Table_8_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx [Dataset]

Chronic lymphocytic leukemia (CLL) is a lymphoid neoplasm characterized by the accumulation of mature B cells. The diagnosis is established by the detection of monoclonal B lymphocytes in peripheral blood, even in early stages [monoclonal B-cell lymphocytosis (MBLhi)], and its clinical course is hig...

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Autores: Landeira-Viñuela, Alicia, Arias-Hidalgo, Carlota, Juanes-Velasco, Pablo, Alcoceba, Miguel, Navarro-Bailón, Almudena, Pedreira, C. E., Lécrevisse, Quentin, Díaz-Muñoz, Laura, Sánchez-Santos, José Manuel, Hernández, Ángela-Patricia, García-Vaquero, Marina L., Góngora, Rafael, De Las Rivas, Javier, González, Marcos, Orfao, Alberto, Fuentes, Manuel
Tipo de recurso: conjunto de datos
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/331195
Acceso en línea:http://hdl.handle.net/10261/331195
Access Level:acceso abierto
Palabra clave:Soluble immune checkpoints
Cytokines profiles
Cellular microenvironment
Chronic lymphocytic leukaemia (CLL)
Immune dysfunction
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spelling Table_8_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx [Dataset]Landeira-Viñuela, AliciaArias-Hidalgo, CarlotaJuanes-Velasco, PabloAlcoceba, MiguelNavarro-Bailón, AlmudenaPedreira, C. E.Lécrevisse, QuentinDíaz-Muñoz, LauraSánchez-Santos, José ManuelHernández, Ángela-PatriciaGarcía-Vaquero, Marina L.Góngora, RafaelDe Las Rivas, JavierGonzález, MarcosOrfao, AlbertoFuentes, ManuelSoluble immune checkpointsCytokines profilesCellular microenvironmentChronic lymphocytic leukaemia (CLL)Immune dysfunctionChronic lymphocytic leukemia (CLL) is a lymphoid neoplasm characterized by the accumulation of mature B cells. The diagnosis is established by the detection of monoclonal B lymphocytes in peripheral blood, even in early stages [monoclonal B-cell lymphocytosis (MBLhi)], and its clinical course is highly heterogeneous. In fact, there are well-characterized multiple prognostic factors that are also related to the observed genetic heterogenicity, such as immunoglobulin heavy chain variable region (IGHV) mutational status, del17p, and TP53 mutations, among others. Moreover, a dysregulation of the immune system (innate and adaptive immunity) has been observed in CLL patients, with strong impact on immune surveillance and consequently on the onset, evolution, and therapy response. In addition, the tumor microenvironment is highly complex and heterogeneous (i.e., matrix, fibroblast, endothelial cells, and immune cells), playing a critical role in the evolution of CLL. In this study, a quantitative profile of 103 proteins (cytokines, chemokines, growth/regulatory factors, immune checkpoints, and soluble receptors) in 67 serum samples (57 CLL and 10 MBLhi) has been systematically evaluated. Also, differential profiles of soluble immune factors that discriminate between MBLhi and CLL (sCD47, sCD27, sTIMD-4, sIL-2R, and sULBP-1), disease progression (sCD48, sCD27, sArginase-1, sLAG-3, IL-4, and sIL-2R), or among profiles correlated with other prognostic factors, such as IGHV mutational status (CXCL11/I-TAC, CXCL10/IP-10, sHEVM, and sLAG-3), were deciphered. These results pave the way to explore the role of soluble immune checkpoints as a promising source of biomarkers in CLL, to provide novel insights into the immune suppression process and/or dysfunction, mostly on T cells, in combination with cellular balance disruption and microenvironment polarization leading to tumor escape.Peer reviewedFigshareConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/vnd.ms-excelhttp://hdl.handle.net/10261/331195reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésLandeira-Viñuela, Alicia; Arias-Hidalgo, Carlota; Juanes-Velasco, Pablo; Alcoceba, Miguel; Navarro-Bailón, Almudena; Pedreira, C. E.; Lécrevisse, Quentin; Díaz-Muñoz, Laura; Sanchez-Santos, Jose Manuel; Hernández, Ángela-Patricia; García-Vaquero, Marina L.; Góngora, Rafael; De Las Rivas, Javier; González, Marcos; Orfao, Alberto; Fuentes, Manuel. Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction. http://dx.doi.org/10.3389/fimmu.2022.965905 . http://hdl.handle.net/10261/297222https://doi.org/10.3389/fimmu.2022.965905.s012Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3311952026-05-22T06:33:51Z
dc.title.none.fl_str_mv Table_8_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx [Dataset]
title Table_8_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx [Dataset]
spellingShingle Table_8_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx [Dataset]
Landeira-Viñuela, Alicia
Soluble immune checkpoints
Cytokines profiles
Cellular microenvironment
Chronic lymphocytic leukaemia (CLL)
Immune dysfunction
title_short Table_8_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx [Dataset]
title_full Table_8_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx [Dataset]
title_fullStr Table_8_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx [Dataset]
title_full_unstemmed Table_8_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx [Dataset]
title_sort Table_8_Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.xlsx [Dataset]
dc.creator.none.fl_str_mv Landeira-Viñuela, Alicia
Arias-Hidalgo, Carlota
Juanes-Velasco, Pablo
Alcoceba, Miguel
Navarro-Bailón, Almudena
Pedreira, C. E.
Lécrevisse, Quentin
Díaz-Muñoz, Laura
Sánchez-Santos, José Manuel
Hernández, Ángela-Patricia
García-Vaquero, Marina L.
Góngora, Rafael
De Las Rivas, Javier
González, Marcos
Orfao, Alberto
Fuentes, Manuel
author Landeira-Viñuela, Alicia
author_facet Landeira-Viñuela, Alicia
Arias-Hidalgo, Carlota
Juanes-Velasco, Pablo
Alcoceba, Miguel
Navarro-Bailón, Almudena
Pedreira, C. E.
Lécrevisse, Quentin
Díaz-Muñoz, Laura
Sánchez-Santos, José Manuel
Hernández, Ángela-Patricia
García-Vaquero, Marina L.
Góngora, Rafael
De Las Rivas, Javier
González, Marcos
Orfao, Alberto
Fuentes, Manuel
author_role author
author2 Arias-Hidalgo, Carlota
Juanes-Velasco, Pablo
Alcoceba, Miguel
Navarro-Bailón, Almudena
Pedreira, C. E.
Lécrevisse, Quentin
Díaz-Muñoz, Laura
Sánchez-Santos, José Manuel
Hernández, Ángela-Patricia
García-Vaquero, Marina L.
Góngora, Rafael
De Las Rivas, Javier
González, Marcos
Orfao, Alberto
Fuentes, Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Soluble immune checkpoints
Cytokines profiles
Cellular microenvironment
Chronic lymphocytic leukaemia (CLL)
Immune dysfunction
topic Soluble immune checkpoints
Cytokines profiles
Cellular microenvironment
Chronic lymphocytic leukaemia (CLL)
Immune dysfunction
description Chronic lymphocytic leukemia (CLL) is a lymphoid neoplasm characterized by the accumulation of mature B cells. The diagnosis is established by the detection of monoclonal B lymphocytes in peripheral blood, even in early stages [monoclonal B-cell lymphocytosis (MBLhi)], and its clinical course is highly heterogeneous. In fact, there are well-characterized multiple prognostic factors that are also related to the observed genetic heterogenicity, such as immunoglobulin heavy chain variable region (IGHV) mutational status, del17p, and TP53 mutations, among others. Moreover, a dysregulation of the immune system (innate and adaptive immunity) has been observed in CLL patients, with strong impact on immune surveillance and consequently on the onset, evolution, and therapy response. In addition, the tumor microenvironment is highly complex and heterogeneous (i.e., matrix, fibroblast, endothelial cells, and immune cells), playing a critical role in the evolution of CLL. In this study, a quantitative profile of 103 proteins (cytokines, chemokines, growth/regulatory factors, immune checkpoints, and soluble receptors) in 67 serum samples (57 CLL and 10 MBLhi) has been systematically evaluated. Also, differential profiles of soluble immune factors that discriminate between MBLhi and CLL (sCD47, sCD27, sTIMD-4, sIL-2R, and sULBP-1), disease progression (sCD48, sCD27, sArginase-1, sLAG-3, IL-4, and sIL-2R), or among profiles correlated with other prognostic factors, such as IGHV mutational status (CXCL11/I-TAC, CXCL10/IP-10, sHEVM, and sLAG-3), were deciphered. These results pave the way to explore the role of soluble immune checkpoints as a promising source of biomarkers in CLL, to provide novel insights into the immune suppression process and/or dysfunction, mostly on T cells, in combination with cellular balance disruption and microenvironment polarization leading to tumor escape.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
Publisher's version
info:eu-repo/semantics/publishedVersion
format dataset
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/331195
url http://hdl.handle.net/10261/331195
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Landeira-Viñuela, Alicia; Arias-Hidalgo, Carlota; Juanes-Velasco, Pablo; Alcoceba, Miguel; Navarro-Bailón, Almudena; Pedreira, C. E.; Lécrevisse, Quentin; Díaz-Muñoz, Laura; Sanchez-Santos, Jose Manuel; Hernández, Ángela-Patricia; García-Vaquero, Marina L.; Góngora, Rafael; De Las Rivas, Javier; González, Marcos; Orfao, Alberto; Fuentes, Manuel. Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction. http://dx.doi.org/10.3389/fimmu.2022.965905 . http://hdl.handle.net/10261/297222
https://doi.org/10.3389/fimmu.2022.965905.s012
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/vnd.ms-excel
dc.publisher.none.fl_str_mv Figshare
publisher.none.fl_str_mv Figshare
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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