Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence.

Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insight...

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Detalles Bibliográficos
Autores: Toda, Haruka, Díaz Varela, Míriam, Seguí Barber, Joan, Roobsoong, Wanlapa, Baro, Barbara, Garcia Silva, Susana, Galiano, Alicia, Gualdrón López, Melisa, Almeida, Anne Cristine Gomes, Brito, Marcelo A. M., Cardoso de Melo, Gisely, Aparici Herraiz, Iris, Castro Cavadía, Carlos, Monteiro, Wuelton Marcelo, Borràs, Eva, Sabidó Aguadé, Eduard, Almeida, Igor Correia de, Chojnacki, Jakub, Martínez Picado, Francisco Javier, Calvo, Maria, Armengol, Maria del Pilar, Carmona Fonseca, Jaime, Yasnot, María Fernanda, Lauzurica, Ricardo, Marcilla, Antonio, Peinado, Hector, Galinski, Mary R., Lacerda, Marcus V. G., Sattabongkot, Jetsumon, Fernández Becerra, Carmen, Portillo Obando, Hernando A. del
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/182976
Acceso en línea:https://hdl.handle.net/2445/182976
Access Level:acceso abierto
Palabra clave:Malària
Relacions hoste-paràsit
Malaria
Host-parasite relationships
Descripción
Sumario:Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen.

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