Structure of the yeast mitochondrial large ribosomal subunit

6 páginas, 6 figuras. Contiete material suplementario

Detalles Bibliográficos
Autores: Amunts, Alexey, Brown, Alan, Bai, Xiao-chen, Llácer, José Luis, Hussain, Tanweer, Emsley, Paul, Long, Fei, Murshudov, Garib, Scheres, Sjors H.W., Ramakrishnan, V.
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/176132
Acceso en línea:http://hdl.handle.net/10261/176132
Access Level:acceso abierto
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spelling Structure of the yeast mitochondrial large ribosomal subunitAmunts, AlexeyBrown, AlanBai, Xiao-chenLlácer, José LuisHussain, TanweerEmsley, PaulLong, FeiMurshudov, GaribScheres, Sjors H.W.Ramakrishnan, V.6 páginas, 6 figuras. Contiete material suplementarioMitochondria have specialized ribosomes that have diverged from their bacterial and cytoplasmic counterparts. We have solved the structure of the yeast mitoribosomal large subunit using single-particle cryo-electron microscopy. The resolution of 3.2 angstroms enabled a nearly complete atomic model to be built de novo and refined, including 39 proteins, 13 of which are unique to mitochondria, as well as expansion segments of mitoribosomal RNA. The structure reveals a new exit tunnel path and architecture, unique elements of the E site, and a putative membrane docking site.This work was funded by grants from the UK Medical Research Council (MC_U105184332 to VR, MC_UP_A025_1013 to SHWS and MC_UP_A025_1012 to GM); a Wellcome Trust Senior Investigator award (WT096570), the Agouron Institute and the Jeantet Foundation (VR); fellowships from Human Frontiers Science Programme (AA), EU FP7 Marie Curie (XB), FEBS (JLL), and EMBO (TH). Cryo-EM density maps have been deposited with the EMDB (accession number EMD-2566) and coordinates have been deposited with the PDB (entry code 3J6B).Peer reviewedAmerican Association for the Advancement of ScienceMedical Research Council (UK)Agouron InstituteLouis Jeantet FoundationEuropean Research CouncilHuman Frontier Science ProgramFederation of European Biochemical SocietiesLlácer, José Luis [0000-0001-5304-1795]201920192014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/176132reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1126/science.1249410Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1761322026-05-22T06:33:51Z
dc.title.none.fl_str_mv Structure of the yeast mitochondrial large ribosomal subunit
title Structure of the yeast mitochondrial large ribosomal subunit
spellingShingle Structure of the yeast mitochondrial large ribosomal subunit
Amunts, Alexey
title_short Structure of the yeast mitochondrial large ribosomal subunit
title_full Structure of the yeast mitochondrial large ribosomal subunit
title_fullStr Structure of the yeast mitochondrial large ribosomal subunit
title_full_unstemmed Structure of the yeast mitochondrial large ribosomal subunit
title_sort Structure of the yeast mitochondrial large ribosomal subunit
dc.creator.none.fl_str_mv Amunts, Alexey
Brown, Alan
Bai, Xiao-chen
Llácer, José Luis
Hussain, Tanweer
Emsley, Paul
Long, Fei
Murshudov, Garib
Scheres, Sjors H.W.
Ramakrishnan, V.
author Amunts, Alexey
author_facet Amunts, Alexey
Brown, Alan
Bai, Xiao-chen
Llácer, José Luis
Hussain, Tanweer
Emsley, Paul
Long, Fei
Murshudov, Garib
Scheres, Sjors H.W.
Ramakrishnan, V.
author_role author
author2 Brown, Alan
Bai, Xiao-chen
Llácer, José Luis
Hussain, Tanweer
Emsley, Paul
Long, Fei
Murshudov, Garib
Scheres, Sjors H.W.
Ramakrishnan, V.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Medical Research Council (UK)
Agouron Institute
Louis Jeantet Foundation
European Research Council
Human Frontier Science Program
Federation of European Biochemical Societies
Llácer, José Luis [0000-0001-5304-1795]
description 6 páginas, 6 figuras. Contiete material suplementario
publishDate 2014
dc.date.none.fl_str_mv 2014
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/176132
url http://hdl.handle.net/10261/176132
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1126/science.1249410
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association for the Advancement of Science
publisher.none.fl_str_mv American Association for the Advancement of Science
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407749597560832
score 15.811543

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