Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.

Ramírez, Julio; Ruiz-Esquide Torino, Virginia; Pomés, Isaac; Celis, Raquel; Cuervo, Andrea; Hernández Miguel, María Victoria; Pomés Talló, Jaume; Pablos, José L.; Sanmartí Sala, Raimon; Cañete Crespillo, Juan D.

Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.

INTRODUCTION: The aim of this study was to identify and characterize subclinical synovitis in patients with rheumatoid arthritis (RA) in clinical remission using power Doppler ultrasound (PDUS) and serum levels of biomarkers of inflammation and/or angiogenesis. METHODS: We selected patients with RA...

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Autores:	Ramírez, Julio, Ruiz-Esquide Torino, Virginia, Pomés, Isaac, Celis, Raquel, Cuervo, Andrea, Hernández Miguel, María Victoria, Pomés Talló, Jaume, Pablos, José L., Sanmartí Sala, Raimon, Cañete Crespillo, Juan D.
Tipo de documento:	artigo
Estado:	Versão publicada
Data de publicação:	2014
País:	España
Recursos:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/120172
Acesso em linha:	https://hdl.handle.net/2445/120172
Access Level:	Acceso aberto
Palavra-chave:	Artritis reumatoide Malalties de les articulacions Marcadors bioquímics Assaigs clínics Rheumatoid arthritis Joints diseases Biochemical markers Clinical trials

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spelling	Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.Ramírez, JulioRuiz-Esquide Torino, VirginiaPomés, IsaacCelis, RaquelCuervo, AndreaHernández Miguel, María VictoriaPomés Talló, JaumePablos, José L.Sanmartí Sala, RaimonCañete Crespillo, Juan D.Artritis reumatoideMalalties de les articulacionsMarcadors bioquímicsAssaigs clínicsRheumatoid arthritisJoints diseasesBiochemical markersClinical trialsINTRODUCTION: The aim of this study was to identify and characterize subclinical synovitis in patients with rheumatoid arthritis (RA) in clinical remission using power Doppler ultrasound (PDUS) and serum levels of biomarkers of inflammation and/or angiogenesis. METHODS: We selected patients with RA in clinical remission defined as a Disease activity score of 28 joints (DAS28)-erythrocyte sedimentation rate (ESR) <2.6 for more than six months tested by two independent rheumatologists. Clinical, epidemiological, demographic and serological data were analyzed. PDUS of knees and hands was performed by a sonographer. Synovial hypertrophy (SH) and PDUS signal were scored (grades 0 to 3). SH ≥2 and a PDUS signal was classified as active synovitis. Serum levels of biomarkers of inflammation/angiogenesis were determined by Quantibody Human Array. RESULTS: This study included 55 patients, of whom 25 (45.4%) met criteria for ultrasound-defined active synovitis. Patients with active synovitis had higher DAS28-C reactive protein (P = 0.023), DAS28-ESR (P = 0.06), simplified disease activity score, SDAI (P = 0.064), and only 12% were taking oral glucocorticoids (≤5 mg/day) compared with 40% of patients without active synovitis (P = 0.044). Patients with synovitis also had significantly higher serum levels of the angiogenic biomarkers angiopoietin-2 (P = 0.038), vascular endothelial growth factor-D (P = 0.018), placental growth factor (P = 0.043), stromal cell-derived factor-1 (P = 0.035), matrix metallopeptidase-2 (P = 0.027) and basic fibroblast growth factor (bFGF) (P = 0.007), but not of pro-inflammatory cytokines. CONCLUSIONS: Nearly half of the patients with RA in clinical remission had ultrasound-defined active synovitis, higher disease activity and less frequent oral glucocorticoid consumption than patients without active synovitis. This clinical situation was associated with a specific biological profile characterized by an excess of angiogenic mediators rather than persistent proinflammatory cytokine responses.BioMed Central2018201820142018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/120172Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/ar4431Arthritis Research & Therapy, 2014, vol. 16, num. 1, p. R5https://doi.org/10.1186/ar4431cc-by (c) Ramírez, Julio et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1201722026-05-29T05:05:01Z
dc.title.none.fl_str_mv	Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.
title	Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.
spellingShingle	Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers. Ramírez, Julio Artritis reumatoide Malalties de les articulacions Marcadors bioquímics Assaigs clínics Rheumatoid arthritis Joints diseases Biochemical markers Clinical trials
title_short	Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.
title_full	Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.
title_fullStr	Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.
title_full_unstemmed	Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.
title_sort	Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.
dc.creator.none.fl_str_mv	Ramírez, Julio Ruiz-Esquide Torino, Virginia Pomés, Isaac Celis, Raquel Cuervo, Andrea Hernández Miguel, María Victoria Pomés Talló, Jaume Pablos, José L. Sanmartí Sala, Raimon Cañete Crespillo, Juan D.
author	Ramírez, Julio
author_facet	Ramírez, Julio Ruiz-Esquide Torino, Virginia Pomés, Isaac Celis, Raquel Cuervo, Andrea Hernández Miguel, María Victoria Pomés Talló, Jaume Pablos, José L. Sanmartí Sala, Raimon Cañete Crespillo, Juan D.
author_role	author
author2	Ruiz-Esquide Torino, Virginia Pomés, Isaac Celis, Raquel Cuervo, Andrea Hernández Miguel, María Victoria Pomés Talló, Jaume Pablos, José L. Sanmartí Sala, Raimon Cañete Crespillo, Juan D.
author2_role	author author author author author author author author author
dc.subject.none.fl_str_mv	Artritis reumatoide Malalties de les articulacions Marcadors bioquímics Assaigs clínics Rheumatoid arthritis Joints diseases Biochemical markers Clinical trials
topic	Artritis reumatoide Malalties de les articulacions Marcadors bioquímics Assaigs clínics Rheumatoid arthritis Joints diseases Biochemical markers Clinical trials
description	INTRODUCTION: The aim of this study was to identify and characterize subclinical synovitis in patients with rheumatoid arthritis (RA) in clinical remission using power Doppler ultrasound (PDUS) and serum levels of biomarkers of inflammation and/or angiogenesis. METHODS: We selected patients with RA in clinical remission defined as a Disease activity score of 28 joints (DAS28)-erythrocyte sedimentation rate (ESR) <2.6 for more than six months tested by two independent rheumatologists. Clinical, epidemiological, demographic and serological data were analyzed. PDUS of knees and hands was performed by a sonographer. Synovial hypertrophy (SH) and PDUS signal were scored (grades 0 to 3). SH ≥2 and a PDUS signal was classified as active synovitis. Serum levels of biomarkers of inflammation/angiogenesis were determined by Quantibody Human Array. RESULTS: This study included 55 patients, of whom 25 (45.4%) met criteria for ultrasound-defined active synovitis. Patients with active synovitis had higher DAS28-C reactive protein (P = 0.023), DAS28-ESR (P = 0.06), simplified disease activity score, SDAI (P = 0.064), and only 12% were taking oral glucocorticoids (≤5 mg/day) compared with 40% of patients without active synovitis (P = 0.044). Patients with synovitis also had significantly higher serum levels of the angiogenic biomarkers angiopoietin-2 (P = 0.038), vascular endothelial growth factor-D (P = 0.018), placental growth factor (P = 0.043), stromal cell-derived factor-1 (P = 0.035), matrix metallopeptidase-2 (P = 0.027) and basic fibroblast growth factor (bFGF) (P = 0.007), but not of pro-inflammatory cytokines. CONCLUSIONS: Nearly half of the patients with RA in clinical remission had ultrasound-defined active synovitis, higher disease activity and less frequent oral glucocorticoid consumption than patients without active synovitis. This clinical situation was associated with a specific biological profile characterized by an excess of angiogenic mediators rather than persistent proinflammatory cytokine responses.
publishDate	2014
dc.date.none.fl_str_mv	2014 2018 2018 2018
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/120172
url	https://hdl.handle.net/2445/120172
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1186/ar4431 Arthritis Research & Therapy, 2014, vol. 16, num. 1, p. R5 https://doi.org/10.1186/ar4431
dc.rights.none.fl_str_mv	cc-by (c) Ramírez, Julio et al., 2014 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Ramírez, Julio et al., 2014 http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	10 p. application/pdf application/pdf
dc.publisher.none.fl_str_mv	BioMed Central
publisher.none.fl_str_mv	BioMed Central
dc.source.none.fl_str_mv	Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Patients with rheumatoid arthritis in clinical remission and ultrasound-defined active synovitis exhibit higher disease activity and increased serum levels of angiogenic biomarkers.

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