Front microrheology of the non-Newtonian behavior of blood: scaling theory of erythrocyte aggregation by aging

We introduce a new framework to study the non-Newtonian behaviour of fluids at the microscale based on the analysis of front advancement. We apply this methodology to study the non-linear rheology of blood in microchannels. We carry out experiments in which the non-linear viscosity of blood samples...

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Autores: Trejo Soto, Claudia Andrea, Costa Miracle, E., Rodríguez-Villarreal, Ivón, Cid Vidal, Joan, Castro, Mario, Alarcón Cor, Tomás, Hernández Machado, Aurora
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/125552
Acceso en línea:https://hdl.handle.net/2445/125552
Access Level:acceso abierto
Palabra clave:Reologia (Biologia)
Plasma sanguini
Viscositat
Rheology (Biology)
Blood plasma
Viscosity
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spelling Front microrheology of the non-Newtonian behavior of blood: scaling theory of erythrocyte aggregation by agingTrejo Soto, Claudia AndreaCosta Miracle, E.Rodríguez-Villarreal, IvónCid Vidal, JoanCastro, MarioAlarcón Cor, TomásHernández Machado, AuroraReologia (Biologia)Plasma sanguiniViscositatRheology (Biology)Blood plasmaViscosityWe introduce a new framework to study the non-Newtonian behaviour of fluids at the microscale based on the analysis of front advancement. We apply this methodology to study the non-linear rheology of blood in microchannels. We carry out experiments in which the non-linear viscosity of blood samples is quantified at different haematocrits and ages. Under these conditions, blood exhibits a power-law dependence on the shear rate. In order to analyse our experimental data, we put forward a scaling theory which allows us to define an adhesion scaling number. This theory yields a scaling behaviour of the viscosity expressed as a function of the adhesion capillary number. By applying this scaling theory to samples of different ages, we are able to quantify how the characteristic adhesion energy varies as time progresses. This connection between microscopic and mesoscopic properties allows us to estimate quantitatively the change in the cell-cell adhesion energies as the sample agesRoyal Society of Chemistry2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/125552Articles publicats en revistes (Física de la Matèria Condensada)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1039/c6sm02412bSoft Matter, 2017, vol. 13, p. 3042-3047https://doi.org/10.1039/c6sm02412bcc-by (c) Trejo Soto, Claudia Andrea et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1255522026-05-27T06:46:51Z
dc.title.none.fl_str_mv Front microrheology of the non-Newtonian behavior of blood: scaling theory of erythrocyte aggregation by aging
title Front microrheology of the non-Newtonian behavior of blood: scaling theory of erythrocyte aggregation by aging
spellingShingle Front microrheology of the non-Newtonian behavior of blood: scaling theory of erythrocyte aggregation by aging
Trejo Soto, Claudia Andrea
Reologia (Biologia)
Plasma sanguini
Viscositat
Rheology (Biology)
Blood plasma
Viscosity
title_short Front microrheology of the non-Newtonian behavior of blood: scaling theory of erythrocyte aggregation by aging
title_full Front microrheology of the non-Newtonian behavior of blood: scaling theory of erythrocyte aggregation by aging
title_fullStr Front microrheology of the non-Newtonian behavior of blood: scaling theory of erythrocyte aggregation by aging
title_full_unstemmed Front microrheology of the non-Newtonian behavior of blood: scaling theory of erythrocyte aggregation by aging
title_sort Front microrheology of the non-Newtonian behavior of blood: scaling theory of erythrocyte aggregation by aging
dc.creator.none.fl_str_mv Trejo Soto, Claudia Andrea
Costa Miracle, E.
Rodríguez-Villarreal, Ivón
Cid Vidal, Joan
Castro, Mario
Alarcón Cor, Tomás
Hernández Machado, Aurora
author Trejo Soto, Claudia Andrea
author_facet Trejo Soto, Claudia Andrea
Costa Miracle, E.
Rodríguez-Villarreal, Ivón
Cid Vidal, Joan
Castro, Mario
Alarcón Cor, Tomás
Hernández Machado, Aurora
author_role author
author2 Costa Miracle, E.
Rodríguez-Villarreal, Ivón
Cid Vidal, Joan
Castro, Mario
Alarcón Cor, Tomás
Hernández Machado, Aurora
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Reologia (Biologia)
Plasma sanguini
Viscositat
Rheology (Biology)
Blood plasma
Viscosity
topic Reologia (Biologia)
Plasma sanguini
Viscositat
Rheology (Biology)
Blood plasma
Viscosity
description We introduce a new framework to study the non-Newtonian behaviour of fluids at the microscale based on the analysis of front advancement. We apply this methodology to study the non-linear rheology of blood in microchannels. We carry out experiments in which the non-linear viscosity of blood samples is quantified at different haematocrits and ages. Under these conditions, blood exhibits a power-law dependence on the shear rate. In order to analyse our experimental data, we put forward a scaling theory which allows us to define an adhesion scaling number. This theory yields a scaling behaviour of the viscosity expressed as a function of the adhesion capillary number. By applying this scaling theory to samples of different ages, we are able to quantify how the characteristic adhesion energy varies as time progresses. This connection between microscopic and mesoscopic properties allows us to estimate quantitatively the change in the cell-cell adhesion energies as the sample ages
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125552
url https://hdl.handle.net/2445/125552
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1039/c6sm02412b
Soft Matter, 2017, vol. 13, p. 3042-3047
https://doi.org/10.1039/c6sm02412b
dc.rights.none.fl_str_mv cc-by (c) Trejo Soto, Claudia Andrea et al., 2017
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Trejo Soto, Claudia Andrea et al., 2017
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv Articles publicats en revistes (Física de la Matèria Condensada)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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