Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4

Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals. Methods:...

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Detalles Bibliográficos
Autores: Sánchez Benavides, Gonzalo, Salvadó, Gemma, Arenaza Urquijo, Eider M., Grau, Oriol (Grau Rivera), Suárez-Calvet, Marc, Milà Alomà, Marta, González de Echávarri, José Maria, Minguillón, Carolina, Crous-Bou, Marta, Niñerola-Baizán, Aida, Perissinotti, Andrés, Gispert, Juan Domingo, Molinuevo, José Luis, ALFA Study
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/47574
Acceso en línea:http://hdl.handle.net/10230/47574
http://dx.doi.org/10.1002/dad2.12127
Access Level:acceso abierto
Palabra clave:Alzheimer&apos
s disease
Amyloid
Informant reports
Preclinical
Subjective cognitive decline
Descripción
Sumario:Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals. Methods: A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status. Results: Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003). Discussion: Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.

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