Analysis of the relationship between the rise-time and the amplitude of single-fibre potentials in human muscles
Using the core-conductor theory, a single fibre action potential (SFAP) can be expressed as the convolution of a biolectrical source and a weight function. In the Dimitrov¿Dimitrova (D¿D) SFAP convolutional model, the first temporal derivative of the intracellular action potential (IAP) is used as t...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2010 |
| País: | España |
| Institución: | Universidad Pública de Navarra |
| Repositorio: | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| OAI Identifier: | oai:academica-e.unavarra.es:2454/55566 |
| Acceso en línea: | https://hdl.handle.net/2454/55566 |
| Access Level: | acceso abierto |
| Palabra clave: | SFAP convolutional model SFAP rise-time IAP spatial profile Core-conductor theory Needle movement |
| Sumario: | Using the core-conductor theory, a single fibre action potential (SFAP) can be expressed as the convolution of a biolectrical source and a weight function. In the Dimitrov¿Dimitrova (D¿D) SFAP convolutional model, the first temporal derivative of the intracellular action potential (IAP) is used as the source. The present work evaluates the relationship between the SFAP peak-to-peak amplitude (Vpp) and peak-topeak interval (rise-time, RT) at different fibre-to-electrode distances using simulated signals obtained by the D¿D model as well as real recordings. With a single fibre electrode, we recorded 63 sets of consecutive SFAPs from the m. tibialis anterior of four normal subjects. The needle was intentionally moved whilst recording each SFAP set. We used the observed changes in RT and Vpp within each SFAP set as a point of reference with which to evaluate how closely the relationship between RT and Vpp provided by the D¿D model reflects real data. We found that half of the recorded SFAP sets had rise-times higher than those generated by the D¿D model. We also showed the influence of the IAP spatial length on the sensitivity of RT and Vpp with radial distance. The study reveals some inaccuracies in simulated SFAPs whose origin might be related to the assumptions made in the core-conductor theory. |
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