Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse

Introduction: Increased cardiovascular (CV) morbidity and mortality is observed in inflammatory joint diseases (IJDs) such as rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. However, the management of CV disease in these conditions is far from being well established.Areas cove...

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Autores: Cavagna, Lorenzo, Trallero-Araguás, Ernesto, Meloni, Federica, Cavazzana, Ilaria, Rojas-Serrano, Jorge, Feist, Eugen, Zanframundo, Giovanni, Morandi, Valentina, Meyer, Alain, Pereira da Silva, Jose Antonio, Matos Costa, Carlo Jorge, Molberg, Oyvind, Andersson, Helena, Codullo, Veronica, Mosca, Marta, Barsotti, Simone, Neri, Rossella, Cifrián Martínez, José Manuel|||0000-0003-5636-2740, López Mejías, Raquel, González-Gay Mantecón, Miguel Ángel|||0000-0002-7924-7406
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/18497
Acceso en línea:http://hdl.handle.net/10902/18497
Access Level:acceso abierto
Palabra clave:Antisynthetase Syndrome
Antisynthetase Antibodies
Arthritis
Myositis
Interstitial Lung Disease
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spelling Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourseCavagna, LorenzoTrallero-Araguás, ErnestoMeloni, FedericaCavazzana, IlariaRojas-Serrano, JorgeFeist, EugenZanframundo, GiovanniMorandi, ValentinaMeyer, AlainPereira da Silva, Jose AntonioMatos Costa, Carlo JorgeMolberg, OyvindAndersson, HelenaCodullo, VeronicaMosca, MartaBarsotti, SimoneNeri, RossellaCifrián Martínez, José Manuel|||0000-0003-5636-2740López Mejías, RaquelGonzález-Gay Mantecón, Miguel Ángel|||0000-0002-7924-7406Antisynthetase SyndromeAntisynthetase AntibodiesArthritisMyositisInterstitial Lung DiseaseIntroduction: Increased cardiovascular (CV) morbidity and mortality is observed in inflammatory joint diseases (IJDs) such as rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. However, the management of CV disease in these conditions is far from being well established.Areas covered: This review summarizes the main epidemiologic, pathophysiological, and clinical risk factors of CV disease associated with IJDs. Less common aspects on early diagnosis and risk stratification of the CV disease in these conditions are also discussed. In Europe, the most commonly used risk algorithm in patients with IJDs is the modified SCORE index based on the revised recommendations proposed by the EULAR task force in 2017.Expert opinion: Early identification of IJD patients at high risk of CV disease is essential. It should include the use of complementary noninvasive imaging techniques. A multidisciplinary approach aimed to improve heart-healthy habits, including strict control of classic CV risk factors is crucial. Adequate management of the underlying IJD is also of main importance since the reduction of disease activity decreases the risk of CV events. Non-steroidal anti-inflammatory drugs may have a lesser harmful effect in IJD than in the general population, due to their anti-inflammatory effects along with other potential beneficial effects.This research was partially funded by FOREUM—Foundation for Research in RheumatologyMDPI AGUniversidad de Cantabria20192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/18497J Clin Med. 2019 Nov 18;8(11). pii: E2013reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/184972026-06-02T12:39:31Z
dc.title.none.fl_str_mv Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse
title Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse
spellingShingle Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse
Cavagna, Lorenzo
Antisynthetase Syndrome
Antisynthetase Antibodies
Arthritis
Myositis
Interstitial Lung Disease
title_short Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse
title_full Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse
title_fullStr Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse
title_full_unstemmed Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse
title_sort Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse
dc.creator.none.fl_str_mv Cavagna, Lorenzo
Trallero-Araguás, Ernesto
Meloni, Federica
Cavazzana, Ilaria
Rojas-Serrano, Jorge
Feist, Eugen
Zanframundo, Giovanni
Morandi, Valentina
Meyer, Alain
Pereira da Silva, Jose Antonio
Matos Costa, Carlo Jorge
Molberg, Oyvind
Andersson, Helena
Codullo, Veronica
Mosca, Marta
Barsotti, Simone
Neri, Rossella
Cifrián Martínez, José Manuel|||0000-0003-5636-2740
López Mejías, Raquel
González-Gay Mantecón, Miguel Ángel|||0000-0002-7924-7406
author Cavagna, Lorenzo
author_facet Cavagna, Lorenzo
Trallero-Araguás, Ernesto
Meloni, Federica
Cavazzana, Ilaria
Rojas-Serrano, Jorge
Feist, Eugen
Zanframundo, Giovanni
Morandi, Valentina
Meyer, Alain
Pereira da Silva, Jose Antonio
Matos Costa, Carlo Jorge
Molberg, Oyvind
Andersson, Helena
Codullo, Veronica
Mosca, Marta
Barsotti, Simone
Neri, Rossella
Cifrián Martínez, José Manuel|||0000-0003-5636-2740
López Mejías, Raquel
González-Gay Mantecón, Miguel Ángel|||0000-0002-7924-7406
author_role author
author2 Trallero-Araguás, Ernesto
Meloni, Federica
Cavazzana, Ilaria
Rojas-Serrano, Jorge
Feist, Eugen
Zanframundo, Giovanni
Morandi, Valentina
Meyer, Alain
Pereira da Silva, Jose Antonio
Matos Costa, Carlo Jorge
Molberg, Oyvind
Andersson, Helena
Codullo, Veronica
Mosca, Marta
Barsotti, Simone
Neri, Rossella
Cifrián Martínez, José Manuel|||0000-0003-5636-2740
López Mejías, Raquel
González-Gay Mantecón, Miguel Ángel|||0000-0002-7924-7406
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Antisynthetase Syndrome
Antisynthetase Antibodies
Arthritis
Myositis
Interstitial Lung Disease
topic Antisynthetase Syndrome
Antisynthetase Antibodies
Arthritis
Myositis
Interstitial Lung Disease
description Introduction: Increased cardiovascular (CV) morbidity and mortality is observed in inflammatory joint diseases (IJDs) such as rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. However, the management of CV disease in these conditions is far from being well established.Areas covered: This review summarizes the main epidemiologic, pathophysiological, and clinical risk factors of CV disease associated with IJDs. Less common aspects on early diagnosis and risk stratification of the CV disease in these conditions are also discussed. In Europe, the most commonly used risk algorithm in patients with IJDs is the modified SCORE index based on the revised recommendations proposed by the EULAR task force in 2017.Expert opinion: Early identification of IJD patients at high risk of CV disease is essential. It should include the use of complementary noninvasive imaging techniques. A multidisciplinary approach aimed to improve heart-healthy habits, including strict control of classic CV risk factors is crucial. Adequate management of the underlying IJD is also of main importance since the reduction of disease activity decreases the risk of CV events. Non-steroidal anti-inflammatory drugs may have a lesser harmful effect in IJD than in the general population, due to their anti-inflammatory effects along with other potential beneficial effects.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/18497
url http://hdl.handle.net/10902/18497
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv J Clin Med. 2019 Nov 18;8(11). pii: E2013
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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