Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status

Background: Our study examines impact of HPV status and patient-specific characteristics on recurrence-free survival (RFS) and overall survival (OS) for SCC and ECA. Methods: This multi-continental retrospective study analyzed clinicopathologic data of 634 patients with microscopically confirmed cer...

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Authors: Jain, Deepti, Marya Wahidib, Effendib, Judy, Hoangc, Lien, Terinted, Cristina, Pescie, Anna, Kiyokawaf, Takako, Alvarado Cabrero, Isabel, Oliva, Esther, Rakislova, Natalia, Felix, Ana, Allison, Douglas, Guerrao, Esther, Romap, Andres, Fadare, Oluwole, Turashvili, Gulisa, Parra Herran, Carlos, Kirs, Gozde, Erbagci, Ahmet, Mills, Anne, Regauer, Sigrid, Ordi i Majà, Jaume, Jang, Hyejeong, Kim, Seongho, Gogoi, Radhika, Zannoni, Gian Franco, Mateoiu, Claudia, Lastra, Ricardo, Devins, Kyle, Horn, Lars-Christian, McCluggage, W. Glenn, Stolnicu, Simona, Ali-Fehmi, Rouba
Format: article
Status:Published version
Publication Date:2026
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/227680
Online Access:https://hdl.handle.net/2445/227680
Access Level:Open access
Keyword:Càncer de coll uterí
Papil·lomavirus
Cervix cancer
Papillomaviruses
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spelling Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV statusJain, DeeptiMarya WahidibEffendib, JudyHoangc, Lien Terinted, Cristina Pescie, Anna Kiyokawaf, Takako Alvarado Cabrero, Isabel Oliva, EstherRakislova, NataliaFelix, Ana Allison, Douglas Guerrao, Esther Romap, Andres Fadare, Oluwole Turashvili, Gulisa Parra Herran, Carlos Kirs, Gozde Erbagci, Ahmet Mills, AnneRegauer, Sigrid Ordi i Majà, JaumeJang, Hyejeong Kim, Seongho Gogoi, Radhika Zannoni, Gian FrancoMateoiu, Claudia Lastra, Ricardo Devins, Kyle Horn, Lars-Christian McCluggage, W. Glenn Stolnicu, Simona Ali-Fehmi, RoubaCàncer de coll uteríPapil·lomavirusCervix cancerPapillomavirusesBackground: Our study examines impact of HPV status and patient-specific characteristics on recurrence-free survival (RFS) and overall survival (OS) for SCC and ECA. Methods: This multi-continental retrospective study analyzed clinicopathologic data of 634 patients with microscopically confirmed cervical cancer (CC; only SCC and ECA) across Asia, Europe, and North America. HPV status was determined using PCR or HPV in situ hybridization (ISH) for both HR-HPV (SCC and ECA) and LR-HPV (SCC), using same platform. Descriptive analysis and Cox regression models were produced. Results: Out of total 634 patients, 533 (84.1%) were HPVA and 101 (15.9%) were HPVI. 65% had SCC morphology (88.1%: HPVA; 11.9%: HPVI) and 35% had ECA differentiation (76.6%: HPVA; 23.4%: HPVI). Compared to ECA, patients with SCC were older (median age: 51 vs. 45 years old; p < 0.001), had higher HPVA status (88.1% vs. 76.6%; p < 0.001), and a higher rate of lymph-vascular invasion (LVI; 64.8% vs. 56.8%; p = 0.004). However, patients with ECA had a higher rate of metastases to pelvic organs (13.5% vs. 2.4%; p < 0.001). In univariable analysis, HPV status, tumor type, higher FIGO stage, older age, LVI positive, lymph node metastasis (LNM), and adjuvant treatment were all associated with impaired RFS and OS (all p <= 0.007). In multivariable analysis, LVI, HPV status, institution, and tumor type remained significant for RFS, while age at diagnosis, FIGO stage, LVI, and tumor type remained significant for OS. Conclusion: Tumor type and HPV status play significant role in determining survival outcomes in CC. Elsevier BV2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/227680Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.ygyno.2026.01.012Gynecologic Oncology, 2026, vol. 205, p. 89-98https://doi.org/10.1016/j.ygyno.2026.01.012http:// creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2276802026-05-27T06:46:51Z
dc.title.none.fl_str_mv Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status
title Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status
spellingShingle Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status
Jain, Deepti
Càncer de coll uterí
Papil·lomavirus
Cervix cancer
Papillomaviruses
title_short Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status
title_full Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status
title_fullStr Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status
title_full_unstemmed Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status
title_sort Survival comparison analysis between cervical squamous cell carcinoma and adenocarcinoma with a special focus on the HPV status
dc.creator.none.fl_str_mv Jain, Deepti
Marya Wahidib
Effendib, Judy
Hoangc, Lien
Terinted, Cristina
Pescie, Anna
Kiyokawaf, Takako
Alvarado Cabrero, Isabel
Oliva, Esther
Rakislova, Natalia
Felix, Ana
Allison, Douglas
Guerrao, Esther
Romap, Andres
Fadare, Oluwole
Turashvili, Gulisa
Parra Herran, Carlos
Kirs, Gozde
Erbagci, Ahmet
Mills, Anne
Regauer, Sigrid
Ordi i Majà, Jaume
Jang, Hyejeong
Kim, Seongho
Gogoi, Radhika
Zannoni, Gian Franco
Mateoiu, Claudia
Lastra, Ricardo
Devins, Kyle
Horn, Lars-Christian
McCluggage, W. Glenn
Stolnicu, Simona
Ali-Fehmi, Rouba
author Jain, Deepti
author_facet Jain, Deepti
Marya Wahidib
Effendib, Judy
Hoangc, Lien
Terinted, Cristina
Pescie, Anna
Kiyokawaf, Takako
Alvarado Cabrero, Isabel
Oliva, Esther
Rakislova, Natalia
Felix, Ana
Allison, Douglas
Guerrao, Esther
Romap, Andres
Fadare, Oluwole
Turashvili, Gulisa
Parra Herran, Carlos
Kirs, Gozde
Erbagci, Ahmet
Mills, Anne
Regauer, Sigrid
Ordi i Majà, Jaume
Jang, Hyejeong
Kim, Seongho
Gogoi, Radhika
Zannoni, Gian Franco
Mateoiu, Claudia
Lastra, Ricardo
Devins, Kyle
Horn, Lars-Christian
McCluggage, W. Glenn
Stolnicu, Simona
Ali-Fehmi, Rouba
author_role author
author2 Marya Wahidib
Effendib, Judy
Hoangc, Lien
Terinted, Cristina
Pescie, Anna
Kiyokawaf, Takako
Alvarado Cabrero, Isabel
Oliva, Esther
Rakislova, Natalia
Felix, Ana
Allison, Douglas
Guerrao, Esther
Romap, Andres
Fadare, Oluwole
Turashvili, Gulisa
Parra Herran, Carlos
Kirs, Gozde
Erbagci, Ahmet
Mills, Anne
Regauer, Sigrid
Ordi i Majà, Jaume
Jang, Hyejeong
Kim, Seongho
Gogoi, Radhika
Zannoni, Gian Franco
Mateoiu, Claudia
Lastra, Ricardo
Devins, Kyle
Horn, Lars-Christian
McCluggage, W. Glenn
Stolnicu, Simona
Ali-Fehmi, Rouba
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer de coll uterí
Papil·lomavirus
Cervix cancer
Papillomaviruses
topic Càncer de coll uterí
Papil·lomavirus
Cervix cancer
Papillomaviruses
description Background: Our study examines impact of HPV status and patient-specific characteristics on recurrence-free survival (RFS) and overall survival (OS) for SCC and ECA. Methods: This multi-continental retrospective study analyzed clinicopathologic data of 634 patients with microscopically confirmed cervical cancer (CC; only SCC and ECA) across Asia, Europe, and North America. HPV status was determined using PCR or HPV in situ hybridization (ISH) for both HR-HPV (SCC and ECA) and LR-HPV (SCC), using same platform. Descriptive analysis and Cox regression models were produced. Results: Out of total 634 patients, 533 (84.1%) were HPVA and 101 (15.9%) were HPVI. 65% had SCC morphology (88.1%: HPVA; 11.9%: HPVI) and 35% had ECA differentiation (76.6%: HPVA; 23.4%: HPVI). Compared to ECA, patients with SCC were older (median age: 51 vs. 45 years old; p < 0.001), had higher HPVA status (88.1% vs. 76.6%; p < 0.001), and a higher rate of lymph-vascular invasion (LVI; 64.8% vs. 56.8%; p = 0.004). However, patients with ECA had a higher rate of metastases to pelvic organs (13.5% vs. 2.4%; p < 0.001). In univariable analysis, HPV status, tumor type, higher FIGO stage, older age, LVI positive, lymph node metastasis (LNM), and adjuvant treatment were all associated with impaired RFS and OS (all p <= 0.007). In multivariable analysis, LVI, HPV status, institution, and tumor type remained significant for RFS, while age at diagnosis, FIGO stage, LVI, and tumor type remained significant for OS. Conclusion: Tumor type and HPV status play significant role in determining survival outcomes in CC.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/227680
url https://hdl.handle.net/2445/227680
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.ygyno.2026.01.012
Gynecologic Oncology, 2026, vol. 205, p. 89-98
https://doi.org/10.1016/j.ygyno.2026.01.012
dc.rights.none.fl_str_mv http:// creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http:// creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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