Utilidad de la determinación periódica de la concentración intracelular de adenosina trifosfato (iATP) en los linfocitos T CD4⁺ estimulados con fitohemaglutinina para la predicción de complicaciones infecciosas en receptores de trasplante renal
Infectious complications remain a leading cause of morbidity and mortality after solid organ transplantation (SOT). They depend on the ‘net state of immunosuppression’ that emerges from a complex interaction between multiple factors, including the type of immunosuppresion regimen used, its timing an...
| Autor: | |
|---|---|
| Formato: | tesis doctoral |
| Fecha de publicación: | 2017 |
| País: | España |
| Recursos: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | español |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/22719 |
| Acesso em linha: | https://hdl.handle.net/20.500.14352/22719 |
| Access Level: | acceso abierto |
| Palavra-chave: | 616.61-089.843(043.2) Trasplante renal Inmunología Kidney transplant Immunology Cirugía Nefrología y urología 3213 Cirugía |
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Utilidad de la determinación periódica de la concentración intracelular de adenosina trifosfato (iATP) en los linfocitos T CD4⁺ estimulados con fitohemaglutinina para la predicción de complicaciones infecciosas en receptores de trasplante renalUsefulness of the measurement of intracellular adenosine-triphospate (iATP) produced by phytohemagglutinin-stimulated CD4⁺ T-lymphocytes to predict infection in kidney transplant recipientsPérez-Jacoiste Asín, María Asunción616.61-089.843(043.2)Trasplante renalInmunologíaKidney transplantImmunologyCirugíaNefrología y urología3213 CirugíaInfectious complications remain a leading cause of morbidity and mortality after solid organ transplantation (SOT). They depend on the ‘net state of immunosuppression’ that emerges from a complex interaction between multiple factors, including the type of immunosuppresion regimen used, its timing and dosage, the presence of underlying immune defects or viral infections, and the evolution of the graft function. Until now, clinicians who take care of SOT recipients have relied almost exclusively on the therapeutic drug monitoring of immunosuppressive drugs to explore the state of immunocompetence of their patients. However, this approach is limited because it does not take into account the influence of pharamcokinetic, pharmacodynamic and clinical variables. Currently, the optimal objective measurement of ‘net state of immunosupression’ is lacking. There is a need for the accurate quantification of this state to predict the development of infectious syndromes. The measurement of iATP levels in peripheral blood CD4+ T-lymphocytes following thir nonspecific stimulation with phytohemagglutinin (PHA), through the commercial assay Immuknow®, was approved by US Food and Drug Administration for detecting cell-mediated immunity in immunosuppressed patients...Universidad Complutense de MadridLópez Medrano, FranciscoSan Juan Garrido, RafaelAguado García, José MaríaUniversidad Complutense de Madrid20172017-10-0420172017-10-04doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/22719reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Españolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/227192026-06-02T12:44:21Z |
| dc.title.none.fl_str_mv |
Utilidad de la determinación periódica de la concentración intracelular de adenosina trifosfato (iATP) en los linfocitos T CD4⁺ estimulados con fitohemaglutinina para la predicción de complicaciones infecciosas en receptores de trasplante renal Usefulness of the measurement of intracellular adenosine-triphospate (iATP) produced by phytohemagglutinin-stimulated CD4⁺ T-lymphocytes to predict infection in kidney transplant recipients |
| title |
Utilidad de la determinación periódica de la concentración intracelular de adenosina trifosfato (iATP) en los linfocitos T CD4⁺ estimulados con fitohemaglutinina para la predicción de complicaciones infecciosas en receptores de trasplante renal |
| spellingShingle |
Utilidad de la determinación periódica de la concentración intracelular de adenosina trifosfato (iATP) en los linfocitos T CD4⁺ estimulados con fitohemaglutinina para la predicción de complicaciones infecciosas en receptores de trasplante renal Pérez-Jacoiste Asín, María Asunción 616.61-089.843(043.2) Trasplante renal Inmunología Kidney transplant Immunology Cirugía Nefrología y urología 3213 Cirugía |
| title_short |
Utilidad de la determinación periódica de la concentración intracelular de adenosina trifosfato (iATP) en los linfocitos T CD4⁺ estimulados con fitohemaglutinina para la predicción de complicaciones infecciosas en receptores de trasplante renal |
| title_full |
Utilidad de la determinación periódica de la concentración intracelular de adenosina trifosfato (iATP) en los linfocitos T CD4⁺ estimulados con fitohemaglutinina para la predicción de complicaciones infecciosas en receptores de trasplante renal |
| title_fullStr |
Utilidad de la determinación periódica de la concentración intracelular de adenosina trifosfato (iATP) en los linfocitos T CD4⁺ estimulados con fitohemaglutinina para la predicción de complicaciones infecciosas en receptores de trasplante renal |
| title_full_unstemmed |
Utilidad de la determinación periódica de la concentración intracelular de adenosina trifosfato (iATP) en los linfocitos T CD4⁺ estimulados con fitohemaglutinina para la predicción de complicaciones infecciosas en receptores de trasplante renal |
| title_sort |
Utilidad de la determinación periódica de la concentración intracelular de adenosina trifosfato (iATP) en los linfocitos T CD4⁺ estimulados con fitohemaglutinina para la predicción de complicaciones infecciosas en receptores de trasplante renal |
| dc.creator.none.fl_str_mv |
Pérez-Jacoiste Asín, María Asunción |
| author |
Pérez-Jacoiste Asín, María Asunción |
| author_facet |
Pérez-Jacoiste Asín, María Asunción |
| author_role |
author |
| dc.contributor.none.fl_str_mv |
López Medrano, Francisco San Juan Garrido, Rafael Aguado García, José María Universidad Complutense de Madrid |
| dc.subject.none.fl_str_mv |
616.61-089.843(043.2) Trasplante renal Inmunología Kidney transplant Immunology Cirugía Nefrología y urología 3213 Cirugía |
| topic |
616.61-089.843(043.2) Trasplante renal Inmunología Kidney transplant Immunology Cirugía Nefrología y urología 3213 Cirugía |
| description |
Infectious complications remain a leading cause of morbidity and mortality after solid organ transplantation (SOT). They depend on the ‘net state of immunosuppression’ that emerges from a complex interaction between multiple factors, including the type of immunosuppresion regimen used, its timing and dosage, the presence of underlying immune defects or viral infections, and the evolution of the graft function. Until now, clinicians who take care of SOT recipients have relied almost exclusively on the therapeutic drug monitoring of immunosuppressive drugs to explore the state of immunocompetence of their patients. However, this approach is limited because it does not take into account the influence of pharamcokinetic, pharmacodynamic and clinical variables. Currently, the optimal objective measurement of ‘net state of immunosupression’ is lacking. There is a need for the accurate quantification of this state to predict the development of infectious syndromes. The measurement of iATP levels in peripheral blood CD4+ T-lymphocytes following thir nonspecific stimulation with phytohemagglutinin (PHA), through the commercial assay Immuknow®, was approved by US Food and Drug Administration for detecting cell-mediated immunity in immunosuppressed patients... |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-10-04 2017 2017-10-04 |
| dc.type.none.fl_str_mv |
doctoral thesis http://purl.org/coar/resource_type/c_db06 |
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info:eu-repo/semantics/doctoralThesis |
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doctoralThesis |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.14352/22719 |
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https://hdl.handle.net/20.500.14352/22719 |
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Español spa |
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Español |
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spa |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad Complutense de Madrid |
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Universidad Complutense de Madrid |
| dc.source.none.fl_str_mv |
reponame:Docta Complutense instname:Universidad Complutense de Madrid (UCM) |
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Universidad Complutense de Madrid (UCM) |
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Docta Complutense |
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Docta Complutense |
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15,300719 |