The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying...

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Detalles Bibliográficos
Autores: Sánchez-García, Laura|||0000-0002-8420-1701, Serna, Naroa|||0000-0001-5682-8198, Mattanovich, M., Cazzanelli, P., Sánchez Chardi, Alejandro|||0000-0002-8789-1883, Conchillo-Solé, Oscar|||0000-0003-4266-246X, Cortés López, Francisco, Daura i Ribera, Xavier|||0000-0001-9235-6730, Unzueta Elorza, Ugutz|||0000-0001-5119-2266, Mangues, Ramon|||0000-0003-2661-9525, Villaverde, Antonio|||0000-0002-2615-4521, Vázquez, Esther|||0000-0003-1052-0424
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:225214
Acceso en línea:https://ddd.uab.cat/record/225214
https://dx.doi.org/urn:doi:10.1039/c6cc09900a
Access Level:acceso abierto
Palabra clave:Drug Carriers
Endosomes
Fluorescence
HeLa Cells
Hemagglutinins, Viral
Humans
Nanoparticles
Receptors, Cell Surface
Receptors, CXCR4
Tumor Cells, Cultured
Descripción
Sumario:We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.

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