Determination of ofloxacin in urine using UV/Vis absorption spectroelectrochemistry

UV–Vis absorption spectroelectrochemistry has been selected as a suitable multiresponse technique to determine the fluoroquinolone ofloxacin in urine samples without any previous pretreatment. Due to the modification of the working electrode surface during the oxidation of this antibiotic, the elect...

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Autores: Olmo Alonso, Fabiola, Colina Santamaría, Álvaro, Heras Vidaurre, Aránzazu
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Burgos (UBU)
Repositorio:Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:oai:riubu.ubu.es:10259/10195
Acceso en línea:http://hdl.handle.net/10259/10195
Access Level:acceso abierto
Palabra clave:Ofloxacin
Urine
Spectroelectrochemistry
Multivariate analysis
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
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spelling Determination of ofloxacin in urine using UV/Vis absorption spectroelectrochemistryOlmo Alonso, FabiolaColina Santamaría, ÁlvaroHeras Vidaurre, AránzazuOfloxacinUrineSpectroelectrochemistryMultivariate analysisQuímica analíticaElectroquímicaChemistry, AnalyticElectrochemistryUV–Vis absorption spectroelectrochemistry has been selected as a suitable multiresponse technique to determine the fluoroquinolone ofloxacin in urine samples without any previous pretreatment. Due to the modification of the working electrode surface during the oxidation of this antibiotic, the electrode has to be replaced or polished between measurements. A new spectroelectrochemistry cell has been developed, which allows in an simple way to perform reproducible experiments with different screen-printed electrodes. The new cell has been used to perform analysis in a complex matrix such as urine. Due to the trilinear character of the spectroelectrochemical data, PARAFAC has been used to determine ofloxacin with very good figures of merit, demonstrating the capability of trilinear methods to avoid the influence of some interfering compounds.Ministerio de Ciencia e Innovacion ´ and Agencia Estatal de Inves tigacion ´ (Grant numbers: MCIN/AEI/10.13039/501100011033, PID2020-113154RB-C21), Ministerio de Ciencia, Innovacion ´ y Uni versidades (Grant number: RED2022-134120-T), Junta de Castilla y Leon ´ and European Regional Development Fund (Grant number: BU036P23) are gratefully acknowledged for funding this work.Elsevier202520252024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10259/10195reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)instname:Universidad de Burgos (UBU)InglésMicrochemical Journal. 2024, V. 198, 110186https://doi.org/10.1016/j.microc.2024.110186info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2017-2020/PID2020-113154RB-C21info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/RED2022–134120-Tinfo:eu-repo/grantAgreement/Junta de Castilla y León//BU036P23Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riubu.ubu.es:10259/101952026-05-28T07:56:11Z
dc.title.none.fl_str_mv Determination of ofloxacin in urine using UV/Vis absorption spectroelectrochemistry
title Determination of ofloxacin in urine using UV/Vis absorption spectroelectrochemistry
spellingShingle Determination of ofloxacin in urine using UV/Vis absorption spectroelectrochemistry
Olmo Alonso, Fabiola
Ofloxacin
Urine
Spectroelectrochemistry
Multivariate analysis
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
title_short Determination of ofloxacin in urine using UV/Vis absorption spectroelectrochemistry
title_full Determination of ofloxacin in urine using UV/Vis absorption spectroelectrochemistry
title_fullStr Determination of ofloxacin in urine using UV/Vis absorption spectroelectrochemistry
title_full_unstemmed Determination of ofloxacin in urine using UV/Vis absorption spectroelectrochemistry
title_sort Determination of ofloxacin in urine using UV/Vis absorption spectroelectrochemistry
dc.creator.none.fl_str_mv Olmo Alonso, Fabiola
Colina Santamaría, Álvaro
Heras Vidaurre, Aránzazu
author Olmo Alonso, Fabiola
author_facet Olmo Alonso, Fabiola
Colina Santamaría, Álvaro
Heras Vidaurre, Aránzazu
author_role author
author2 Colina Santamaría, Álvaro
Heras Vidaurre, Aránzazu
author2_role author
author
dc.subject.none.fl_str_mv Ofloxacin
Urine
Spectroelectrochemistry
Multivariate analysis
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
topic Ofloxacin
Urine
Spectroelectrochemistry
Multivariate analysis
Química analítica
Electroquímica
Chemistry, Analytic
Electrochemistry
description UV–Vis absorption spectroelectrochemistry has been selected as a suitable multiresponse technique to determine the fluoroquinolone ofloxacin in urine samples without any previous pretreatment. Due to the modification of the working electrode surface during the oxidation of this antibiotic, the electrode has to be replaced or polished between measurements. A new spectroelectrochemistry cell has been developed, which allows in an simple way to perform reproducible experiments with different screen-printed electrodes. The new cell has been used to perform analysis in a complex matrix such as urine. Due to the trilinear character of the spectroelectrochemical data, PARAFAC has been used to determine ofloxacin with very good figures of merit, demonstrating the capability of trilinear methods to avoid the influence of some interfering compounds.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10259/10195
url http://hdl.handle.net/10259/10195
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Microchemical Journal. 2024, V. 198, 110186
https://doi.org/10.1016/j.microc.2024.110186
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2017-2020/PID2020-113154RB-C21
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica, Técnica y de Innovación 2021-2023/RED2022–134120-T
info:eu-repo/grantAgreement/Junta de Castilla y León//BU036P23
dc.rights.none.fl_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)
instname:Universidad de Burgos (UBU)
instname_str Universidad de Burgos (UBU)
reponame_str Repositorio Institucional de la Universidad de Burgos (RIUBU)
collection Repositorio Institucional de la Universidad de Burgos (RIUBU)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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