Sex-associated differences in cardiac ageing: Clinical aspects and molecular mechanisms

Despite the extensive clinical and scientific advances in prevention, diagnostics and treatment, cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality worldwide for people aged 65 and over. Of all ageing-related diseases, CVD are responsible for almost one-third of deaths...

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Autores: Calvo López, Margarita, Ortega Paz, Luis, Jimenez Trinidad, Francisco Rafael, Brugaletta, Salvatore, Sabaté, Manel, Dantas, Ana Paula
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/219884
Acceso en línea:https://hdl.handle.net/2445/219884
Access Level:acceso abierto
Palabra clave:Malalties cardiovasculars
Inflamació
Diferències entre sexes
Epigenètica
Envelliment
Cardiovascular diseases
Inflammation
Sex differences
Epigenetics
Aging
id ES_4e8bb62f09e388e3a34241dabfc00dcc
oai_identifier_str oai:diposit.ub.edu:2445/219884
network_acronym_str ES
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repository_id_str
spelling Sex-associated differences in cardiac ageing: Clinical aspects and molecular mechanismsCalvo López, MargaritaOrtega Paz, LuisJimenez Trinidad, Francisco RafaelBrugaletta, SalvatoreSabaté, ManelDantas, Ana PaulaMalalties cardiovascularsInflamacióDiferències entre sexesEpigenèticaEnvellimentCardiovascular diseasesInflammationSex differencesEpigeneticsAgingDespite the extensive clinical and scientific advances in prevention, diagnostics and treatment, cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality worldwide for people aged 65 and over. Of all ageing-related diseases, CVD are responsible for almost one-third of deaths in the elderly, being above all cancers combined. Age is an independent and unavoidable risk factor contributing to the impairment of heart and blood vessels. As the average age of the population in industrialized countries has doubled in the last century, and almost a fifth of the world's population is predicted to be over 65 in the next decade, we can assume that the burden of CVD will fall primarily on the elderly. Evidence from basic and clinical science has shown that sex significantly influences the onset and severity of CVD. In women, CVD usually develop later than in men and with atypical symptomatology. After menopause, however, the incidence and severity of CVD increase in women, reaching equality in both sexes. Although intrinsic sexual dimorphism in cardiovascular ageing may contribute to the sex differences in CVD progression, the molecular mechanisms associated with cardiovascular ageing and their clinical value are not known in detail. In this review, we discuss the scientific knowledge available, focusing on structural, hormonal, genetic/epigenetic and inflammatory pathways, seeking to transfer these findings to the cardiovascular clinic in terms of prevention, diagnosis, prognosis and management of these pathologies and proposing possible validation of target specifics.John Wiley & Sons2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/219884Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1111/eci.14215.European Journal of Clinical Investigation, 2024, vol. 54, num.7, p. e14215https://doi.org/10.1111/eci.14215.(c) Stichting European Society for Clinical Investigation Journal Foundation, 2024info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2198842026-05-27T06:46:51Z
dc.title.none.fl_str_mv Sex-associated differences in cardiac ageing: Clinical aspects and molecular mechanisms
title Sex-associated differences in cardiac ageing: Clinical aspects and molecular mechanisms
spellingShingle Sex-associated differences in cardiac ageing: Clinical aspects and molecular mechanisms
Calvo López, Margarita
Malalties cardiovasculars
Inflamació
Diferències entre sexes
Epigenètica
Envelliment
Cardiovascular diseases
Inflammation
Sex differences
Epigenetics
Aging
title_short Sex-associated differences in cardiac ageing: Clinical aspects and molecular mechanisms
title_full Sex-associated differences in cardiac ageing: Clinical aspects and molecular mechanisms
title_fullStr Sex-associated differences in cardiac ageing: Clinical aspects and molecular mechanisms
title_full_unstemmed Sex-associated differences in cardiac ageing: Clinical aspects and molecular mechanisms
title_sort Sex-associated differences in cardiac ageing: Clinical aspects and molecular mechanisms
dc.creator.none.fl_str_mv Calvo López, Margarita
Ortega Paz, Luis
Jimenez Trinidad, Francisco Rafael
Brugaletta, Salvatore
Sabaté, Manel
Dantas, Ana Paula
author Calvo López, Margarita
author_facet Calvo López, Margarita
Ortega Paz, Luis
Jimenez Trinidad, Francisco Rafael
Brugaletta, Salvatore
Sabaté, Manel
Dantas, Ana Paula
author_role author
author2 Ortega Paz, Luis
Jimenez Trinidad, Francisco Rafael
Brugaletta, Salvatore
Sabaté, Manel
Dantas, Ana Paula
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Malalties cardiovasculars
Inflamació
Diferències entre sexes
Epigenètica
Envelliment
Cardiovascular diseases
Inflammation
Sex differences
Epigenetics
Aging
topic Malalties cardiovasculars
Inflamació
Diferències entre sexes
Epigenètica
Envelliment
Cardiovascular diseases
Inflammation
Sex differences
Epigenetics
Aging
description Despite the extensive clinical and scientific advances in prevention, diagnostics and treatment, cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality worldwide for people aged 65 and over. Of all ageing-related diseases, CVD are responsible for almost one-third of deaths in the elderly, being above all cancers combined. Age is an independent and unavoidable risk factor contributing to the impairment of heart and blood vessels. As the average age of the population in industrialized countries has doubled in the last century, and almost a fifth of the world's population is predicted to be over 65 in the next decade, we can assume that the burden of CVD will fall primarily on the elderly. Evidence from basic and clinical science has shown that sex significantly influences the onset and severity of CVD. In women, CVD usually develop later than in men and with atypical symptomatology. After menopause, however, the incidence and severity of CVD increase in women, reaching equality in both sexes. Although intrinsic sexual dimorphism in cardiovascular ageing may contribute to the sex differences in CVD progression, the molecular mechanisms associated with cardiovascular ageing and their clinical value are not known in detail. In this review, we discuss the scientific knowledge available, focusing on structural, hormonal, genetic/epigenetic and inflammatory pathways, seeking to transfer these findings to the cardiovascular clinic in terms of prevention, diagnosis, prognosis and management of these pathologies and proposing possible validation of target specifics.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219884
url https://hdl.handle.net/2445/219884
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1111/eci.14215.
European Journal of Clinical Investigation, 2024, vol. 54, num.7, p. e14215
https://doi.org/10.1111/eci.14215.
dc.rights.none.fl_str_mv (c) Stichting European Society for Clinical Investigation Journal Foundation, 2024
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Stichting European Society for Clinical Investigation Journal Foundation, 2024
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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