Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.

González Segura, Àlex; Prohens Coll, Llucia; Julià, Laura; Amoretti Guadall, Silvia; RIbero Rodríguez, Maria; Pino Camacho, Laura; Cano Escalera, Guillermo; Mané, Anna; Rodriguez Jimenez, Roberto; Roldán, Alexandra; Sarró, Salvador; Ibáñez Cuadrado, Ángela; Usall i Rodié, Judith; Lobo, Antonio; García Rizo, Clemente; Cuesta, Manuel J.; Parellada, Mara; González-Pinto, Ana; Berrocoso, Esther; Bernardo Arroyo, Miquel; Mas Herrero, Sergi; Rodríguez Ferret, Natalia

Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.

Both genetic and environmental factors have been found to play a significant role in psychosis relapse, either independently or through their synergistic interaction. Recently, DNA methylation (DNAm) has been proposed through the calculation of methylation profile scores (MPS). The aim of the presen...

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Detalhes bibliográficos
Autores:	González Segura, Àlex, Prohens Coll, Llucia, Julià, Laura, Amoretti Guadall, Silvia, RIbero Rodríguez, Maria, Pino Camacho, Laura, Cano Escalera, Guillermo, Mané, Anna, Rodriguez Jimenez, Roberto, Roldán, Alexandra, Sarró, Salvador, Ibáñez Cuadrado, Ángela, Usall i Rodié, Judith, Lobo, Antonio, García Rizo, Clemente, Cuesta, Manuel J., Parellada, Mara, González-Pinto, Ana, Berrocoso, Esther, Bernardo Arroyo, Miquel, Mas Herrero, Sergi, Rodríguez Ferret, Natalia
Formato:	artículo
Estado:	Versión publicada
Fecha de publicación:	2025
País:	España
Recursos:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/227759
Acesso em linha:	https://hdl.handle.net/2445/227759
Access Level:	acceso abierto
Palavra-chave:	Esquizofrènia Metilació Epigenètica Schizophrenia Methylation Epigenetics

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spelling	Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.González Segura, ÀlexProhens Coll, LluciaJulià, LauraAmoretti Guadall, SilviaRIbero Rodríguez, MariaPino Camacho, LauraCano Escalera, GuillermoMané, AnnaRodriguez Jimenez, RobertoRoldán, AlexandraSarró, SalvadorIbáñez Cuadrado, ÁngelaUsall i Rodié, JudithLobo, AntonioGarcía Rizo, ClementeCuesta, Manuel J.Parellada, MaraGonzález-Pinto, AnaBerrocoso, EstherBernardo Arroyo, MiquelMas Herrero, SergiRodríguez Ferret, NataliaEsquizofrèniaMetilacióEpigenèticaSchizophreniaMethylationEpigeneticsBoth genetic and environmental factors have been found to play a significant role in psychosis relapse, either independently or through their synergistic interaction. Recently, DNA methylation (DNAm) has been proposed through the calculation of methylation profile scores (MPS). The aim of the present study is to evaluate the association of MPS as a surrogate marker of the biological impact of early stressful life events (including stressful intrauterine conditions and obstetric complications, childhood adversity and toxic habits), with the risk of schizophrenia (SCZ) relapse. 91 participants from a cohort of first-episode schizophrenia (FES) patients with less than five years of evolution were classified as non-relapse (patients who had not experienced a relapse after 3 years of enrollment) or relapse (patients who relapsed during the 3-year follow-up). As inclusion criteria, patients fulfilled Andreasen’s criteria of symptomatic remission. Genome-wide DNA methylation (DNAm) was profiled and fourteen MPS reflecting environmental exposure were constructed including both early stressful life events (including stressful intrauterine conditions and delivery issues, childhood adversity) and toxic habits. Increased levels of MPS reflecting gestational diabetes (p = 0.009), hypertensive disorders during pregnancy (p = 0.004), pre-eclampsia (p = 0.049), early preterm birth (p = 0.030), childhood adversity abuse (p = 0.021) and all childhood adversity (p = 0.030) were significantly associated with an increased risk of relapse. Our study suggests that changes in specific methylation patterns may represent one of the biological mechanisms linking early stressful life events to an increased risk of relapse.Elsevier B.V.2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/227759Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.euroneuro.2025.02.003European Neuropsychopharmacology, 2025, vol. 94, p. 4-15https://doi.org/10.1016/j.euroneuro.2025.02.003cc-by (c) González Segura, Àlex, et al., 2025http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2277592026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.
title	Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.
spellingShingle	Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia. González Segura, Àlex Esquizofrènia Metilació Epigenètica Schizophrenia Methylation Epigenetics
title_short	Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.
title_full	Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.
title_fullStr	Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.
title_full_unstemmed	Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.
title_sort	Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.
dc.creator.none.fl_str_mv	González Segura, Àlex Prohens Coll, Llucia Julià, Laura Amoretti Guadall, Silvia RIbero Rodríguez, Maria Pino Camacho, Laura Cano Escalera, Guillermo Mané, Anna Rodriguez Jimenez, Roberto Roldán, Alexandra Sarró, Salvador Ibáñez Cuadrado, Ángela Usall i Rodié, Judith Lobo, Antonio García Rizo, Clemente Cuesta, Manuel J. Parellada, Mara González-Pinto, Ana Berrocoso, Esther Bernardo Arroyo, Miquel Mas Herrero, Sergi Rodríguez Ferret, Natalia
author	González Segura, Àlex
author_facet	González Segura, Àlex Prohens Coll, Llucia Julià, Laura Amoretti Guadall, Silvia RIbero Rodríguez, Maria Pino Camacho, Laura Cano Escalera, Guillermo Mané, Anna Rodriguez Jimenez, Roberto Roldán, Alexandra Sarró, Salvador Ibáñez Cuadrado, Ángela Usall i Rodié, Judith Lobo, Antonio García Rizo, Clemente Cuesta, Manuel J. Parellada, Mara González-Pinto, Ana Berrocoso, Esther Bernardo Arroyo, Miquel Mas Herrero, Sergi Rodríguez Ferret, Natalia
author_role	author
author2	Prohens Coll, Llucia Julià, Laura Amoretti Guadall, Silvia RIbero Rodríguez, Maria Pino Camacho, Laura Cano Escalera, Guillermo Mané, Anna Rodriguez Jimenez, Roberto Roldán, Alexandra Sarró, Salvador Ibáñez Cuadrado, Ángela Usall i Rodié, Judith Lobo, Antonio García Rizo, Clemente Cuesta, Manuel J. Parellada, Mara González-Pinto, Ana Berrocoso, Esther Bernardo Arroyo, Miquel Mas Herrero, Sergi Rodríguez Ferret, Natalia
author2_role	author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Esquizofrènia Metilació Epigenètica Schizophrenia Methylation Epigenetics
topic	Esquizofrènia Metilació Epigenètica Schizophrenia Methylation Epigenetics
description	Both genetic and environmental factors have been found to play a significant role in psychosis relapse, either independently or through their synergistic interaction. Recently, DNA methylation (DNAm) has been proposed through the calculation of methylation profile scores (MPS). The aim of the present study is to evaluate the association of MPS as a surrogate marker of the biological impact of early stressful life events (including stressful intrauterine conditions and obstetric complications, childhood adversity and toxic habits), with the risk of schizophrenia (SCZ) relapse. 91 participants from a cohort of first-episode schizophrenia (FES) patients with less than five years of evolution were classified as non-relapse (patients who had not experienced a relapse after 3 years of enrollment) or relapse (patients who relapsed during the 3-year follow-up). As inclusion criteria, patients fulfilled Andreasen’s criteria of symptomatic remission. Genome-wide DNA methylation (DNAm) was profiled and fourteen MPS reflecting environmental exposure were constructed including both early stressful life events (including stressful intrauterine conditions and delivery issues, childhood adversity) and toxic habits. Increased levels of MPS reflecting gestational diabetes (p = 0.009), hypertensive disorders during pregnancy (p = 0.004), pre-eclampsia (p = 0.049), early preterm birth (p = 0.030), childhood adversity abuse (p = 0.021) and all childhood adversity (p = 0.030) were significantly associated with an increased risk of relapse. Our study suggests that changes in specific methylation patterns may represent one of the biological mechanisms linking early stressful life events to an increased risk of relapse.
publishDate	2025
dc.date.none.fl_str_mv	2025 2026 2026 2026
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/227759
url	https://hdl.handle.net/2445/227759
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1016/j.euroneuro.2025.02.003 European Neuropsychopharmacology, 2025, vol. 94, p. 4-15 https://doi.org/10.1016/j.euroneuro.2025.02.003
dc.rights.none.fl_str_mv	cc-by (c) González Segura, Àlex, et al., 2025 http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) González Segura, Àlex, et al., 2025 http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	12 p. application/pdf
dc.publisher.none.fl_str_mv	Elsevier B.V.
publisher.none.fl_str_mv	Elsevier B.V.
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia.

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