Association Between Norepinephrine Levels and Abnormal Iron Status in Patients With Chronic Heart Failure

Mechanisms underlying iron homeostasis dysregulation in patients with chronic heart failure remain unsettled. In cardiomyocyte models, norepinephrine may lead to intracellular iron depletion, but the potential association between catecholamines (sympathetic activation markers) and iron metabolism bi...

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Detalles Bibliográficos
Autores: Moliner, P.|||0000-0002-5511-8597, Enjuanes, Cristina|||0000-0002-7916-1223, Tajes, Marta, Cainzos-Achirica, Miguel|||0000-0002-3805-9089, Lupón, Josep|||0000-0002-5601-9611, Garay, Alberto, Jimenez-Marrero, Santiago, Yun, Sergi|||0000-0003-4858-9566, Farré, Núria|||0000-0003-3110-6572, Cladellas Capdevila, Mercè|||0000-0001-8537-6012, Díez-López, Carles|||0000-0002-3734-4777, González-Costello, José|||0000-0002-7437-3630, Comín-Colet, Josep|||0000-0001-8780-720X
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:226344
Acceso en línea:https://ddd.uab.cat/record/226344
https://dx.doi.org/urn:doi:10.1161/JAHA.118.010887
Access Level:acceso abierto
Palabra clave:Anemia
Chronic heart failure
Iron
Iron deficiency
Norepinephrine
Sympathetic nervous system
Biomarkers
Autonomic Nervous System
Heart Failure
Descripción
Sumario:Mechanisms underlying iron homeostasis dysregulation in patients with chronic heart failure remain unsettled. In cardiomyocyte models, norepinephrine may lead to intracellular iron depletion, but the potential association between catecholamines (sympathetic activation markers) and iron metabolism biomarkers in chronic heart failure is unknown. In this cross-sectional analysis, we studied the association between plasma norepinephrine levels and serum iron status biomarkers indicating iron storage (ferritin), iron transport (transferrin saturation), and iron demand (soluble transferrin receptor) in a prospective cohort of 742 chronic heart failure patients (mean age, 72±11 years; 56% male). Impaired iron status was defined as ferritin <100 μg/L or transferrin saturation <20%. Impaired iron status was observed in 69% of patients. In multivariate models, greater norepinephrine levels were associated with impaired iron transport (transferrin saturation <20%, odds ratio=2.28; 95% CI [1.19-4.35]; P =0.013), but not with impaired iron storage (ferritin <100 μg/L, odds ratio=1.25; 95% CI [0.73-2.16]; P =0.415). Norepinephrine was a significant predictor of increased iron demand (soluble transferrin receptor, standardized β-coefficient=0.12; P =0.006) and low transferrin saturation (standardized β-coefficient=-0.12; P =0.003). However, norepinephrine levels were not associated with iron or ferritin levels (P.

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