Profiling of genetically modified organisms using omics technologies

Strict regulations including risk assessment, labeling, traceability, and marketing have been established due to the controversial safety aspects of genetically modified organisms (GMOs). One of the main polemic issues associated with GMO safety are the possible unintended effects, defined as effect...

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Detalles Bibliográficos
Autores: Valdés, Alberto, Simó, Carolina, Ibáñez, Clara, García-Cañas, Virginia
Tipo de recurso: otro
Estado:Versión aceptada para publicación
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/100248
Acceso en línea:http://hdl.handle.net/10261/100248
Access Level:acceso abierto
Palabra clave:Substantial equivalence
Transcriptomics
Proteomics
Metabolomics
Omics
Unintended effects
Transgenic crops
Gene expression profiling
GMO
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spelling Profiling of genetically modified organisms using omics technologiesValdés, AlbertoSimó, CarolinaIbáñez, ClaraGarcía-Cañas, VirginiaSubstantial equivalenceTranscriptomicsProteomicsMetabolomicsOmicsUnintended effectsTransgenic cropsGene expression profilingGMOStrict regulations including risk assessment, labeling, traceability, and marketing have been established due to the controversial safety aspects of genetically modified organisms (GMOs). One of the main polemic issues associated with GMO safety are the possible unintended effects, defined as effects that go beyond the primary expected effects of the genetic modification. In order to effectively investigate the potential adverse effects on the human health, including the existence or not of unintended effects, new analytical tools are needed to facilitate comprehensive compositional studies of GMOs. In this context, profiling technologies have the potential to provide valuable information regarding GMO composition that can be useful for characterization, traceability, and even GMO detection. In this chapter, the application of the main -omics technologies (transcriptomics, proteomics, and metabolomics) in combination with bioinformatics and chemometrics tools to GMO profiling is discussed. © 2014 Elsevier B.V.This work was supported by AGL2011-29857-C03-01 project (Ministerio de Economía y Competitividad, Spain), and CSD2007-00063 FUN-C-FOOD (Programa CONSOLIDER, Ministerio de Educación y Ciencia, Spain). A.V. thanks the Ministerio de Economía y Competitividad for his FPI pre-doctoral fellowship.Peer ReviewedElsevierMinisterio de Economía y Competitividad (España)Ministerio de Educación y Ciencia (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2014201420142014info:eu-repo/semantics/otherhttp://purl.org/coar/resource_type/c_3248Postprintinfo:eu-repo/semantics/acceptedVersioninfo:eu-repo/semantics/bookParthttp://hdl.handle.net/10261/100248reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/B978-0-444-62650-9.00013-0Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1002482026-05-22T06:33:51Z
dc.title.none.fl_str_mv Profiling of genetically modified organisms using omics technologies
title Profiling of genetically modified organisms using omics technologies
spellingShingle Profiling of genetically modified organisms using omics technologies
Valdés, Alberto
Substantial equivalence
Transcriptomics
Proteomics
Metabolomics
Omics
Unintended effects
Transgenic crops
Gene expression profiling
GMO
title_short Profiling of genetically modified organisms using omics technologies
title_full Profiling of genetically modified organisms using omics technologies
title_fullStr Profiling of genetically modified organisms using omics technologies
title_full_unstemmed Profiling of genetically modified organisms using omics technologies
title_sort Profiling of genetically modified organisms using omics technologies
dc.creator.none.fl_str_mv Valdés, Alberto
Simó, Carolina
Ibáñez, Clara
García-Cañas, Virginia
author Valdés, Alberto
author_facet Valdés, Alberto
Simó, Carolina
Ibáñez, Clara
García-Cañas, Virginia
author_role author
author2 Simó, Carolina
Ibáñez, Clara
García-Cañas, Virginia
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministerio de Educación y Ciencia (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Substantial equivalence
Transcriptomics
Proteomics
Metabolomics
Omics
Unintended effects
Transgenic crops
Gene expression profiling
GMO
topic Substantial equivalence
Transcriptomics
Proteomics
Metabolomics
Omics
Unintended effects
Transgenic crops
Gene expression profiling
GMO
description Strict regulations including risk assessment, labeling, traceability, and marketing have been established due to the controversial safety aspects of genetically modified organisms (GMOs). One of the main polemic issues associated with GMO safety are the possible unintended effects, defined as effects that go beyond the primary expected effects of the genetic modification. In order to effectively investigate the potential adverse effects on the human health, including the existence or not of unintended effects, new analytical tools are needed to facilitate comprehensive compositional studies of GMOs. In this context, profiling technologies have the potential to provide valuable information regarding GMO composition that can be useful for characterization, traceability, and even GMO detection. In this chapter, the application of the main -omics technologies (transcriptomics, proteomics, and metabolomics) in combination with bioinformatics and chemometrics tools to GMO profiling is discussed. © 2014 Elsevier B.V.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/other
http://purl.org/coar/resource_type/c_3248
Postprint
info:eu-repo/semantics/acceptedVersion
dc.type.openaire.fl_str_mv info:eu-repo/semantics/bookPart
format other
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/100248
url http://hdl.handle.net/10261/100248
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/B978-0-444-62650-9.00013-0
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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