EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma

Background: To evaluate whether EQD2(α/β = 3Gy) at 2 cm3 of the most exposed area of the vagina is related to late vaginal toxicity in postoperative endometrial cancer (PEC) patients (p) treated with exclusive brachytherapy (BT). Methods: From 2014 to 2017, 43p were included in this study. BT was ad...

Descripción completa

Detalles Bibliográficos
Autores: Zhang, Yaowen, Fornes, Balbino, Gómez, Gabriela, Bentoldrà, Irene, Carmona, Clara, Herreros, Antonio, Sabater, Sebastià, Nicolás, Inmaculada, Li, Yan, Sánchez, Joan, Biete Solà, Albert, Torné Bladé, Aureli, Ascaso Terrén, Carlos, Rovirosa Casino, Angeles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/179352
Acceso en línea:https://hdl.handle.net/2445/179352
Access Level:acceso abierto
Palabra clave:Càncer d'endometri
Radioteràpia
Endometrial cancer
Radiotherapy
id ES_4e51197360bb8df715a0cc4e9c272c2d
oai_identifier_str oai:recercat.cat:2445/179352
network_acronym_str ES
network_name_str España
repository_id_str
spelling EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial CarcinomaZhang, YaowenFornes, BalbinoGómez, GabrielaBentoldrà, IreneCarmona, ClaraHerreros, AntonioSabater, SebastiàNicolás, InmaculadaLi, YanSánchez, JoanBiete Solà, AlbertTorné Bladé, AureliAscaso Terrén, CarlosRovirosa Casino, AngelesCàncer d'endometriRadioteràpiaEndometrial cancerRadiotherapyBackground: To evaluate whether EQD2(α/β = 3Gy) at 2 cm3 of the most exposed area of the vagina is related to late vaginal toxicity in postoperative endometrial cancer (PEC) patients (p) treated with exclusive brachytherapy (BT). Methods: From 2014 to 2017, 43p were included in this study. BT was administered: 3-fractions of 6Gy in 37p and 2-fractions of 7.5Gy in 6p. The dose was prescribed at a depth of 5 mm from the applicator surface with dose-point optimization based on distance. The active treatment length was 2.5 cm. CTV-D90 and the dose to the most exposed 2 cm3 of the vagina was calculated for each patient. Late toxicity of the bladder and rectum was assessed using Radiation Therapy Oncology Group (RTOG) criteria, and vaginal toxicity by objective Late Effects Normal Tissue Task Force (LENT)-Subjective, Objective, Management, Analytic (SOMA) (LENT-SOMA) criteria. Statistics: frequency tables, mean, median, range, standard deviation, and box plot. Results: The median follow-up was 51 months (12-68). 20 p (46.5%) and 2 p (4.7%) developed G1 and G2 vaginal complications, respectively. Only 1/2 p-G2 receiving EQD2(α/β = 3Gy) at 2 cm3 >68Gy presented vaginal shortening and 18/20 p-G1 received doses < 68Gy. Conclusions: PECp receiving exclusive brachytherapy with doses < 68Gy EQD2(α/β = 3Gy) at 2 cm2 of the vagina presented only G0-G1 vaginal toxicity, except for one with bleeding telangiectasias. Larger prospective studies are necessary to confirm the present results.MDPI2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/179352Articles publicats en revistes (Fonaments Clínics)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/cancers12103059Cancers, 2020, vol. 12, num. 10, p. 3059https://doi.org/10.3390/cancers12103059cc-by (c) Zhang, Yaowen et al., 2020https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1793522026-05-29T05:05:01Z
dc.title.none.fl_str_mv EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma
title EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma
spellingShingle EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma
Zhang, Yaowen
Càncer d'endometri
Radioteràpia
Endometrial cancer
Radiotherapy
title_short EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma
title_full EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma
title_fullStr EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma
title_full_unstemmed EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma
title_sort EQD2 Analyses of Vaginal Complications in Exclusive Brachytherapy for Postoperative Endometrial Carcinoma
dc.creator.none.fl_str_mv Zhang, Yaowen
Fornes, Balbino
Gómez, Gabriela
Bentoldrà, Irene
Carmona, Clara
Herreros, Antonio
Sabater, Sebastià
Nicolás, Inmaculada
Li, Yan
Sánchez, Joan
Biete Solà, Albert
Torné Bladé, Aureli
Ascaso Terrén, Carlos
Rovirosa Casino, Angeles
author Zhang, Yaowen
author_facet Zhang, Yaowen
Fornes, Balbino
Gómez, Gabriela
Bentoldrà, Irene
Carmona, Clara
Herreros, Antonio
Sabater, Sebastià
Nicolás, Inmaculada
Li, Yan
Sánchez, Joan
Biete Solà, Albert
Torné Bladé, Aureli
Ascaso Terrén, Carlos
Rovirosa Casino, Angeles
author_role author
author2 Fornes, Balbino
Gómez, Gabriela
Bentoldrà, Irene
Carmona, Clara
Herreros, Antonio
Sabater, Sebastià
Nicolás, Inmaculada
Li, Yan
Sánchez, Joan
Biete Solà, Albert
Torné Bladé, Aureli
Ascaso Terrén, Carlos
Rovirosa Casino, Angeles
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer d'endometri
Radioteràpia
Endometrial cancer
Radiotherapy
topic Càncer d'endometri
Radioteràpia
Endometrial cancer
Radiotherapy
description Background: To evaluate whether EQD2(α/β = 3Gy) at 2 cm3 of the most exposed area of the vagina is related to late vaginal toxicity in postoperative endometrial cancer (PEC) patients (p) treated with exclusive brachytherapy (BT). Methods: From 2014 to 2017, 43p were included in this study. BT was administered: 3-fractions of 6Gy in 37p and 2-fractions of 7.5Gy in 6p. The dose was prescribed at a depth of 5 mm from the applicator surface with dose-point optimization based on distance. The active treatment length was 2.5 cm. CTV-D90 and the dose to the most exposed 2 cm3 of the vagina was calculated for each patient. Late toxicity of the bladder and rectum was assessed using Radiation Therapy Oncology Group (RTOG) criteria, and vaginal toxicity by objective Late Effects Normal Tissue Task Force (LENT)-Subjective, Objective, Management, Analytic (SOMA) (LENT-SOMA) criteria. Statistics: frequency tables, mean, median, range, standard deviation, and box plot. Results: The median follow-up was 51 months (12-68). 20 p (46.5%) and 2 p (4.7%) developed G1 and G2 vaginal complications, respectively. Only 1/2 p-G2 receiving EQD2(α/β = 3Gy) at 2 cm3 >68Gy presented vaginal shortening and 18/20 p-G1 received doses < 68Gy. Conclusions: PECp receiving exclusive brachytherapy with doses < 68Gy EQD2(α/β = 3Gy) at 2 cm2 of the vagina presented only G0-G1 vaginal toxicity, except for one with bleeding telangiectasias. Larger prospective studies are necessary to confirm the present results.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/179352
url https://hdl.handle.net/2445/179352
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers12103059
Cancers, 2020, vol. 12, num. 10, p. 3059
https://doi.org/10.3390/cancers12103059
dc.rights.none.fl_str_mv cc-by (c) Zhang, Yaowen et al., 2020
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Zhang, Yaowen et al., 2020
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Fonaments Clínics)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407748364435456
score 15,81155

Similares en LA Referencia