Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule level

Soft matter encompasses multitude of systems like biomolecules, living cells, polymers, composites or blends. The increasing interest to better understand their physico-chemical properties has significantly favored the development of new techniques with unprecedented resolution. In this framework, a...

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Detalles Bibliográficos
Autor: Marcuello, Carlos
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/303813
Acceso en línea:http://hdl.handle.net/10261/303813
Access Level:acceso abierto
Palabra clave:Atomic force microscopy (AFM)
AFM nanoinfrared spectroscopy
Biomolecular interactions
Biophysics
Force spectroscopy
Nanoindentation
Nanoscale
Physico-chemical properties
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spelling Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule levelMarcuello, CarlosAtomic force microscopy (AFM)AFM nanoinfrared spectroscopyBiomolecular interactionsBiophysicsForce spectroscopyNanoindentationNanoscalePhysico-chemical propertiesSoft matter encompasses multitude of systems like biomolecules, living cells, polymers, composites or blends. The increasing interest to better understand their physico-chemical properties has significantly favored the development of new techniques with unprecedented resolution. In this framework, atomic force microscopy (AFM) can act as one main actor to address multitude of intrinsic sample characteristics at the nanoscale level. AFM presents many advantages in comparison to other bulk techniques as the assessment of individual entities discharging thus, ensemble averaging phenomena. Moreover, AFM enables the visualization of singular events that eventually can provide response of some open questions that still remain unclear. The present manuscript aims to make the reader aware of the potential applications in the employment of this tool by providing recent examples of scientific studies where AFM has been employed with success. Several operational modes like AFM imaging, AFM based force spectroscopy (AFM-FS), nanoindentation, AFM-nanoscale infrared spectroscopy (AFM-nanoIR) or magnetic force microscopy (MFM) will be fully explained to detail the type of information that AFM is capable to gather. Finally, future prospects will be delivered to discern the following steps to be conducted in this field.The author acknowledges the funding that covers his salary coming from EU Recovery action 2021 (CSIC - project code: QTP2103003).Peer reviewedAIMS PressEuropean CommissionConsejo Superior de Investigaciones Científicas (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/303813reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésAIMS Bioengineeringhttps://doi.org/10.3934/bioeng.2022020Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3038132026-05-22T06:33:51Z
dc.title.none.fl_str_mv Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule level
title Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule level
spellingShingle Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule level
Marcuello, Carlos
Atomic force microscopy (AFM)
AFM nanoinfrared spectroscopy
Biomolecular interactions
Biophysics
Force spectroscopy
Nanoindentation
Nanoscale
Physico-chemical properties
title_short Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule level
title_full Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule level
title_fullStr Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule level
title_full_unstemmed Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule level
title_sort Current and future perspectives of atomic force microscopy to elicit the intrinsic properties of soft matter at the single molecule level
dc.creator.none.fl_str_mv Marcuello, Carlos
author Marcuello, Carlos
author_facet Marcuello, Carlos
author_role author
dc.contributor.none.fl_str_mv European Commission
Consejo Superior de Investigaciones Científicas (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Atomic force microscopy (AFM)
AFM nanoinfrared spectroscopy
Biomolecular interactions
Biophysics
Force spectroscopy
Nanoindentation
Nanoscale
Physico-chemical properties
topic Atomic force microscopy (AFM)
AFM nanoinfrared spectroscopy
Biomolecular interactions
Biophysics
Force spectroscopy
Nanoindentation
Nanoscale
Physico-chemical properties
description Soft matter encompasses multitude of systems like biomolecules, living cells, polymers, composites or blends. The increasing interest to better understand their physico-chemical properties has significantly favored the development of new techniques with unprecedented resolution. In this framework, atomic force microscopy (AFM) can act as one main actor to address multitude of intrinsic sample characteristics at the nanoscale level. AFM presents many advantages in comparison to other bulk techniques as the assessment of individual entities discharging thus, ensemble averaging phenomena. Moreover, AFM enables the visualization of singular events that eventually can provide response of some open questions that still remain unclear. The present manuscript aims to make the reader aware of the potential applications in the employment of this tool by providing recent examples of scientific studies where AFM has been employed with success. Several operational modes like AFM imaging, AFM based force spectroscopy (AFM-FS), nanoindentation, AFM-nanoscale infrared spectroscopy (AFM-nanoIR) or magnetic force microscopy (MFM) will be fully explained to detail the type of information that AFM is capable to gather. Finally, future prospects will be delivered to discern the following steps to be conducted in this field.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/303813
url http://hdl.handle.net/10261/303813
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv AIMS Bioengineering
https://doi.org/10.3934/bioeng.2022020
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv AIMS Press
publisher.none.fl_str_mv AIMS Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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