Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia

Aims There is lack of agreement on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging processing for guiding ventricular tachycardia (VT) ablation. We aim at developing and validating a systematic processing approach on LGE-CMR images to identify VT corridors that contain criti...

Descripción completa

Detalles Bibliográficos
Autores: Ramos Prada, Alba, Redondo Rodríguez, Andrés, Roca Luque, Ivo, Porta Sánchez, Andreu, ter Bekke, Rachel M.A., Quintanilla, Jorge G., Sánchez González, Javier, Peinado Peinado, Rafael, Merino, José Luis, Cluitmans, Matthijs, Holtackers, Robert J., Marina-Breysse, Manuel, Galán Arriola, Carlos, Enríquez Vázquez, Daniel, Vázquez Calvo, Sara, Alfonso Almazán, José Manuel, Pizarro, Gonzalo, Ibáñez, Borja, González-Ferrer, Juan José, Salgado-Aranda, Ricardo, Cañadas Godoy, Victoria, Calvo, David, Pérez-Villacastín, Julián, Pérez Castellano, Nicasio, Filgueiras Rama, David
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/755380
Acceso en línea:https://hdl.handle.net/10486/755380
https://dx.doi.org/10.1093/europace/euae244
Access Level:acceso abierto
Palabra clave:Ventricular tachycardia
Radiofrequency ablation
Magnetic resonance imaging
Imaging processing
Medicina
Descripción
Sumario:Aims There is lack of agreement on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging processing for guiding ventricular tachycardia (VT) ablation. We aim at developing and validating a systematic processing approach on LGE-CMR images to identify VT corridors that contain critical VT isthmus sites. Methods and results This is a translational study including 18 pigs with established myocardial infarction and inducible VT undergoing in vivo characterization of the anatomical and functional myocardial substrate associated with VT maintenance. Clinical validation was conducted in a multicentre series of 33 patients with ischaemic cardiomyopathy undergoing VT ablation. Three-dimensional LGE-CMR images were processed using systematic scanning of 15 signal intensity (SI) cut-off ranges to obtain surface visualization of all potential VT corridors. Analysis and comparisons of imaging and electrophysiological data were performed in individuals with full electrophysiological characterization of the isthmus sites of at least one VT morphology. In both the experimental pig model and patients undergoing VT ablation, all the electrophysiologically defined isthmus sites (n = 11 and n = 19, respectively) showed overlapping regions with CMR-based potential VT corridors. Such imaging-based VT corridors were less specific than electrophysiologically guided ablation lesions at critical isthmus sites. However, an optimized strategy using the 7 most relevant SI cut-off ranges among patients showed an increase in specificity compared to using 15 SI cut-off ranges (70 vs. 62%, respectively), without diminishing the capability to detect VT isthmus sites (sensitivity 100%). Conclusion Systematic imaging processing of LGE-CMR sequences using several SI cut-off ranges may improve and standardize procedure planning to identify VT isthmus sites

Similares en LA Referencia