.Brucker, Sara Y.Chanock, Stephen J.Clarke, Christine L.Couch, Fergus J.Cross, Simon S.Daly, Mary B.Dunn, Janet A.Dunning, Alison M.Earl, Helena M.Eccles, Diana M.Eliassen, A. HeatherEvans, D. GarethFasching, Peter A.Gapstur, Susan M.García-Sáenz, José A.Gaudet, Mia M.Giles, Graham G.Goldgar, David E.Haiman, Christopher A.Harrington, Patricia A.Hooning, Maartje J.Hopper, John L.Hunter, David J.John, Esther M.Kitahara, Cari M.Koppert, Linetta BKristensen, Vessela NMilne, Roger L.Neuhausen, Susan L.Newman, William G.Olshan, Andrew F.Olson, Janet E.Prentice, Ross L.Sawyer, Elinor J.Schmutzler, Rita K.Southey, Melissa C.Swerdlow, Anthony J.Tamimi, Rulla M.Tapper, William J.Tollenaar, Rob A. E. M.Troester, Melissa A.Vachon, Celine M.van der Kolk, Lizet E.Yang, Xiaohong R.Pharoah, Paul D. P.Wessels, Lodewyk F. A.Bader, Gary D.Easton, Douglas F.Schmidt, Marjanka K.Genetic VariationGenome-Wide Association StudyGerm CellsApoptosisBreast NeoplasmsCircadian ClocksComputational BiologyFemaleGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11Gene Regulatory NetworksGenotypeHumansPrognosisReceptors, EstrogenSignal TransductionIdentifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis.Nature Publishing GroupNational Institute for Health Research (Reino Unido)German Cancer Research CenterUnited States Department of Health and Human ServicesCancer Research UK (Reino Unido)Unión Europea. Comisión EuropeaCanadian Institutes of Health ResearchMinistere de l'Economie, Science et Innovation du Quebec (Canadá)Dutch Cancer Society (Holanda)Instituto de Salud Carlos IIIAsociación Española Contra el CáncerDeutsche KrebshilfeRussian Foundation for Basic ResearchSwedish Research CouncilBreast Cancer Now (Reino Unido)20212021-03-1020202020-11-0120202020-11-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/pdfhttp://hdl.handle.net/20.500.12105/12181reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PI11 00923ES PI12 00070ES RD06 0020ES PI13 00061ES PI13 01162ES PI13 01136ES FIS PI17 00918ES FIS PI12 02125open accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/121812026-06-12T12:43:37Z
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A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.

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