FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted

Understanding the molecular mechanisms involved in cholangiocarcinoma (bile duct cancer) development and progression stands as a critical step for the development of novel therapies. Through an inter-species approach, this study provides evidence of the clinical and functional role of the transcript...

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Autores: Vallejo-Blanco, A. (Adrián)|||/items/142b3a3f-228d-4f91-b3cc-4147f8da10bf, Erice, O. (Oihane)|||/items/2541f3e8-8d0c-4c86-89d1-c245e534633e, Entrialgo-Cadierno, R. (Rodrigo)|||/items/0ac6fab0-1703-4571-929b-363e142032ac, Feliu-Gascon, I. (Iker)|||/items/bdd96323-aa06-4190-8895-563f1a4eea0d, Guruceaga-Martínez, E. (Elizabeth)|||/items/71d8df8b-4fab-4004-a38e-4057dddc85b2, Perugorria, M.J. (María J.)|||/items/bc5acab9-2480-4b1a-a8b7-72354639c5d9, Olaizola, P. (Paula)|||/items/5426b4b4-4ac7-46f7-8304-17cb549c08a4, Muggli, A. (Alexandra)|||/items/9cb7afe5-37f7-4f69-858b-df0b92b124ba, Macaya-Erro, I. (Irati)|||/items/3460ebe5-8f9a-4667-9f97-b1d1654bbb60, O’Dell, M. (Michael)|||/items/a9af39ab-9234-4a0f-a393-73acf0451f2a, Ruiz-Fernandez-de-Cordoba, B. (Borja)|||/items/d8fd5d77-c85e-4c43-b6df-2b85dffa2816, Ortiz-Espinosa, S. (Sergio)|||/items/366128c7-0213-4250-90c8-37cf8c008553, Hezel, A.F. (Aram F.)|||/items/24ca5192-dfeb-47b0-a754-a384b26b2b71, Arozarena, I. (Imanol)|||/items/8f5f8a81-fba8-4962-92dc-3eac25dadab3, Lecanda, F. (Fernando)|||/items/3fac5441-504d-4927-979a-5460140b12ec, Avila, M.A. (Matías Antonio)|||/items/3ad9abbb-c18d-445b-86cf-cb76be15419f, Evert, M. (Matthias)|||/items/d118ff36-a7cd-4ac8-95d4-9dc51a1e898b, Ponz-Sarvise, M. (Mariano)|||/items/2439c580-068e-431b-a20d-bdeab1b7c3ad, Calvisi, D.F. (Diego F.)|||/items/f1fd12a7-edff-43c9-a8a8-425bd3a0d865, Banales, J.M. (Jesús M.)|||/items/0c1309ae-e4e4-4e85-b2f1-567a388889d5, Vicent-Cambra, S. (Silvestre)|||/items/20c60fd9-edba-4dba-942c-3669eb079816, García-Fernández-de-Barrena, M. (Maite)|||/items/cfa77580-40b9-43a4-b237-b234ef7fb6cb
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/63351
Acceso en línea:https://hdl.handle.net/10171/63351
Access Level:acceso abierto
Palabra clave:FOSL1
Cholangiocarcinoma
Transcription factors
Genetics
Targeted therapies
Descripción
Sumario:Understanding the molecular mechanisms involved in cholangiocarcinoma (bile duct cancer) development and progression stands as a critical step for the development of novel therapies. Through an inter-species approach, this study provides evidence of the clinical and functional role of the transcription factor FOSL1 in cholangiocarcinoma. Moreover, we report that downstream effectors of FOSL1 are susceptible to pharmacological inhibition, thus providing new opportunities for therapeutic intervention.

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