Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain

Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the in...

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Autores: Rubín-García M, Vitelli-Storelli F, Molina AJ, Zamora-Ros R, Aragonés N, Adarnaz E, Castaño-Vinyals G, Obón-Santacana M, Gómez-Acebo I, Molina-Barceló A, Fernández-Tardón G, Jiménez-Moleón JJ, Alguacil J, Chirlaque MD, Toledo E, Pérez-Gómez B, Pollán M, Kogevinas M, Martín V
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p8157
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/8157
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094823108&doi=10.3390%2fnu12113281&partnerID=40&md5=592310bbb10de453d3c3cd027793306a
Access Level:acceso abierto
Palabra clave:diet
epidemiology
gastric cancer
polyphenols
phenolic acids
stilbenes
lignans
anatomic
histologic
MCC-Spain
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spelling Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-SpainRubín-García MVitelli-Storelli FMolina AJZamora-Ros RAragonés NAdarnaz ECastaño-Vinyals GObón-Santacana MGómez-Acebo IMolina-Barceló AFernández-Tardón GJiménez-Moleón JJAlguacil JChirlaque MDToledo EPérez-Gómez BPollán MKogevinas MMartín Vdietepidemiologygastric cancerpolyphenolsphenolic acidsstilbeneslignansanatomichistologicMCC-SpainSeveral anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/8157https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094823108&doi=10.3390%2fnu12113281&partnerID=40&md5=592310bbb10de453d3c3cd027793306aNutrientsISSN: 20726643reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p81572026-06-11T12:45:17Z
dc.title.none.fl_str_mv Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
title Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
spellingShingle Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
Rubín-García M
diet
epidemiology
gastric cancer
polyphenols
phenolic acids
stilbenes
lignans
anatomic
histologic
MCC-Spain
title_short Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
title_full Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
title_fullStr Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
title_full_unstemmed Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
title_sort Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
dc.creator.none.fl_str_mv Rubín-García M
Vitelli-Storelli F
Molina AJ
Zamora-Ros R
Aragonés N
Adarnaz E
Castaño-Vinyals G
Obón-Santacana M
Gómez-Acebo I
Molina-Barceló A
Fernández-Tardón G
Jiménez-Moleón JJ
Alguacil J
Chirlaque MD
Toledo E
Pérez-Gómez B
Pollán M
Kogevinas M
Martín V
author Rubín-García M
author_facet Rubín-García M
Vitelli-Storelli F
Molina AJ
Zamora-Ros R
Aragonés N
Adarnaz E
Castaño-Vinyals G
Obón-Santacana M
Gómez-Acebo I
Molina-Barceló A
Fernández-Tardón G
Jiménez-Moleón JJ
Alguacil J
Chirlaque MD
Toledo E
Pérez-Gómez B
Pollán M
Kogevinas M
Martín V
author_role author
author2 Vitelli-Storelli F
Molina AJ
Zamora-Ros R
Aragonés N
Adarnaz E
Castaño-Vinyals G
Obón-Santacana M
Gómez-Acebo I
Molina-Barceló A
Fernández-Tardón G
Jiménez-Moleón JJ
Alguacil J
Chirlaque MD
Toledo E
Pérez-Gómez B
Pollán M
Kogevinas M
Martín V
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv diet
epidemiology
gastric cancer
polyphenols
phenolic acids
stilbenes
lignans
anatomic
histologic
MCC-Spain
topic diet
epidemiology
gastric cancer
polyphenols
phenolic acids
stilbenes
lignans
anatomic
histologic
MCC-Spain
description Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/8157
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094823108&doi=10.3390%2fnu12113281&partnerID=40&md5=592310bbb10de453d3c3cd027793306a
url https://fisabio.portalinvestigacion.com/publicaciones/8157
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094823108&doi=10.3390%2fnu12113281&partnerID=40&md5=592310bbb10de453d3c3cd027793306a
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Nutrients
ISSN: 20726643
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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